SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 HIS A 273
GLY A 255
ASN A 257
GLY A 196
ASP A 126
 None
None
None
NA  A 402 ( 4.6A)
EPE  A 401 (-2.7A)
 1.22A 1ffyA-4qqsA:
undetectable		 1ffyA-4qqsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 TYR A 138
LEU A 167
TYR A  84
ILE A 129
PHE A  78
 None
 1.25A 1fmlA-4qqsA:
undetectable		 1fmlA-4qqsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 8 GLY A  38
SER A  88
ASP A 126
ASP A  17
 None
None
EPE  A 401 (-2.7A)
EPE  A 401 (-3.5A)
 0.73A 1m4iA-4qqsA:
undetectable		 1m4iA-4qqsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 PRO A  18
THR A 286
VAL A 287
LEU A  47
ILE A 289
 None
 1.27A 2fj1A-4qqsA:
undetectable		 2fj1A-4qqsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 6 TYR A 206
VAL A 199
TYR A 140
ASP A 132
 None
 1.11A 2x45A-4qqsA:
undetectable		 2x45A-4qqsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 7 TYR A 206
VAL A 199
TYR A 140
ASP A 132
 None
 1.10A 2x45B-4qqsA:
undetectable		 2x45B-4qqsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 7 TYR A 206
VAL A 199
TYR A 140
ASP A 132
 None
 1.11A 2x45C-4qqsA:
undetectable		 2x45C-4qqsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		3 / 3 GLU A 162
ASP A 132
TYR A 206
 None
 0.81A 2yvlB-4qqsA:
undetectable		 2yvlB-4qqsA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 6 MET A  85
ARG A  37
GLY A  65
TRP A  66
 None
 1.47A 3aqiB-4qqsA:
undetectable		 3aqiB-4qqsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 7 TYR A 206
VAL A 199
TYR A 140
ASP A 132
 None
 1.10A 3bu1A-4qqsA:
undetectable		 3bu1A-4qqsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 8 TYR A   5
LEU A  47
GLY A  11
THR A 274
 None
 0.81A 3jusA-4qqsA:
undetectable		 3jusA-4qqsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 8 TYR A   5
LEU A  47
GLY A  11
THR A 274
 None
 0.81A 3jusA-4qqsA:
undetectable		 3jusA-4qqsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		3 / 3 LYS A 302
SER A 307
GLN A 309
 None
 1.37A 3si7A-4qqsA:
undetectable		 3si7A-4qqsA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 10 TYR A 140
VAL A 199
TYR A 206
TYR A 210
ILE A 178
 None
 1.32A 3vriA-4qqsA:
undetectable
3vriC-4qqsA:
undetectable		 3vriA-4qqsA:
20.26
3vriC-4qqsA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 4 TYR A 272
THR A 286
VAL A   9
ILE A 251
 None
 1.43A 4jx1F-4qqsA:
undetectable		 4jx1F-4qqsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 PHE A  78
ALA A  99
ALA A 101
ASN A 112
TYR A  87
 None
 1.34A 4pclB-4qqsA:
undetectable		 4pclB-4qqsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 6 PHE A 118
LEU A 100
ASN A 112
ARG A 120
 None
 1.26A 4yv5B-4qqsA:
undetectable		 4yv5B-4qqsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		4 / 6 ILE A 242
VAL A 270
TYR A 293
VAL A 301
 None
 0.94A 5jwaH-4qqsA:
undetectable		 5jwaH-4qqsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 ILE A 222
TYR A 272
GLY A 255
SER A 221
VAL A 301
 None
 1.10A 5n0oA-4qqsA:
undetectable		 5n0oA-4qqsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4qqs GLYCOSIDE HYDROLASE
FAMILY 43
(Halothermothrix
orenii) 		5 / 12 ILE A 222
TYR A 272
GLY A 255
SER A 221
VAL A 301
 None
 1.11A 5n0oB-4qqsA:
undetectable		 5n0oB-4qqsA:
21.20