SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 GLY B 113
SER B 137
ASP B 119
ASP B 117
 None
 0.90A 1m4iA-4qt8B:
undetectable		 1m4iA-4qt8B:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.23A 1q23B-4qt8B:
undetectable		 1q23B-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.20A 1q23C-4qt8B:
undetectable		 1q23C-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 10 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.21A 1q23E-4qt8B:
undetectable		 1q23E-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.18A 1q23F-4qt8B:
undetectable		 1q23F-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.19A 1q23H-4qt8B:
undetectable
1q23I-4qt8B:
undetectable		 1q23H-4qt8B:
13.64
1q23I-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.21A 1q23I-4qt8B:
undetectable		 1q23I-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 10 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.29A 1q23K-4qt8B:
undetectable		 1q23K-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 LEU B 510
PHE B 511
ALA B 512
LEU B  85
 None
 0.97A 1ukbA-4qt8B:
undetectable		 1ukbA-4qt8B:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 235
LEU B 398
ILE B 247
THR B 263
ILE B 218
 None
 1.14A 2jn3A-4qt8B:
undetectable		 2jn3A-4qt8B:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL B  72
LEU B  81
ALA B  92
GLY B  53
ALA B  51
 None
 1.09A 3ln1D-4qt8B:
undetectable		 3ln1D-4qt8B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
 None
 1.21A 3me6C-4qt8B:
undetectable		 3me6C-4qt8B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
 None
 1.26A 3me6D-4qt8B:
undetectable		 3me6D-4qt8B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 LEU B 262
ARG B 185
MET B  58
 None
 0.91A 4m11C-4qt8B:
undetectable		 4m11C-4qt8B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 ALA B  73
ALA B  57
GLY B  52
GLY B  53
ASP B 119
 None
 1.16A 4qwuK-4qt8B:
undetectable
4qwuL-4qt8B:
undetectable		 4qwuK-4qt8B:
15.89
4qwuL-4qt8B:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 ALA B  73
ALA B  57
GLY B  52
GLY B  53
ASP B 119
 None
 1.16A 4qwuY-4qt8B:
undetectable
4qwuZ-4qt8B:
undetectable		 4qwuY-4qt8B:
15.89
4qwuZ-4qt8B:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 VAL B 498
HIS B 463
VAL B 520
 None
 0.68A 5jmnC-4qt8B:
undetectable		 5jmnC-4qt8B:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 THR B 153
PRO B  83
ASP B  84
 None
 0.73A 5l8dB-4qt8B:
undetectable		 5l8dB-4qt8B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 THR B 153
PRO B  83
ASP B  84
 None
 0.73A 5mwuB-4qt8B:
undetectable		 5mwuB-4qt8B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLU B 475
LEU B 451
ALA B 462
ARG B 470
LEU B 483
 None
None
None
NAG  B 701 (-3.7A)
None
 1.26A 5nd4B-4qt8B:
undetectable		 5nd4B-4qt8B:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 THR B 263
HIS B 277
PHE B 400
TYR B 249
 None
 1.23A 5v4vA-4qt8B:
undetectable		 5v4vA-4qt8B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 THR B 263
HIS B 277
PHE B 400
TYR B 249
 None
 1.23A 5v4vB-4qt8B:
undetectable		 5v4vB-4qt8B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL B 461
THR B 454
LEU B 483
LEU B 443
VAL B 366
 None
 1.31A 6a93B-4qt8B:
undetectable		 6a93B-4qt8B:
20.12