SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 4 LYS A  30
LEU A  27
LEU A 204
SER A 207
 None
 1.32A 1tt6A-4qqrA:
undetectable		 1tt6A-4qqrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 4 LYS A  30
LEU A  27
LEU A 204
SER A 207
 None
 1.29A 1tz8D-4qqrA:
undetectable		 1tz8D-4qqrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  97
ASP A  55
ILE A  52
GLY A  42
GLY A  25
 None
 1.09A 1zz1C-4qqrA:
2.9		 1zz1C-4qqrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 5 PRO A 194
VAL A 226
THR A 113
GLY A 114
 None
 1.15A 3elzB-4qqrA:
undetectable		 3elzB-4qqrA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 7 GLY A 225
CYH A 115
PHE A 139
GLY A 130
 None
ZN  A 404 (-2.9A)
None
None
 0.96A 3ko0M-4qqrA:
undetectable
3ko0P-4qqrA:
undetectable		 3ko0M-4qqrA:
14.01
3ko0P-4qqrA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 225
PHE A 139
GLY A 130
PHE A 131
 None
 1.00A 3ko0O-4qqrA:
undetectable
3ko0Q-4qqrA:
undetectable		 3ko0O-4qqrA:
14.01
3ko0Q-4qqrA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 6 VAL A  64
ASN A 160
TYR A  18
ILE A 100
 None
 1.12A 3q5sA-4qqrA:
undetectable		 3q5sA-4qqrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  19
GLY A  42
PHE A  65
ALA A  68
ASN A  66
 None
 1.30A 3t7sB-4qqrA:
2.8		 3t7sB-4qqrA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 7 THR A 113
LEU A  95
ASN A  66
LEU A 108
 None
 0.95A 4ib4A-4qqrA:
undetectable		 4ib4A-4qqrA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		5 / 11 ALA A  68
ALA A  67
THR A  71
VAL A 166
LEU A 164
 None
None
SO4  A 406 (-3.7A)
None
None
 1.13A 4j6cA-4qqrA:
undetectable		 4j6cA-4qqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		5 / 10 ALA A  68
ALA A  67
THR A  71
VAL A 166
LEU A 164
 None
None
SO4  A 406 (-3.7A)
None
None
 1.14A 4j6cB-4qqrA:
undetectable		 4j6cB-4qqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		3 / 3 ASP A  99
VAL A  91
ASN A 160
 None
 0.77A 4lmnA-4qqrA:
undetectable		 4lmnA-4qqrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		3 / 3 THR A 222
THR A 198
PHE A 180
 None
 0.80A 5cxvA-4qqrA:
undetectable		 5cxvA-4qqrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		3 / 3 THR A 163
ALA A 112
ASN A 110
 None
 0.64A 5ersA-4qqrA:
3.0		 5ersA-4qqrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 5 GLU A 209
GLU A 275
GLU A 278
PHE A 276
 None
 0.95A 5onlA-4qqrA:
1.9		 5onlA-4qqrA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 4qqr 3,5-EPIMERASE/4-REDU
CTASE
(Arabidopsis
thaliana) 		4 / 5 GLU A 209
GLU A 275
GLU A 278
PHE A 276
 None
 0.96A 6hrjA-4qqrA:
2.2		 6hrjA-4qqrA:
22.26