SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4qti ANTI-UPAR ANTIBODY,
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 126
PRO H 156
THR H 125
PRO H 127
 None
 1.35A 1dsdC-4qtiH:
undetectable		 1dsdC-4qtiH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4qti ANTI-UPAR ANTIBODY,
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 126
PRO H 156
THR H 125
PRO H 127
 None
 1.35A 1dsdC-4qtiH:
undetectable		 1dsdC-4qtiH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 THR U  26
SER U  65
THR U  67
VAL U  69
 None
 0.58A 1ictD-4qtiU:
undetectable		 1ictD-4qtiU:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 8 TYR U 195
LEU U 212
GLY U 191
ASP U 214
 None
 1.02A 1rmtC-4qtiU:
undetectable		 1rmtC-4qtiU:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4qti ANTI-UPAR ANTIBODY,
HEAVY CHAIN
(Mus
musculus) 		5 / 12 ASP H  90
PHE H  64
MET H  81
PHE H  70
GLY H  66
 None
 1.30A 2fqyA-4qtiH:
undetectable		 2fqyA-4qtiH:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 VAL U 238
TYR U 236
ILE U 130
ASP U 163
 None
 1.05A 2x45B-4qtiU:
undetectable		 2x45B-4qtiU:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 VAL U 238
TYR U 236
ILE U 130
ASP U 163
 None
 1.02A 2x45C-4qtiU:
undetectable		 2x45C-4qtiU:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 VAL U 238
TYR U 236
ILE U 130
ASP U 163
 None
 1.10A 3bu1A-4qtiU:
undetectable		 3bu1A-4qtiU:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qti ANTI-UPAR ANTIBODY,
HEAVY CHAIN
(Mus
musculus) 		3 / 3 VAL H 202
VAL H 172
SER H 170
 None
 0.73A 3n8xB-4qtiH:
undetectable		 3n8xB-4qtiH:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 8 THR U  26
SER U  65
THR U  67
VAL U  69
 None
 0.52A 4ik7B-4qtiU:
undetectable		 4ik7B-4qtiU:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4qti ANTI-UPAR ANTIBODY,
HEAVY CHAIN
(Mus
musculus) 		3 / 3 ASP H  99
TYR H 108
TRP H  33
 None
 1.22A 4p7nA-4qtiH:
undetectable		 4p7nA-4qtiH:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 4 THR U  51
LEU U 150
HIS U 251
GLY U 152
 None
 1.06A 5gwyA-4qtiU:
undetectable		 5gwyA-4qtiU:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU U 184
PHE U 165
ILE U 130
ASN U 162
 None
 0.89A 5n5dA-4qtiU:
undetectable		 5n5dA-4qtiU:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens) 		4 / 7 ARG U 239
LEU U 252
PHE U 256
THR U 164
 None
 1.03A 5vc0A-4qtiU:
undetectable		 5vc0A-4qtiU:
19.92