SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 3V5  A 502 (-3.7A)
None
None
None
None
 1.41A 1gtnO-4qtfA:
undetectable
1gtnP-4qtfA:
undetectable		 1gtnO-4qtfA:
12.89
1gtnP-4qtfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 3V5  A 502 (-3.7A)
None
None
None
None
 1.41A 1gtnQ-4qtfA:
undetectable
1gtnR-4qtfA:
undetectable		 1gtnQ-4qtfA:
12.89
1gtnR-4qtfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 356
MET A 280
GLY A 281
THR A 287
GLY A 332
 None
None
None
None
3V5  A 502 (-3.3A)
 1.11A 1jr1A-4qtfA:
undetectable		 1jr1A-4qtfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
None
None
3V5  A 502 (-3.3A)
 0.75A 1jr1B-4qtfA:
undetectable		 1jr1B-4qtfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 137
THR A 138
ALA A 128
ALA A 130
VAL A  59
 None
 0.93A 2f16K-4qtfA:
undetectable
2f16L-4qtfA:
undetectable		 2f16K-4qtfA:
22.39
2f16L-4qtfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 137
THR A 138
ALA A 128
ALA A 130
VAL A  59
 None
 0.93A 2f16Y-4qtfA:
undetectable
2f16Z-4qtfA:
undetectable		 2f16Y-4qtfA:
22.39
2f16Z-4qtfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.21A 2po7B-4qtfA:
undetectable		 2po7B-4qtfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  75
TYR A 229
VAL A 101
VAL A  79
 None
 1.33A 2y05A-4qtfA:
undetectable
2y05B-4qtfA:
undetectable		 2y05A-4qtfA:
23.47
2y05B-4qtfA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 140
THR A 138
ASN A 127
 None
 0.88A 3v4tE-4qtfA:
undetectable		 3v4tE-4qtfA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.14A 4eb4D-4qtfA:
undetectable		 4eb4D-4qtfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
None
None
3V5  A 502 (-3.3A)
 0.69A 4fo4B-4qtfA:
undetectable		 4fo4B-4qtfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 374
ASP A 389
LEU A 391
GLY A 392
 None
 0.75A 4iqqC-4qtfA:
undetectable		 4iqqC-4qtfA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 386
ASP A 389
SER A 331
SER A 329
 None
 1.22A 4k7gB-4qtfA:
undetectable		 4k7gB-4qtfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		3 / 3 SER A  65
ASP A  76
ASP A 232
 MLD  A 501 (-4.7A)
None
None
 0.87A 4mwzA-4qtfA:
undetectable		 4mwzA-4qtfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 137
THR A 138
ALA A 128
ALA A 130
VAL A  59
 None
 0.91A 4qvyK-4qtfA:
undetectable
4qvyL-4qtfA:
undetectable		 4qvyK-4qtfA:
22.09
4qvyL-4qtfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 137
THR A 138
ALA A 128
ALA A 130
VAL A  59
 None
 0.91A 4qvyY-4qtfA:
undetectable
4qvyZ-4qtfA:
undetectable		 4qvyY-4qtfA:
22.09
4qvyZ-4qtfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.29A 4w5qA-4qtfA:
undetectable		 4w5qA-4qtfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.31A 4z4fA-4qtfA:
undetectable		 4z4fA-4qtfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.27A 4z4gA-4qtfA:
undetectable		 4z4gA-4qtfA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.24A 4z4hA-4qtfA:
undetectable		 4z4hA-4qtfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 367
ALA A 362
THR A 326
TYR A 366
 None
 1.24A 4z4iA-4qtfA:
undetectable		 4z4iA-4qtfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 SER A 351
THR A 278
THR A 380
THR A 287
 3V5  A 502 ( 3.7A)
None
None
None
 1.02A 5l4eA-4qtfA:
undetectable
5l4eB-4qtfA:
undetectable
5l4eC-4qtfA:
undetectable
5l4eD-4qtfA:
undetectable
5l4eE-4qtfA:
undetectable		 5l4eA-4qtfA:
22.81
5l4eB-4qtfA:
22.81
5l4eC-4qtfA:
22.81
5l4eD-4qtfA:
22.81
5l4eE-4qtfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.01A 5x66A-4qtfA:
undetectable
5x66B-4qtfA:
undetectable		 5x66A-4qtfA:
19.61
5x66B-4qtfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.01A 5x66C-4qtfA:
undetectable		 5x66C-4qtfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 332
VAL A 333
THR A 384
GLY A 383
GLY A 382
 3V5  A 502 (-3.3A)
3V5  A 502 ( 4.9A)
None
None
None
 1.22A 6brdB-4qtfA:
undetectable		 6brdB-4qtfA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 211
ARG A 209
ASP A 393
 None
 0.84A 6d8pA-4qtfA:
undetectable		 6d8pA-4qtfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 374
LEU A 391
GLY A 392
ASN A 395
ILE A 328
 None
 1.06A 6qxsB-4qtfA:
undetectable		 6qxsB-4qtfA:
21.22