SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 TYR A 123
THR A 133
SER A 128
TRP A 237
 None
3BG  A 601 (-3.7A)
None
None
 1.41A 1eiiA-4qreA:
undetectable		 1eiiA-4qreA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 ASN A 229
LEU A 113
LEU A 120
SER A 216
 None
 1.10A 1hk3A-4qreA:
undetectable		 1hk3A-4qreA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 THR A 371
VAL A 368
LEU A 367
LEU A 471
LEU A 364
LEU A 470
 None
 1.19A 1mx1C-4qreA:
undetectable		 1mx1C-4qreA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  20
GLY A  22
HIS A  23
ILE A 273
HIS A 299
 ATP  A 602 (-4.5A)
ATP  A 602 (-3.6A)
ATP  A 602 (-3.9A)
3BG  A 601 ( 3.9A)
ATP  A 602 (-4.6A)
 0.52A 1pg2A-4qreA:
38.6		 1pg2A-4qreA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  20
GLY A  22
HIS A  23
HIS A 299
MET A 304
 ATP  A 602 (-4.5A)
ATP  A 602 (-3.6A)
ATP  A 602 (-3.9A)
ATP  A 602 (-4.6A)
None
 1.00A 1qu2A-4qreA:
24.1		 1qu2A-4qreA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ILE A  76
ILE A  79
LYS A  80
THR A  48
 None
 0.92A 1sbrB-4qreA:
undetectable		 1sbrB-4qreA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A  48
PRO A  11
TYR A  13
 None
ATP  A 602 ( 4.3A)
ATP  A 602 (-4.5A)
 0.97A 2dxrA-4qreA:
undetectable		 2dxrA-4qreA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 PRO A 156
PRO A 143
ILE A 150
GLY A 153
 None
 0.99A 2jkjD-4qreA:
undetectable		 2jkjD-4qreA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 PRO A 156
PRO A 143
ILE A 150
GLY A 153
 None
 1.00A 2jkjF-4qreA:
undetectable		 2jkjF-4qreA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ILE A  76
GLU A  98
ALA A 247
ASP A  92
PHE A  93
 None
 1.29A 2noaB-4qreA:
undetectable		 2noaB-4qreA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  20
GLY A  22
HIS A  23
ILE A 273
HIS A 299
 ATP  A 602 (-4.5A)
ATP  A 602 (-3.6A)
ATP  A 602 (-3.9A)
3BG  A 601 ( 3.9A)
ATP  A 602 (-4.6A)
 0.47A 2x1lA-4qreA:
42.8		 2x1lA-4qreA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  20
GLY A  22
HIS A  23
ILE A 273
HIS A 299
 ATP  A 602 (-4.5A)
ATP  A 602 (-3.6A)
ATP  A 602 (-3.9A)
3BG  A 601 ( 3.9A)
ATP  A 602 (-4.6A)
 0.44A 2x1lB-4qreA:
45.5		 2x1lB-4qreA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  20
GLY A  22
HIS A  23
ILE A 273
HIS A 299
 ATP  A 602 (-4.5A)
ATP  A 602 (-3.6A)
ATP  A 602 (-3.9A)
3BG  A 601 ( 3.9A)
ATP  A 602 (-4.6A)
 0.49A 2x1lC-4qreA:
45.2		 2x1lC-4qreA:
43.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 ALA A 330
ALA A  24
TYR A  25
MET A 309
 None
 1.10A 3d91A-4qreA:
undetectable		 3d91A-4qreA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLN A  40
TYR A  36
PRO A 473
LEU A 470
 None
 1.37A 3tgvB-4qreA:
undetectable		 3tgvB-4qreA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ALA A 478
PRO A 479
ARG A 465
ALA A 467
 None
 0.97A 3twpC-4qreA:
2.6		 3twpC-4qreA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 VAL A  28
ILE A 323
ALA A 330
ILE A 321
 None
 0.86A 4uxqA-4qreA:
undetectable		 4uxqA-4qreA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A 476
HIS A  23
LEU A  82
 None
ATP  A 602 (-3.9A)
None
 0.66A 5axdA-4qreA:
undetectable		 5axdA-4qreA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 TYR A  13
ILE A  88
TRP A  83
TYR A  46
ILE A   8
 ATP  A 602 (-4.5A)
None
None
None
None
 1.23A 5hw8E-4qreA:
undetectable		 5hw8E-4qreA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 TYR A  13
ILE A  88
TRP A  83
TYR A  46
ILE A   8
 ATP  A 602 (-4.5A)
None
None
None
None
 1.14A 5hw8G-4qreA:
undetectable		 5hw8G-4qreA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 THR A  96
ASP A  51
ASP A 239
GLY A  54
 None
3BG  A 601 (-2.8A)
3BG  A 601 (-4.3A)
3BG  A 601 (-3.5A)
 0.94A 5hwaA-4qreA:
undetectable		 5hwaA-4qreA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ILE A 482
LEU A 486
THR A 371
ARG A 370
ILE A 372
 None
 1.16A 5ifuB-4qreA:
2.1		 5ifuB-4qreA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 TYR A 127
ARG A 217
TYR A 235
TYR A  14
 None
None
3BG  A 601 (-4.7A)
3BG  A 601 (-3.5A)
 1.40A 5igyA-4qreA:
undetectable		 5igyA-4qreA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 LEU A 470
MET A 412
ILE A 428
LEU A 421
 None
 1.38A 5nfpA-4qreA:
undetectable		 5nfpA-4qreA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A  10
MET A 269
HIS A 299
 None
None
ATP  A 602 (-4.6A)
 1.01A 5uunA-4qreA:
3.1		 5uunA-4qreA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 VAL A 316
ASN A 320
PRO A 319
ILE A 321
 None
 1.13A 6h7uA-4qreA:
3.3		 6h7uA-4qreA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4qre METHIONYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A 299
LEU A  19
HIS A  23
GLY A  22
ALA A  29
 ATP  A 602 (-4.6A)
None
ATP  A 602 (-3.9A)
ATP  A 602 (-3.6A)
None
 1.11A 6ieyA-4qreA:
2.4
6ieyB-4qreA:
2.5		 6ieyA-4qreA:
19.61
6ieyB-4qreA:
19.61