SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 VAL A 215
VAL A 217
TRP A 170
 None
 0.68A 1bdwA-4qp0A:
undetectable
1bdwB-4qp0A:
undetectable		 1bdwA-4qp0A:
5.02
1bdwB-4qp0A:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		4 / 6 PRO A 176
TRP A  55
GLU A 220
TRP A 111
 None
 1.29A 1ffyA-4qp0A:
1.3		 1ffyA-4qp0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 GLU A 293
ASN A  25
TRP A  55
 None
 1.23A 1r15C-4qp0A:
undetectable		 1r15C-4qp0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 GLU A 293
ASN A  25
TRP A  55
 None
 1.27A 1r15D-4qp0A:
undetectable		 1r15D-4qp0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 GLU A 293
ASN A  25
TRP A  55
 None
 1.24A 1r15E-4qp0A:
2.6		 1r15E-4qp0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 GLU A 293
ASN A  25
TRP A  55
 None
 1.23A 1r15F-4qp0A:
2.6		 1r15F-4qp0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 LEU A  29
THR A 166
ILE A  93
SER A  98
PHE A  41
 None
 1.47A 1xoqA-4qp0A:
undetectable		 1xoqA-4qp0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 LEU A  29
THR A 166
ILE A  93
SER A  98
PHE A  41
 None
 1.49A 1xoqB-4qp0A:
undetectable		 1xoqB-4qp0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		4 / 7 ASP A 242
PHE A 241
ARG A 225
ALA A 285
 None
 1.24A 2e5dA-4qp0A:
3.3
2e5dB-4qp0A:
3.2		 2e5dA-4qp0A:
21.36
2e5dB-4qp0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		6 / 12 ASN A 174
GLU A 175
HIS A 256
TYR A 258
GLU A 293
TRP A 324
 None
 0.82A 2v3dA-4qp0A:
7.6		 2v3dA-4qp0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 10 ILE A  93
ILE A  89
GLY A  85
VAL A  37
LEU A 156
 None
 1.32A 3elzB-4qp0A:
undetectable		 3elzB-4qp0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 10 ILE A  93
ILE A  89
GLY A  85
VAL A  37
LEU A 156
 None
 1.10A 3em0A-4qp0A:
undetectable		 3em0A-4qp0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 10 PHE A  12
PHE A  19
VAL A  51
PHE A  21
PHE A 252
 None
 1.38A 3t3qA-4qp0A:
undetectable		 3t3qA-4qp0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 10 PHE A  12
PHE A  19
VAL A  51
PHE A  21
PHE A 252
 None
 1.45A 3t3qB-4qp0A:
undetectable		 3t3qB-4qp0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 10 PHE A  12
PHE A  19
VAL A  51
PHE A  21
PHE A 252
 None
 1.40A 3t3qC-4qp0A:
undetectable		 3t3qC-4qp0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 ILE A 199
LEU A  56
ILE A 146
VAL A 149
LEU A 150
 None
 0.97A 3w67B-4qp0A:
1.5		 3w67B-4qp0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 ILE A 250
LEU A  56
ILE A 202
ILE A 146
VAL A 149
 None
 1.04A 3w67B-4qp0A:
1.5		 3w67B-4qp0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		4 / 8 ILE A  78
ILE A 146
MET A 117
GLY A 116
 None
 0.98A 4hdlA-4qp0A:
undetectable		 4hdlA-4qp0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		3 / 3 TYR A 114
GLN A 325
TRP A 111
 None
 0.94A 4kn2C-4qp0A:
undetectable		 4kn2C-4qp0A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		4 / 8 ILE A 199
LYS A 200
ILE A 244
ALA A 243
 None
 1.00A 4ou1A-4qp0A:
11.4		 4ou1A-4qp0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		4 / 6 GLY A 218
PHE A 252
ILE A 290
PHE A 168
 None
 1.10A 4qogA-4qp0A:
undetectable
4qogB-4qp0A:
undetectable		 4qogA-4qp0A:
19.71
4qogB-4qp0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 PHE A  12
VAL A  51
ALA A 320
ILE A 172
ILE A 104
 None
 1.15A 5hbsA-4qp0A:
undetectable		 5hbsA-4qp0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 ALA A 279
HIS A 278
ALA A 281
PHE A 223
TYR A 233
 None
 1.17A 5k9dA-4qp0A:
7.8		 5k9dA-4qp0A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4qp0 ENDO-BETA-MANNANASE
(Rhizomucor
miehei) 		5 / 12 HIS A 256
GLY A 253
ALA A 319
ASP A 251
ILE A 250
 None
 1.13A 6b3bA-4qp0A:
undetectable		 6b3bA-4qp0A:
18.87