SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		4 / 8 MET A  25
ALA A  26
GLY A  23
ILE A  22
 None
 0.63A 2zm9A-4qt4A:
undetectable		 2zm9A-4qt4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		5 / 11 MET A  25
ALA A  26
ASN A  29
GLY A  23
ILE A  22
 None
 1.04A 2zmaA-4qt4A:
undetectable		 2zmaA-4qt4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		4 / 8 PRO A  63
ASN A  10
SER A 118
GLY A 115
 None
 0.91A 3lslA-4qt4A:
undetectable
3lslD-4qt4A:
undetectable		 3lslA-4qt4A:
22.54
3lslD-4qt4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		4 / 7 TYR A  92
VAL A  31
VAL A 167
ILE A   5
 None
 1.29A 3ms9B-4qt4A:
undetectable		 3ms9B-4qt4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		4 / 7 VAL A  90
ILE A 120
HIS A  20
LEU A  95
 None
 1.13A 4xo7B-4qt4A:
undetectable		 4xo7B-4qt4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4qt4 PEPTIDYL-TRNA
HYDROLASE
(Streptococcus
pyogenes) 		5 / 12 SER A  70
GLY A 115
GLY A   7
VAL A 167
ILE A 131
 None
 0.84A 5ec8A-4qt4A:
undetectable		 5ec8A-4qt4A:
21.25