SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		3 / 3 HIS A  10
ASP A 170
ASN A 167
 None
 0.80A 1wg8B-4qriA:
undetectable		 1wg8B-4qriA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		3 / 3 TYR A 111
HIS A 115
ARG A 114
 None
 1.12A 4e7bC-4qriA:
undetectable		 4e7bC-4qriA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		4 / 7 PHE A 117
ILE A  39
PRO A 121
HIS A  95
 None
 1.08A 4g5jA-4qriA:
undetectable		 4g5jA-4qriA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		5 / 10 LEU A  27
PRO A  59
GLU A  31
PHE A  40
LEU A  54
 None
 1.42A 4la0A-4qriA:
undetectable		 4la0A-4qriA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		5 / 9 LEU A  27
PRO A  59
GLU A  31
PHE A  40
LEU A  54
 None
 1.41A 4la0B-4qriA:
undetectable		 4la0B-4qriA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		5 / 11 GLY A  47
PHE A  40
ILE A  39
ASN A  65
TYR A  33
 None
 1.18A 4rtrA-4qriA:
3.9		 4rtrA-4qriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		5 / 12 GLY A  47
PHE A  40
ILE A  39
ASN A  65
TYR A  33
 None
 1.17A 4rtsA-4qriA:
2.8		 4rtsA-4qriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		3 / 3 GLY A 156
LEU A 168
HIS A 172
 None
 0.63A 5u63A-4qriA:
undetectable		 5u63A-4qriA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leptospira
interrogans) 		3 / 3 GLY A 156
LEU A 168
HIS A 172
 None
 0.67A 5u63B-4qriA:
undetectable		 5u63B-4qriA:
21.65