SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Thermotoga
maritima) 		4 / 5 LEU B 150
PRO B 151
LEU B 154
ILE B 131
 None
 0.76A 2qd4A-4qrmB:
undetectable		 2qd4A-4qrmB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		3 / 3 PHE A  55
LYS A 226
SER A 228
 None
 1.15A 3tyeB-4qrmA:
undetectable		 3tyeB-4qrmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 7 VAL A 109
HIS A  59
LEU A 196
LEU A 219
 None
 0.97A 4l1wA-4qrmA:
undetectable		 4l1wA-4qrmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 8 LEU A 227
HIS A  59
LEU A 196
LEU A 219
 None
 0.95A 4l1xA-4qrmA:
undetectable		 4l1xA-4qrmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 8 VAL A 109
HIS A  59
LEU A 196
LEU A 219
 None
 0.93A 4l1xA-4qrmA:
undetectable		 4l1xA-4qrmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 6 LEU A 223
ASP A 108
GLU A 111
ALA A 114
 None
 0.94A 4nkxA-4qrmA:
undetectable		 4nkxA-4qrmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		5 / 11 ILE A 188
THR A 106
SER A 113
GLY A 112
GLU A 177
 None
 0.94A 4xt7A-4qrmA:
undetectable		 4xt7A-4qrmA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 6 ILE A  93
PHE A  92
ILE A 102
GLU A 117
 None
 0.88A 4zzcA-4qrmA:
undetectable
4zzcB-4qrmA:
undetectable		 4zzcA-4qrmA:
20.70
4zzcB-4qrmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 6 ILE A  93
PHE A  92
ILE A 102
GLU A 117
 None
 0.90A 4zzcB-4qrmA:
undetectable
4zzcC-4qrmA:
undetectable		 4zzcB-4qrmA:
20.70
4zzcC-4qrmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 6 PHE A 123
GLU A 147
GLU B 175
VAL B 172
 None
 1.24A 5h4dA-4qrmA:
undetectable		 5h4dA-4qrmA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		4 / 8 GLU A 136
VAL B 158
GLY A 132
LEU B 165
 None
 0.95A 5sxqB-4qrmA:
undetectable		 5sxqB-4qrmA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM
(Thermotoga
maritima) 		3 / 3 GLY A 112
THR A 106
GLU A 177
 None
 0.63A 6b58A-4qrmA:
undetectable		 6b58A-4qrmA:
14.61