SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 8 LEU A 113
PRO A  76
VAL A 103
MET A  71
 None
HEC  A 603 (-3.7A)
None
HEC  A 603 ( 2.4A)
 1.21A 2qd2A-4qo5A:
undetectable		 2qd2A-4qo5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 8 TRP A 278
PHE A 275
GLU A 280
SER A 281
 HEC  A 607 (-4.7A)
None
None
None
 1.32A 3rqlA-4qo5A:
2.6
3rqlB-4qo5A:
undetectable		 3rqlA-4qo5A:
21.94
3rqlB-4qo5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 8 SER A 281
TRP A 278
PHE A 275
GLU A 280
 None
HEC  A 607 (-4.7A)
None
None
 1.26A 4cx7A-4qo5A:
undetectable
4cx7B-4qo5A:
undetectable		 4cx7A-4qo5A:
20.26
4cx7B-4qo5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		3 / 3 VAL A  44
SER A  45
THR A  48
 None
 0.33A 4luhA-4qo5A:
4.4		 4luhA-4qo5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		5 / 10 LEU A 391
LEU A 397
ILE A 166
THR A 465
VAL A 480
 None
 1.20A 4mk4A-4qo5A:
undetectable		 4mk4A-4qo5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		5 / 11 GLY A 225
GLY A 230
PRO A 135
THR A 134
ILE A 132
 None
HEC  A 606 ( 3.9A)
HEC  A 605 ( 4.8A)
None
HEC  A 602 ( 4.6A)
 0.99A 4njvB-4qo5A:
undetectable		 4njvB-4qo5A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		5 / 11 GLY A 225
GLY A 230
PRO A 135
THR A 134
ILE A 132
 None
HEC  A 606 ( 3.9A)
HEC  A 605 ( 4.8A)
None
HEC  A 602 ( 4.6A)
 0.94A 4njvC-4qo5A:
undetectable		 4njvC-4qo5A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		5 / 12 VAL A 221
PRO A 131
HIS A 250
THR A  48
GLY A 106
 HEC  A 601 (-3.9A)
HEC  A 601 ( 4.1A)
HEC  A 602 (-3.3A)
None
HEC  A 602 (-4.2A)
 1.49A 4olfA-4qo5A:
undetectable		 4olfA-4qo5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 7 VAL A 321
TRP A 301
LEU A 319
SER A 318
 None
None
HEC  A 605 (-4.8A)
HEC  A 605 (-2.7A)
 1.02A 4zphA-4qo5A:
0.9
4zphB-4qo5A:
undetectable		 4zphA-4qo5A:
20.31
4zphB-4qo5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 6 ASP A  65
HIS A 250
ARG A 249
ILE A  62
 None
HEC  A 602 (-3.3A)
HEC  A 602 ( 3.9A)
HEC  A 602 (-4.1A)
 1.17A 5a06A-4qo5A:
undetectable		 5a06A-4qo5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 5 ASP A  65
HIS A 250
ARG A 249
ILE A  62
 None
HEC  A 602 (-3.3A)
HEC  A 602 ( 3.9A)
HEC  A 602 (-4.1A)
 1.19A 5a06B-4qo5A:
undetectable		 5a06B-4qo5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 5 ASP A  65
HIS A 250
ARG A 249
ILE A  62
 None
HEC  A 602 (-3.3A)
HEC  A 602 ( 3.9A)
HEC  A 602 (-4.1A)
 1.19A 5a06D-4qo5A:
undetectable		 5a06D-4qo5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 5 ASP A  65
HIS A 250
ARG A 249
ILE A  62
 None
HEC  A 602 (-3.3A)
HEC  A 602 ( 3.9A)
HEC  A 602 (-4.1A)
 1.17A 5a06F-4qo5A:
undetectable		 5a06F-4qo5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 8 TYR A 149
GLY A 241
ALA A 197
GLY A 200
 HEC  A 605 (-4.1A)
None
None
None
 0.85A 5albL-4qo5A:
undetectable		 5albL-4qo5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 6 THR A 244
ALA A 245
TYR A 149
HIS A 229
 HEC  A 602 ( 2.7A)
HEC  A 606 (-3.8A)
HEC  A 605 (-4.1A)
HEC  A 602 (-4.3A)
 0.88A 5ecoA-4qo5A:
undetectable		 5ecoA-4qo5A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qo5 HYPOTHETICAL
MULTIHEME PROTEIN
(Ignicoccus
hospitalis) 		4 / 8 SER A 281
TRP A 278
PHE A 275
GLU A 280
 None
HEC  A 607 (-4.7A)
None
None
 1.31A 5uo7A-4qo5A:
undetectable
5uo7B-4qo5A:
undetectable		 5uo7A-4qo5A:
21.57
5uo7B-4qo5A:
21.57