SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		3 / 3 TRP A-213
VAL A-112
TRP A -31
 None
None
GLC  A 902 ( 3.6A)
 1.24A 1c4dA-4qszA:
undetectable
1c4dB-4qszA:
undetectable		 1c4dA-4qszA:
2.08
1c4dB-4qszA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 6 VAL A-363
VAL A-321
ILE A-311
ASN A-104
 None
 0.81A 1e06A-4qszA:
undetectable		 1e06A-4qszA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M6E_X_SALX2000_1
(S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 7 LYS A 193
TRP A 167
TYR A 127
VAL A 279
 None
 1.33A 1m6eX-4qszA:
0.1		 1m6eX-4qszA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 7 LYS A -94
GLU A -90
ALA A -95
ALA A-294
 None
 1.15A 1sn0B-4qszA:
undetectable
1sn0D-4qszA:
undetectable		 1sn0B-4qszA:
12.93
1sn0D-4qszA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.12A 2f16H-4qszA:
undetectable
2f16I-4qszA:
undetectable		 2f16H-4qszA:
15.03
2f16I-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A-278
GLN A -46
ALA A -47
ALA A -68
ALA A -70
 None
 1.14A 2f16H-4qszA:
undetectable
2f16I-4qszA:
undetectable		 2f16H-4qszA:
15.03
2f16I-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.13A 2f16V-4qszA:
undetectable
2f16W-4qszA:
undetectable		 2f16V-4qszA:
15.03
2f16W-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A-278
GLN A -46
ALA A -47
ALA A -68
ALA A -70
 None
 1.13A 2f16V-4qszA:
undetectable
2f16W-4qszA:
undetectable		 2f16V-4qszA:
15.03
2f16W-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 8 GLY A-270
ASN A-271
ILE A-193
VAL A   9
 None
 0.75A 2yoeB-4qszA:
undetectable
2yoeC-4qszA:
undetectable		 2yoeB-4qszA:
18.68
2yoeC-4qszA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 8 THR A-278
LEU A -86
ASP A -84
GLU A-260
 None
None
None
GLC  A 901 (-3.1A)
 1.06A 2zw9A-4qszA:
undetectable		 2zw9A-4qszA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 6 PHE A-113
ALA A-209
LEU A-124
PRO A-212
 None
 0.99A 3bgdA-4qszA:
undetectable		 3bgdA-4qszA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 7 VAL A-261
GLY A -71
PRO A-142
LYS A -66
 None
 0.70A 3bjwC-4qszA:
undetectable		 3bjwC-4qszA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A -28
GLY A-184
ALA A-183
LEU A-179
LEU A-211
 None
 1.05A 3hs6A-4qszA:
undetectable		 3hs6A-4qszA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		12 / 12 ASP A-357
LYS A-356
LYS A-329
GLU A-327
GLU A-326
ALA A-308
ASP A-306
ARG A-305
GLU A-260
PRO A-217
TRP A-141
TYR A -30
 GLC  A 901 (-2.9A)
GLC  A 901 (-3.0A)
None
FLC  A 903 (-3.9A)
FLC  A 903 (-3.5A)
GLC  A 902 (-3.1A)
GLC  A 902 (-2.9A)
FLC  A 903 (-3.9A)
GLC  A 901 (-3.1A)
GLC  A 902 ( 3.7A)
GLC  A 901 (-4.0A)
FLC  A 903 (-3.9A)
 0.39A 3jyrA-4qszA:
60.3		 3jyrA-4qszA:
50.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		6 / 7 ASN A-359
TRP A-309
GLU A-218
TYR A-216
MET A -41
TRP A -31
 GLC  A 901 (-4.7A)
GLC  A 902 (-3.9A)
FLC  A 903 (-3.0A)
GLC  A 901 ( 3.8A)
GLC  A 902 ( 4.1A)
GLC  A 902 ( 3.6A)
 0.19A 3jyrA-4qszA:
60.3		 3jyrA-4qszA:
50.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 7 GLU A-218
TYR A-216
MET A -41
TRP A -31
ARG A -27
 FLC  A 903 (-3.0A)
GLC  A 901 ( 3.8A)
GLC  A 902 ( 4.1A)
GLC  A 902 ( 3.6A)
FLC  A 903 (-2.9A)
 0.90A 3jyrA-4qszA:
60.3		 3jyrA-4qszA:
50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 10 THR A 175
HIS A 178
ASP A 180
LYS A 193
HIS A 277
 None
 0.67A 3kcxA-4qszA:
21.6		 3kcxA-4qszA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 10 TYR A 127
THR A 175
HIS A 178
ASP A 180
HIS A 277
 None
 1.29A 3kcxA-4qszA:
21.6		 3kcxA-4qszA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.14A 3mg0H-4qszA:
undetectable
3mg0I-4qszA:
undetectable		 3mg0H-4qszA:
15.03
3mg0I-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.17A 3mg0V-4qszA:
undetectable
3mg0W-4qszA:
undetectable		 3mg0V-4qszA:
15.03
3mg0W-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A-278
GLN A -46
ALA A -47
ALA A -68
ALA A -70
 None
 1.17A 3mg0V-4qszA:
undetectable
3mg0W-4qszA:
undetectable		 3mg0V-4qszA:
15.03
3mg0W-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A-175
LEU A-211
GLY A-184
ALA A-183
LEU A -10
 None
 0.99A 3n8yB-4qszA:
undetectable		 3n8yB-4qszA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A-215
GLY A -71
LEU A -72
GLU A-260
ALA A-140
 GLC  A 901 (-4.8A)
None
None
GLC  A 901 (-3.1A)
None
 0.95A 3tbgB-4qszA:
undetectable		 3tbgB-4qszA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A-215
GLY A -71
LEU A -72
GLU A-260
ALA A-140
 GLC  A 901 (-4.8A)
None
None
GLC  A 901 (-3.1A)
None
 0.95A 3tbgD-4qszA:
undetectable		 3tbgD-4qszA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 ALA A-140
ASP A -75
TYR A-161
ASN A-137
GLY A-143
 None
 1.30A 3vwrA-4qszA:
undetectable		 3vwrA-4qszA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 7 PRO A -40
ALA A-203
LYS A-115
TYR A-216
 None
None
None
GLC  A 901 ( 3.8A)
 0.91A 4lb2A-4qszA:
undetectable		 4lb2A-4qszA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 5 ASN A-104
ALA A-320
GLY A-315
ASP A-357
 None
None
None
GLC  A 901 (-2.9A)
 1.01A 4n48A-4qszA:
undetectable		 4n48A-4qszA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 9 ALA A-107
ALA A-266
LEU A-268
LEU A-109
VAL A-110
 None
 1.16A 4or0B-4qszA:
undetectable		 4or0B-4qszA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 7 LEU A-295
GLY A-106
ALA A-107
SER A-108
 None
 0.89A 5f1aB-4qszA:
undetectable		 5f1aB-4qszA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.21A 5l5fH-4qszA:
undetectable
5l5fI-4qszA:
undetectable		 5l5fH-4qszA:
15.03
5l5fI-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.22A 5l5fV-4qszA:
undetectable
5l5fW-4qszA:
undetectable		 5l5fV-4qszA:
15.03
5l5fW-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.13A 5l66H-4qszA:
undetectable
5l66I-4qszA:
undetectable		 5l66H-4qszA:
15.03
5l66I-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 12 GLN A-322
ALA A-102
GLY A-317
THR A-318
ALA A-319
 None
 1.13A 5l66V-4qszA:
undetectable
5l66W-4qszA:
undetectable		 5l66V-4qszA:
15.03
5l66W-4qszA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 6 ASN A  24
ALA A  20
PRO A 199
VAL A  25
 None
 1.21A 5umd2-4qszA:
undetectable
5umdF-4qszA:
undetectable		 5umd2-4qszA:
8.56
5umdF-4qszA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		6 / 12 ALA A -29
ALA A -33
GLY A-205
ALA A-183
PHE A-202
VAL A-190
 None
 1.40A 5w4zA-4qszA:
undetectable		 5w4zA-4qszA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		6 / 12 ALA A -29
ALA A -33
GLY A-205
ALA A-183
PHE A-202
VAL A-190
 None
 1.42A 5w4zB-4qszA:
undetectable		 5w4zB-4qszA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		3 / 3 TYR A-216
ASN A-144
LEU A-258
 GLC  A 901 ( 3.8A)
None
None
 0.84A 6b58A-4qszA:
undetectable		 6b58A-4qszA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		5 / 11 PRO A-238
GLU A-241
PRO A-117
ALA A-208
PRO A-212
 None
 1.47A 6bm5A-4qszA:
undetectable		 6bm5A-4qszA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA
(Escherichia
coli;
Mus
musculus) 		4 / 4 LEU A 259
ASP A 202
PRO A 199
ARG A  21
 None
 1.20A 6fgdA-4qszA:
undetectable		 6fgdA-4qszA:
20.38