SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 ALA A  80
GLY A  73
GLY A 298
GLY A 299
LEU A  96
 None
None
None
None
SAH  A1000 (-4.0A)
 0.99A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 ALA A  80
GLY A  73
PRO A 297
GLY A 298
GLY A 299
 None
 0.93A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 GLY A  73
PRO A 297
GLY A 298
GLY A 299
LEU A 307
 None
 1.00A 1eizA-4qppA:
7.4		 1eizA-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 ALA A  80
GLY A  73
GLY A 298
GLY A 299
LEU A  96
 None
None
None
None
SAH  A1000 (-4.0A)
 1.00A 1ej0A-4qppA:
7.2		 1ej0A-4qppA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 5 LEU A 353
LEU A 191
ILE A 290
ILE A 341
 36S  A1001 ( 4.5A)
None
None
None
 0.57A 2i2zA-4qppA:
undetectable		 2i2zA-4qppA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 ARG A 204
THR A 227
ALA A 226
PRO A 328
 None
 1.39A 2ql8A-4qppA:
undetectable
2ql8B-4qppA:
undetectable		 2ql8A-4qppA:
17.94
2ql8B-4qppA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 ILE A  95
GLY A  92
ALA A 113
ASP A  88
VAL A  89
 SAH  A1000 (-4.8A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-3.6A)
SAH  A1000 ( 4.2A)
None
 0.99A 2yvlB-4qppA:
9.1		 2yvlB-4qppA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 ALA A  80
GLY A  73
PRO A 297
GLY A 298
GLY A 299
 None
 0.94A 3douA-4qppA:
7.1		 3douA-4qppA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 7 GLY A  90
GLY A  92
GLU A 112
GLU A 141
 SAH  A1000 (-3.2A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-2.7A)
SAH  A1000 (-3.3A)
 0.78A 3fpjB-4qppA:
7.6		 3fpjB-4qppA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 9 ALA A 173
LEU A  87
LEU A 145
VAL A 143
SER A  97
 None
 1.29A 3freX-4qppA:
undetectable		 3freX-4qppA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 4 ASP A 150
GLY A 182
LYS A 179
GLU A 180
 None
 1.43A 3hznD-4qppA:
undetectable		 3hznD-4qppA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 7 ILE A 196
LEU A 325
THR A 335
THR A 227
 None
 1.04A 3nxuA-4qppA:
undetectable		 3nxuA-4qppA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 GLY A  92
THR A  93
GLU A 112
ASP A  88
 SAH  A1000 ( 3.7A)
None
SAH  A1000 (-2.7A)
SAH  A1000 ( 4.2A)
 0.92A 3ps9A-4qppA:
5.3		 3ps9A-4qppA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 GLY A 270
GLY A 272
LEU A 356
GLU A 266
ALA A 269
 36S  A1001 ( 4.7A)
None
None
None
None
 1.17A 3sxjA-4qppA:
8.9		 3sxjA-4qppA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 GLY A 270
GLY A 272
LEU A 356
GLU A 266
ALA A 269
 36S  A1001 ( 4.7A)
None
None
None
None
 1.17A 3sxjB-4qppA:
9.2		 3sxjB-4qppA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 GLY A  92
GLU A 112
ASP A  88
GLU A 141
 SAH  A1000 ( 3.7A)
SAH  A1000 (-2.7A)
SAH  A1000 ( 4.2A)
SAH  A1000 (-3.3A)
 0.87A 3vywC-4qppA:
6.3		 3vywC-4qppA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 9 TYR A 280
CYH A 277
PHE A 312
ILE A 196
 None
 1.16A 4jvlA-4qppA:
undetectable		 4jvlA-4qppA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 GLY A  90
GLY A  92
LEU A  96
ALA A 113
GLU A 141
 SAH  A1000 (-3.2A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-4.0A)
SAH  A1000 (-3.6A)
SAH  A1000 (-3.3A)
 1.06A 5c0oE-4qppA:
8.8		 5c0oE-4qppA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 TYR A 159
ILE A 290
VAL A 238
ALA A 321
 None
 0.93A 5cu6A-4qppA:
undetectable		 5cu6A-4qppA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A  90
LEU A  96
ARG A 174
GLU A 155
 None
SAH  A1000 (-3.2A)
SAH  A1000 (-4.0A)
None
None
 1.40A 5emlA-4qppA:
25.6		 5emlA-4qppA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 PHE A 207
LEU A 205
TRP A 208
SER A 209
 None
 0.97A 5o4yF-4qppA:
undetectable		 5o4yF-4qppA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6
(Homo
sapiens) 		4 / 6 GLU A 112
TRP A 117
ALA A 120
GLN A 119
 SAH  A1000 (-2.7A)
None
None
None
 1.32A 6f6jC-4qppA:
undetectable
6f6jD-4qppA:
undetectable		 6f6jC-4qppA:
22.95
6f6jD-4qppA:
22.95