SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		4 / 7 SER A 862
LEU A 864
GLY A 866
ILE A 924
 None
None
None
ADP  A1501 ( 4.5A)
 1.05A 2bdmA-4qpmA:
undetectable		 2bdmA-4qpmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		6 / 12 LEU A 793
GLY A 794
VAL A 801
LYS A 821
GLU A 830
LEU A 864
 ADP  A1501 ( 3.7A)
ADP  A1501 (-3.3A)
ADP  A1501 (-3.8A)
ADP  A1501 (-2.7A)
ADP  A1501 ( 4.8A)
None
 0.31A 2ivuA-4qpmA:
21.6		 2ivuA-4qpmA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 9 ASP A 987
ILE A 833
GLY A 948
PRO A 741
ILE A 914
 None
None
MG  A1503 ( 4.6A)
None
None
 1.11A 2r5qA-4qpmA:
undetectable		 2r5qA-4qpmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 9 ASP A 987
ILE A 833
GLY A 948
PRO A 741
ILE A 914
 None
None
MG  A1503 ( 4.6A)
None
None
 1.11A 2r5qC-4qpmA:
undetectable		 2r5qC-4qpmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A 857
TRP A 829
TYR A 761
 None
 1.00A 3aicA-4qpmA:
undetectable		 3aicA-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A1036
TRP A 982
TYR A 988
 None
 0.98A 3aicA-4qpmA:
undetectable		 3aicA-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A1036
TRP A 982
TYR A 988
 None
 0.99A 3aicB-4qpmA:
undetectable		 3aicB-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A1036
TRP A 982
TYR A 988
 None
 0.99A 3aicE-4qpmA:
undetectable		 3aicE-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A1036
TRP A 982
TYR A 988
 None
 1.02A 3aicF-4qpmA:
undetectable		 3aicF-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 LEU A1036
TRP A 982
TYR A 988
 None
 0.94A 3aicH-4qpmA:
undetectable		 3aicH-4qpmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		4 / 7 HIS A 856
VAL A 863
VAL A 787
ALA A 804
 None
 1.01A 3kp6B-4qpmA:
1.5		 3kp6B-4qpmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 11 VAL A 908
ILE A 918
GLY A 916
SER A 950
LEU A 947
 None
 1.07A 3n8yA-4qpmA:
undetectable		 3n8yA-4qpmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 12 VAL A 908
ILE A 918
GLY A 916
SER A 950
LEU A 947
 None
 0.97A 3n8zB-4qpmA:
undetectable		 3n8zB-4qpmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 10 VAL A1057
LEU A1054
GLN A 891
LEU A 999
GLU A1030
 None
 1.11A 3qeoA-4qpmA:
undetectable		 3qeoA-4qpmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 SER A 784
GLY A 783
GLN A 781
 None
 0.37A 3v4tH-4qpmA:
undetectable		 3v4tH-4qpmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 8 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.67A 3warA-4qpmA:
19.1		 3warA-4qpmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 12 ALA A 993
PHE A 989
ASP A 946
ASP A 921
HIS A 915
 None
None
MG  A1503 (-1.7A)
None
None
 1.47A 3wemA-4qpmA:
undetectable		 3wemA-4qpmA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 12 ALA A 993
PHE A 989
ASP A 946
ASP A 921
HIS A 915
 None
None
MG  A1503 (-1.7A)
None
None
 1.47A 3weoA-4qpmA:
undetectable		 3weoA-4qpmA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 HIS A1024
GLY A 892
ILE A 895
 None
 0.64A 4k50A-4qpmA:
undetectable		 4k50A-4qpmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 HIS A1024
GLY A 892
ILE A 895
 None
 0.63A 4k50I-4qpmA:
undetectable		 4k50I-4qpmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 12 LEU A 841
ASN A 922
ASP A 987
ILE A 914
HIS A 909
 None
MG  A1502 ( 2.6A)
None
None
None
 1.38A 5dv4A-4qpmA:
undetectable		 5dv4A-4qpmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		3 / 3 MET A 904
GLN A 907
ARG A1051
 None
None
CL  A1504 ( 4.9A)
 1.10A 5ewzB-4qpmA:
2.3		 5ewzB-4qpmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 12 LEU A1050
LEU A 944
LEU A1047
ILE A 913
TYR A 988
 None
 1.09A 5ienB-4qpmA:
undetectable		 5ienB-4qpmA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 8 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.46A 5y9mX-4qpmA:
18.3		 5y9mX-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 7 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.62A 5yf9B-4qpmA:
18.1		 5yf9B-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 9 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.61A 5yf9X-4qpmA:
18.4		 5yf9X-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens) 		5 / 7 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.57A 5ywmX-4qpmA:
18.5		 5ywmX-4qpmA:
11.76