SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		4 / 4 GLY A 196
ASP A 193
GLY A 190
THR A 289
 None
 0.90A 1hxbB-4qpwA:
undetectable		 1hxbB-4qpwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		5 / 12 ILE A 212
GLY A 288
ILE A 290
THR A 187
GLU A 182
 None
 1.15A 1sg9A-4qpwA:
undetectable		 1sg9A-4qpwA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		3 / 3 SER A 269
ASP A 163
ASP A 160
 None
 0.77A 2plwA-4qpwA:
undetectable		 2plwA-4qpwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		4 / 8 ILE A 297
PHE A 270
GLY A 277
GLY A 276
 None
 0.87A 2qx4A-4qpwA:
undetectable
2qx4B-4qpwA:
undetectable		 2qx4A-4qpwA:
20.09
2qx4B-4qpwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		4 / 6 ILE A 297
PHE A 270
GLY A 277
GLY A 276
 None
 0.84A 2qx6A-4qpwA:
undetectable
2qx6B-4qpwA:
undetectable		 2qx6A-4qpwA:
20.09
2qx6B-4qpwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		4 / 4 GLY A 196
ASP A 193
GLY A 190
THR A 289
 None
 0.94A 3k4vC-4qpwA:
undetectable		 3k4vC-4qpwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4qpw GLYCOSYL HYDROLASE
FAMILY 10
(Bacteroides
intestinalis) 		5 / 12 LEU A 242
GLY A 255
GLY A 245
VAL A 279
THR A 281
 None
 1.25A 5o4yD-4qpwA:
undetectable
5o4yE-4qpwA:
undetectable		 5o4yD-4qpwA:
7.83
5o4yE-4qpwA:
18.06