SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.74A 1fm6U-4qpnA:
undetectable		 1fm6U-4qpnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 GLY A 149
LEU A 148
LEU A  82
ILE A  80
ILE A 176
 None
 1.07A 2f8dA-4qpnA:
undetectable		 2f8dA-4qpnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 GLY A 149
LEU A 148
LEU A  82
ILE A  80
ILE A 176
 None
 1.06A 2f8dB-4qpnA:
undetectable		 2f8dB-4qpnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.88A 2idwB-4qpnA:
undetectable		 2idwB-4qpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		4 / 7 GLY A 149
GLY A 164
PHE A 191
PHE A 192
 None
 0.97A 2qwxA-4qpnA:
undetectable
2qwxB-4qpnA:
2.5		 2qwxA-4qpnA:
24.41
2qwxB-4qpnA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 105
ASP A 104
GLY A  85
ALA A  84
GLY A 149
 SAH  A 301 (-4.2A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.3A)
None
None
 1.05A 3ektA-4qpnA:
undetectable		 3ektA-4qpnA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.81A 3ekvA-4qpnA:
undetectable		 3ekvA-4qpnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 ALA A  93
LEU A 148
VAL A  72
ALA A 179
ILE A 215
 None
 1.06A 3fl9F-4qpnA:
2.1		 3fl9F-4qpnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.73A 3h0aA-4qpnA:
undetectable		 3h0aA-4qpnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		3 / 3 GLU A 189
GLU A 209
ASN A 212
 None
 0.90A 3lp9B-4qpnA:
undetectable
3lp9D-4qpnA:
undetectable		 3lp9B-4qpnA:
19.69
3lp9D-4qpnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 11 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.78A 3nu3B-4qpnA:
undetectable		 3nu3B-4qpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.73A 3nu4B-4qpnA:
undetectable		 3nu4B-4qpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.73A 3nujB-4qpnA:
undetectable		 3nujB-4qpnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.77A 3nuoB-4qpnA:
undetectable		 3nuoB-4qpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.71A 3oapA-4qpnA:
undetectable		 3oapA-4qpnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.88A 4dqfB-4qpnA:
undetectable		 4dqfB-4qpnA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		9 / 12 TRP A  57
ALA A  60
GLY A  83
GLY A  85
ASP A 104
LEU A 105
TRP A 133
ALA A 150
TYR A 154
 SAH  A 301 (-4.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.43A 4lg1A-4qpnA:
25.8		 4lg1A-4qpnA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		8 / 12 TRP A  57
ALA A  60
GLY A  83
GLY A  85
LEU A 105
TRP A 133
ALA A 150
TYR A 154
 SAH  A 301 (-4.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.46A 4lg1B-4qpnA:
25.7		 4lg1B-4qpnA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		9 / 12 TRP A  57
ALA A  60
GLY A  83
GLY A  85
ASP A 104
LEU A 105
TRP A 133
ALA A 150
TYR A 154
 SAH  A 301 (-4.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.45A 4lg1C-4qpnA:
25.0		 4lg1C-4qpnA:
32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.76A 4rvjB-4qpnA:
undetectable		 4rvjB-4qpnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 9 LEU A 109
GLY A  83
ALA A  84
ILE A  80
ILE A 112
 None
SAH  A 301 (-3.6A)
None
None
None
 0.75A 4rvjD-4qpnA:
undetectable		 4rvjD-4qpnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 10 ALA A 108
ILE A  91
ILE A  42
VAL A  56
ALA A  53
 SAH  A 301 ( 4.9A)
None
None
SAH  A 301 ( 4.2A)
SAH  A 301 (-3.2A)
 1.05A 5nukA-4qpnA:
undetectable		 5nukA-4qpnA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.77A 6a5yD-4qpnA:
undetectable		 6a5yD-4qpnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.78A 6a5zD-4qpnA:
undetectable		 6a5zD-4qpnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens) 		5 / 12 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.79A 6a5zL-4qpnA:
undetectable		 6a5zL-4qpnA:
17.14