SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 11 PHE D 201
VAL D 338
LEU D 351
LEU D 342
LEU D 323
 None
 1.21A 1mx1B-4qqfD:
undetectable		 1mx1B-4qqfD:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.09A 3vywA-4qqfD:
undetectable		 3vywA-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.09A 3vywB-4qqfD:
undetectable		 3vywB-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.08A 3vywC-4qqfD:
undetectable		 3vywC-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.04A 3vywD-4qqfD:
undetectable		 3vywD-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 323
PHE D 224
TYR D 232
PRO D 325
ASP D 222
 None
None
None
None
MG  D 401 ( 4.4A)
 1.34A 4j7xA-4qqfD:
undetectable		 4j7xA-4qqfD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 323
PHE D 224
TYR D 232
PRO D 325
ASP D 222
 None
None
None
None
MG  D 401 ( 4.4A)
 1.36A 4j7xF-4qqfD:
undetectable		 4j7xF-4qqfD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 323
PHE D 224
TYR D 232
PRO D 325
ASP D 222
 None
None
None
None
MG  D 401 ( 4.4A)
 1.30A 4j7xJ-4qqfD:
undetectable		 4j7xJ-4qqfD:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		4 / 6 LEU D 327
ILE D 324
LEU D 228
TYR D 232
 None
 0.89A 4w5nA-4qqfD:
undetectable		 4w5nA-4qqfD:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50
(Saccharomyces
cerevisiae) 		3 / 3 LEU D 351
ILE D 307
TYR D 232
 None
 0.65A 5uunB-4qqfD:
undetectable		 5uunB-4qqfD:
21.33