SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 LEU A 135
ILE A 199
GLU A 201
ASP A 141
 None
 1.23A 1ditH-4qs9A:
undetectable
1ditP-4qs9A:
undetectable		 1ditH-4qs9A:
21.25
1ditP-4qs9A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 LEU A 442
GLY A 406
ALA A 407
SER A 410
GLY A 413
 None
 0.77A 1fe2A-4qs9A:
undetectable		 1fe2A-4qs9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 LEU A 442
GLY A 406
ALA A 407
SER A 410
GLY A 413
 None
 0.78A 1igxA-4qs9A:
undetectable		 1igxA-4qs9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 TYR A 240
TYR A 241
GLU A  93
VAL A 112
 None
 1.39A 1q13A-4qs9A:
undetectable		 1q13A-4qs9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 VAL A 228
LEU A  88
GLY A 481
ALA A 482
LEU A 185
 None
 0.81A 1r9oA-4qs9A:
undetectable		 1r9oA-4qs9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		3 / 3 ILE A 317
ASP A  47
PHE A  44
 None
 0.54A 1uwjB-4qs9A:
undetectable		 1uwjB-4qs9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		3 / 3 MET A  62
ASN A 256
GLN A 312
 None
BGC  A 501 (-3.7A)
BGC  A 501 ( 4.4A)
 0.77A 1xoqB-4qs9A:
undetectable		 1xoqB-4qs9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 5 LEU A 293
ILE A 318
SER A 410
GLY A 413
 None
 0.96A 2otfA-4qs9A:
undetectable		 2otfA-4qs9A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 9 LEU A 302
ASP A 299
GLY A 406
ILE A 318
ILE A 326
 None
 1.15A 3d1yB-4qs9A:
undetectable		 3d1yB-4qs9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 7 PHE A 178
PHE A 176
GLY A 254
PHE A 144
 None
None
BGC  A 501 ( 3.7A)
None
 1.10A 3ko0K-4qs9A:
undetectable
3ko0S-4qs9A:
undetectable		 3ko0K-4qs9A:
11.11
3ko0S-4qs9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		3 / 3 ARG A 405
LEU A 409
THR A 255
 None
 0.78A 3oxcA-4qs9A:
undetectable		 3oxcA-4qs9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 PHE A 174
ASN A 212
PHE A 144
ALA A 214
 None
 1.10A 3t3sB-4qs9A:
undetectable		 3t3sB-4qs9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 LEU A 421
LEU A 460
LEU A 461
ALA A  59
ALA A 412
 None
 1.00A 3vw7A-4qs9A:
undetectable		 3vw7A-4qs9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 SER A 140
ASP A 141
ILE A 199
PHE A 144
 None
 1.07A 4acbC-4qs9A:
undetectable		 4acbC-4qs9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 SER A 140
ASP A 141
THR A 137
ILE A 199
 None
 1.08A 4acbC-4qs9A:
undetectable		 4acbC-4qs9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 GLY A 254
GLY A 252
GLU A 315
ILE A 318
 BGC  A 501 ( 3.7A)
None
BGC  A 501 (-2.7A)
None
 0.92A 4fglD-4qs9A:
undetectable		 4fglD-4qs9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 11 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.05A 4j6cA-4qs9A:
1.2		 4j6cA-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 10 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.06A 4j6cB-4qs9A:
undetectable		 4j6cB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.03A 4j6dA-4qs9A:
undetectable		 4j6dA-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.03A 4j6dB-4qs9A:
undetectable		 4j6dB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.04A 4jbtA-4qs9A:
undetectable		 4jbtA-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 11 ALA A 257
ALA A 248
ALA A 247
VAL A 469
LEU A 457
 None
 1.04A 4jbtB-4qs9A:
undetectable		 4jbtB-4qs9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 VAL A 374
PHE A 341
LEU A 349
VAL A 395
LEU A 327
 None
 1.25A 4po0A-4qs9A:
undetectable		 4po0A-4qs9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 9 THR A 175
ALA A 226
ALA A 225
VAL A 232
GLY A 481
 None
 1.14A 4qvnK-4qs9A:
undetectable
4qvnL-4qs9A:
undetectable		 4qvnK-4qs9A:
17.65
4qvnL-4qs9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 9 THR A 175
ALA A 226
ALA A 225
VAL A 232
GLY A 481
 None
 1.14A 4qvnY-4qs9A:
undetectable
4qvnZ-4qs9A:
undetectable		 4qvnY-4qs9A:
17.65
4qvnZ-4qs9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 11 LEU A 172
LEU A 215
GLU A 149
ALA A 150
LEU A 151
 None
 1.05A 4wg0J-4qs9A:
undetectable
4wg0K-4qs9A:
undetectable
4wg0L-4qs9A:
undetectable		 4wg0J-4qs9A:
2.53
4wg0K-4qs9A:
2.53
4wg0L-4qs9A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 5 SER A 488
ALA A 487
HIS A 489
LEU A 485
 None
 0.97A 5dzkb-4qs9A:
undetectable
5dzkp-4qs9A:
undetectable		 5dzkb-4qs9A:
17.92
5dzkp-4qs9A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 6 SER A 488
ALA A 487
HIS A 489
LEU A 485
 None
 0.97A 5dzkB-4qs9A:
undetectable
5dzkP-4qs9A:
undetectable		 5dzkB-4qs9A:
17.92
5dzkP-4qs9A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		4 / 5 SER A 488
ALA A 487
HIS A 489
LEU A 485
 None
 0.96A 5dzkc-4qs9A:
undetectable
5dzkq-4qs9A:
undetectable		 5dzkc-4qs9A:
17.92
5dzkq-4qs9A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 VAL A 228
LEU A  88
GLY A 481
ALA A 482
LEU A 185
 None
 0.71A 5x23A-4qs9A:
undetectable		 5x23A-4qs9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		6 / 12 GLU A  93
LEU A 172
ALA A 486
SER A 488
ARG A 108
GLY A 237
 None
 1.35A 6b0cD-4qs9A:
undetectable		 6b0cD-4qs9A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		5 / 12 ALA A 248
GLY A 481
GLY A 237
VAL A 232
ASP A 101
 None
 1.18A 6clxA-4qs9A:
undetectable		 6clxA-4qs9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4qs9 HEXOKINASE-1
(Arabidopsis
thaliana) 		3 / 3 ASP A 303
LEU A 302
ARG A 405
 None
 0.89A 7dfrA-4qs9A:
undetectable		 7dfrA-4qs9A:
16.49