SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C3S_A_SHHA952_1 (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN))	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 11	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.23A	1c3sA-4qpbA: undetectable	1c3sA-4qpbA: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_CCSB381_0 (ESTROGEN RECEPTOR)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	3 / 3	GLU A 318 ALA A 343 SER A 254	None	0.68A	1errB-4qpbA: undetectable	1errB-4qpbA: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_2 (POL POLYPROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 344 ALA A 294 ILE A 300 ILE A 314 GLY A 348	None	0.85A	1sguB-4qpbA: undetectable	1sguB-4qpbA: 24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T69_A_SHHA379_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.20A	1t69A-4qpbA: undetectable	1t69A-4qpbA: 15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZ1_B_SHHB2552_1 (HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.22A	1zz1B-4qpbA: undetectable 1zz1C-4qpbA: undetectable	1zz1B-4qpbA: 16.94 1zz1C-4qpbA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B7Z_B_MK1B200_2 (HIV-1 PROTEASE)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 344 ALA A 294 ILE A 314 GLY A 348 VAL A 341	None	0.95A	2b7zB-4qpbA: undetectable	2b7zB-4qpbA: 24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C0Z_A_SHHA301_1 (HISTONE DEACETYLASE 7A)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	4 / 5	HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	0.91A	3c0zA-4qpbA: undetectable	3c0zA-4qpbA: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C0Z_C_SHHC301_1 (HISTONE DEACETYLASE 7A)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	4 / 6	HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	0.92A	3c0zC-4qpbA: undetectable	3c0zC-4qpbA: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BZ6_A_SHHA700_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 10	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.21A	4bz6A-4qpbA: undetectable	4bz6A-4qpbA: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BZ6_B_SHHB700_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.18A	4bz6A-4qpbA: undetectable 4bz6B-4qpbA: undetectable	4bz6A-4qpbA: 14.74 4bz6B-4qpbA: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BZ6_C_SHHC700_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.18A	4bz6C-4qpbA: undetectable	4bz6C-4qpbA: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BZ6_C_SHHC700_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.22A	4bz6C-4qpbA: undetectable	4bz6C-4qpbA: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BZ6_D_SHHD700_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 10	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.20A	4bz6D-4qpbA: undetectable	4bz6D-4qpbA: 14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYK_B_IMNB300_1 (LACTOYLGLUTATHIONE LYASE)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	ALA A 375 MET A 366 LEU A 382 GLY A 310 LEU A 361	None	1.23A	4kykA-4qpbA: undetectable 4kykB-4qpbA: undetectable	4kykA-4qpbA: 18.23 4kykB-4qpbA: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_A_SHHA407_1 (HISTONE DEACETYLASE 2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.20A	4lxzA-4qpbA: undetectable	4lxzA-4qpbA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_A_SHHA407_1 (HISTONE DEACETYLASE 2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.18A	4lxzA-4qpbA: undetectable	4lxzA-4qpbA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_B_SHHB408_1 (HISTONE DEACETYLASE 2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 11	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.20A	4lxzB-4qpbA: undetectable	4lxzB-4qpbA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_C_SHHC406_1 (HISTONE DEACETYLASE 2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.21A	4lxzC-4qpbA: undetectable	4lxzC-4qpbA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_C_SHHC406_1 (HISTONE DEACETYLASE 2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.16A	4lxzC-4qpbA: undetectable	4lxzC-4qpbA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_A_SHHA404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.24A	4qa0A-4qpbA: undetectable	4qa0A-4qpbA: 15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_A_SHHA404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.28A	4qa0A-4qpbA: undetectable	4qa0A-4qpbA: 15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_A_SHHA404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.23A	4qa2A-4qpbA: undetectable	4qa2A-4qpbA: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_A_SHHA404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	6 / 12	TYR A 308 HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.46A	4qa2A-4qpbA: undetectable	4qa2A-4qpbA: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_B_SHHB404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.19A	4qa2B-4qpbA: undetectable	4qa2B-4qpbA: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_B_SHHB404_1 (HISTONE DEACETYLASE 8)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.22A	4qa2B-4qpbA: undetectable	4qa2B-4qpbA: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_A_SHHA2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.11A	5eeiA-4qpbA: undetectable	5eeiA-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_A_SHHA2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	6 / 12	SER A 306 HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.41A	5eeiA-4qpbA: undetectable	5eeiA-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_B_SHHB801_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.11A	5eeiB-4qpbA: undetectable	5eeiB-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_B_SHHB801_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	6 / 12	SER A 306 HIS A 360 HIS A 329 GLY A 310 ASP A 283 HIS A 362	None None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.39A	5eeiB-4qpbA: undetectable	5eeiB-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.10A	5eenA-4qpbA: undetectable	5eenA-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	SER A 306 HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.33A	5eenA-4qpbA: undetectable	5eenA-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_B_5OGB804_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.10A	5eenB-4qpbA: undetectable	5eenB-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_B_5OGB804_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	SER A 306 HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.34A	5eenB-4qpbA: undetectable	5eenB-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF8_A_LBHA2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.11A	5ef8A-4qpbA: undetectable	5ef8A-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF8_A_LBHA2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	SER A 306 HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.40A	5ef8A-4qpbA: undetectable	5ef8A-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF8_B_LBHB2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	HIS A 360 HIS A 329 ASP A 283 HIS A 362 TYR A 270	None None ZN A 401 (-2.3A) ZN A 401 (-3.1A) None	1.09A	5ef8B-4qpbA: undetectable	5ef8B-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF8_B_LBHB2004_1 (HDAC6 PROTEIN)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	SER A 306 HIS A 360 HIS A 329 ASP A 283 HIS A 362	None None None ZN A 401 (-2.3A) ZN A 401 (-3.1A)	1.39A	5ef8B-4qpbA: undetectable	5ef8B-4qpbA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JJ0_B_SAMB1205_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.22A	5jj0B-4qpbA: undetectable	5jj0B-4qpbA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T0K_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.25A	5t0kA-4qpbA: undetectable	5t0kA-4qpbA: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T0K_B_SAMB1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.26A	5t0kB-4qpbA: undetectable	5t0kB-4qpbA: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TTF_B_SAMB1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.24A	5ttfB-4qpbA: undetectable	5ttfB-4qpbA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUY_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.18A	5tuyA-4qpbA: undetectable	5tuyA-4qpbA: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUY_B_SAMB1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.15A	5tuyB-4qpbA: undetectable	5tuyB-4qpbA: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V9I_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.22A	5v9iA-4qpbA: undetectable	5v9iA-4qpbA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSC_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.24A	5vscA-4qpbA: undetectable	5vscA-4qpbA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSC_B_SAMB1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.23A	5vscB-4qpbA: undetectable	5vscB-4qpbA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSE_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.22A	5vseA-4qpbA: undetectable	5vseA-4qpbA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSE_B_SAMB1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	4qpb	LYSOSTAPHIN (Staphylococcus simulans)	5 / 12	GLY A 315 HIS A 323 PHE A 381 PHE A 363 GLN A 364	None	1.21A	5vseB-4qpbA: undetectable	5vseB-4qpbA: 17.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C3S_A_SHHA952_1","HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.23A","1c3sA-4qpbA:undetectable","1c3sA-4qpbA:15.86"],["1ERR_B_CCSB381_0","ESTROGEN RECEPTOR","4qpb","LYSOSTAPHIN","Staphylococcus simulans",3,"GLU A 318;ALA A 343;SER A 254","None","0.68A","1errB-4qpbA:undetectable","1errB-4qpbA:17.27"],["1SGU_B_MK1B2632_2","POL POLYPROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 344;ALA A 294;ILE A 300;ILE A 314;GLY A 348","None","0.85A","1sguB-4qpbA:undetectable","1sguB-4qpbA:24.37"],["1T69_A_SHHA379_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.20A","1t69A-4qpbA:undetectable","1t69A-4qpbA:15.04"],["1ZZ1_B_SHHB2552_1","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE;HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.22A","1zz1B-4qpbA:undetectable;1zz1C-4qpbA:undetectable","1zz1B-4qpbA:16.94;1zz1C-4qpbA:16.94"],["2B7Z_B_MK1B200_2","HIV-1 PROTEASE","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 344;ALA A 294;ILE A 314;GLY A 348;VAL A 341","None","0.95A","2b7zB-4qpbA:undetectable","2b7zB-4qpbA:24.37"],["3C0Z_A_SHHA301_1","HISTONE DEACETYLASE 7A","4qpb","LYSOSTAPHIN","Staphylococcus simulans",4,"HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","0.91A","3c0zA-4qpbA:undetectable","3c0zA-4qpbA:14.89"],["3C0Z_C_SHHC301_1","HISTONE DEACETYLASE 7A","4qpb","LYSOSTAPHIN","Staphylococcus simulans",4,"HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","0.92A","3c0zC-4qpbA:undetectable","3c0zC-4qpbA:14.89"],["4BZ6_A_SHHA700_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.21A","4bz6A-4qpbA:undetectable","4bz6A-4qpbA:14.74"],["4BZ6_B_SHHB700_1","HISTONE DEACETYLASE 8;HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.18A","4bz6A-4qpbA:undetectable;4bz6B-4qpbA:undetectable","4bz6A-4qpbA:14.74;4bz6B-4qpbA:14.74"],["4BZ6_C_SHHC700_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.18A","4bz6C-4qpbA:undetectable","4bz6C-4qpbA:14.74"],["4BZ6_C_SHHC700_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.22A","4bz6C-4qpbA:undetectable","4bz6C-4qpbA:14.74"],["4BZ6_D_SHHD700_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.20A","4bz6D-4qpbA:undetectable","4bz6D-4qpbA:14.74"],["4KYK_B_IMNB300_1","LACTOYLGLUTATHIONE LYASE;LACTOYLGLUTATHIONE LYASE","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"ALA A 375;MET A 366;LEU A 382;GLY A 310;LEU A 361","None","1.23A","4kykA-4qpbA:undetectable;4kykB-4qpbA:undetectable","4kykA-4qpbA:18.23;4kykB-4qpbA:18.23"],["4LXZ_A_SHHA407_1","HISTONE DEACETYLASE 2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.20A","4lxzA-4qpbA:undetectable","4lxzA-4qpbA:16.62"],["4LXZ_A_SHHA407_1","HISTONE DEACETYLASE 2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.18A","4lxzA-4qpbA:undetectable","4lxzA-4qpbA:16.62"],["4LXZ_B_SHHB408_1","HISTONE DEACETYLASE 2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.20A","4lxzB-4qpbA:undetectable","4lxzB-4qpbA:16.62"],["4LXZ_C_SHHC406_1","HISTONE DEACETYLASE 2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.21A","4lxzC-4qpbA:undetectable","4lxzC-4qpbA:16.62"],["4LXZ_C_SHHC406_1","HISTONE DEACETYLASE 2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.16A","4lxzC-4qpbA:undetectable","4lxzC-4qpbA:16.62"],["4QA0_A_SHHA404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.24A","4qa0A-4qpbA:undetectable","4qa0A-4qpbA:15.18"],["4QA0_A_SHHA404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.28A","4qa0A-4qpbA:undetectable","4qa0A-4qpbA:15.18"],["4QA2_A_SHHA404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.23A","4qa2A-4qpbA:undetectable","4qa2A-4qpbA:14.92"],["4QA2_A_SHHA404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",6,"TYR A 308;HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.46A","4qa2A-4qpbA:undetectable","4qa2A-4qpbA:14.92"],["4QA2_B_SHHB404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.19A","4qa2B-4qpbA:undetectable","4qa2B-4qpbA:14.92"],["4QA2_B_SHHB404_1","HISTONE DEACETYLASE 8","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.22A","4qa2B-4qpbA:undetectable","4qa2B-4qpbA:14.92"],["5EEI_A_SHHA2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.11A","5eeiA-4qpbA:undetectable","5eeiA-4qpbA:18.79"],["5EEI_A_SHHA2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",6,"SER A 306;HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.41A","5eeiA-4qpbA:undetectable","5eeiA-4qpbA:18.79"],["5EEI_B_SHHB801_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.11A","5eeiB-4qpbA:undetectable","5eeiB-4qpbA:18.79"],["5EEI_B_SHHB801_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",6,"SER A 306;HIS A 360;HIS A 329;GLY A 310;ASP A 283;HIS A 362","None;None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.39A","5eeiB-4qpbA:undetectable","5eeiB-4qpbA:18.79"],["5EEN_A_5OGA804_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.10A","5eenA-4qpbA:undetectable","5eenA-4qpbA:18.79"],["5EEN_A_5OGA804_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"SER A 306;HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.33A","5eenA-4qpbA:undetectable","5eenA-4qpbA:18.79"],["5EEN_B_5OGB804_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.10A","5eenB-4qpbA:undetectable","5eenB-4qpbA:18.79"],["5EEN_B_5OGB804_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"SER A 306;HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.34A","5eenB-4qpbA:undetectable","5eenB-4qpbA:18.79"],["5EF8_A_LBHA2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.11A","5ef8A-4qpbA:undetectable","5ef8A-4qpbA:18.79"],["5EF8_A_LBHA2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"SER A 306;HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.40A","5ef8A-4qpbA:undetectable","5ef8A-4qpbA:18.79"],["5EF8_B_LBHB2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"HIS A 360;HIS A 329;ASP A 283;HIS A 362;TYR A 270","None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A);None","1.09A","5ef8B-4qpbA:undetectable","5ef8B-4qpbA:18.79"],["5EF8_B_LBHB2004_1","HDAC6 PROTEIN","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"SER A 306;HIS A 360;HIS A 329;ASP A 283;HIS A 362","None;None;None; ZN A 401 (-2.3A); ZN A 401 (-3.1A)","1.39A","5ef8B-4qpbA:undetectable","5ef8B-4qpbA:18.79"],["5JJ0_B_SAMB1205_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.22A","5jj0B-4qpbA:undetectable","5jj0B-4qpbA:17.91"],["5T0K_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.25A","5t0kA-4qpbA:undetectable","5t0kA-4qpbA:18.89"],["5T0K_B_SAMB1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.26A","5t0kB-4qpbA:undetectable","5t0kB-4qpbA:18.89"],["5TTF_B_SAMB1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.24A","5ttfB-4qpbA:undetectable","5ttfB-4qpbA:19.05"],["5TUY_A_SAMA1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.18A","5tuyA-4qpbA:undetectable","5tuyA-4qpbA:18.25"],["5TUY_B_SAMB1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.15A","5tuyB-4qpbA:undetectable","5tuyB-4qpbA:18.25"],["5V9I_A_SAMA1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.22A","5v9iA-4qpbA:undetectable","5v9iA-4qpbA:19.05"],["5VSC_A_SAMA1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.24A","5vscA-4qpbA:undetectable","5vscA-4qpbA:17.91"],["5VSC_B_SAMB1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.23A","5vscB-4qpbA:undetectable","5vscB-4qpbA:17.91"],["5VSE_A_SAMA1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.22A","5vseA-4qpbA:undetectable","5vseA-4qpbA:17.91"],["5VSE_B_SAMB1505_0","HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2","4qpb","LYSOSTAPHIN","Staphylococcus simulans",5,"GLY A 315;HIS A 323;PHE A 381;PHE A 363;GLN A 364","None","1.21A","5vseB-4qpbA:undetectable","5vseB-4qpbA:17.91"]]