SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qo1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		3 / 3 ALA A  50
THR A  69
PHE A  38
 None
 0.70A 2c6nB-4qo1A:
undetectable		 2c6nB-4qo1A:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		6 / 12 ALA A  25
MET A  35
ARG A  73
ASN A  78
VAL A  80
ALA A  99
 None
 0.73A 3qxtA-4qo1A:
20.8		 3qxtA-4qo1A:
63.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		7 / 12 LEU A   5
ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
 None
 0.50A 3qxtB-4qo1A:
21.2		 3qxtB-4qo1A:
63.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		7 / 12 ALA A  25
MET A  35
ARG A  73
ASN A  75
VAL A  80
ALA A  99
TYR A 113
 None
 0.62A 3qxvA-4qo1A:
21.1		 3qxvA-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		6 / 12 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
 None
 0.62A 3qxvB-4qo1A:
21.3		 3qxvB-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		6 / 11 ALA A  25
MET A  35
ARG A  73
ASN A  75
VAL A  80
ALA A  99
 None
 0.58A 3qxvC-4qo1A:
21.5		 3qxvC-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		6 / 12 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
 None
 0.57A 3qxvD-4qo1A:
21.2		 3qxvD-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		6 / 12 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
 None
 0.62A 3qxvE-4qo1A:
18.1		 3qxvE-4qo1A:
62.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53
(Lama
glama) 		5 / 11 PRO A 101
ALA A  98
TRP A  54
ASN A  53
VAL A  80
 None
 1.22A 5c8tB-4qo1A:
undetectable		 5c8tB-4qo1A:
13.96