SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 8 PRO C 211
GLU C 213
GLU C 168
ARG C 105
 None
 1.21A 1dtlA-4qtsC:
undetectable		 1dtlA-4qtsC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  50
GLY A  46
LYS A 220
TYR A  41
 None
 1.06A 1gtiC-4qtsA:
undetectable		 1gtiC-4qtsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  50
GLY A  46
LYS A 220
TYR A  41
 None
 1.06A 1gtiD-4qtsA:
undetectable		 1gtiD-4qtsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  50
GLY A  46
LYS A 220
TYR A  41
 None
 1.06A 1gtiF-4qtsA:
undetectable		 1gtiF-4qtsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 107
ILE A 135
ILE A  72
GLU A 141
 None
 0.94A 1oniD-4qtsA:
undetectable
1oniF-4qtsA:
undetectable		 1oniD-4qtsA:
16.47
1oniF-4qtsA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE C 163
SER C  53
PHE C  92
LEU C 231
 None
 0.89A 1qcaA-4qtsC:
undetectable		 1qcaA-4qtsC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 PRO A 280
GLY A 278
THR A 358
GLY A 360
 None
 0.83A 1usqA-4qtsA:
undetectable		 1usqA-4qtsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE C 205
ILE C 174
VAL C 161
PHE C 159
ILE C  59
 None
 1.03A 3b2rA-4qtsC:
undetectable		 3b2rA-4qtsC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE C  48
TYR C 112
ILE C  41
HIS C  23
 None
 1.15A 3eteA-4qtsC:
undetectable
3eteE-4qtsC:
undetectable		 3eteA-4qtsC:
19.84
3eteE-4qtsC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE C  48
TYR C 112
ILE C  41
HIS C  23
 None
 1.15A 3eteB-4qtsC:
undetectable
3eteC-4qtsC:
undetectable		 3eteB-4qtsC:
19.84
3eteC-4qtsC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE C  41
HIS C  23
ILE C  48
TYR C 112
 None
 1.15A 3eteD-4qtsC:
undetectable
3eteF-4qtsC:
undetectable		 3eteD-4qtsC:
19.84
3eteF-4qtsC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
PHE A 206
SER A  63
ILE A  37
ALA A  36
 None
 1.12A 3mdtB-4qtsA:
undetectable		 3mdtB-4qtsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.85A 3nbqC-4qtsA:
undetectable		 3nbqC-4qtsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY C  52
ASP C 110
ARG C 109
GLN C 114
 None
 1.36A 3qx3B-4qtsC:
undetectable		 3qx3B-4qtsC:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  83
GLN A 129
PHE A 367
 None
 0.80A 3rv5A-4qtsA:
undetectable		 3rv5A-4qtsA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		4 / 4 VAL C 108
PHE C 159
PHE C 157
VAL C  40
 None
 1.14A 3rv5C-4qtsC:
undetectable
3rv5D-4qtsC:
undetectable		 3rv5C-4qtsC:
11.85
3rv5D-4qtsC:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  34
TYR A  41
LEU A  65
 None
 0.73A 3sueB-4qtsA:
undetectable		 3sueB-4qtsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A 206
ILE A  69
LEU A  74
LYS A  68
 None
 1.25A 3sueC-4qtsA:
undetectable		 3sueC-4qtsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  50
VAL A  38
VAL A 330
ASP A 332
 None
 1.08A 4ek1A-4qtsA:
undetectable		 4ek1A-4qtsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A  82
ASN A 120
ILE A 122
TRP A 118
 None
 1.23A 4ii8A-4qtsA:
undetectable		 4ii8A-4qtsA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A 229
GLU A 245
GLU C 160
GLU C  13
 None
 1.29A 4mi4A-4qtsA:
undetectable		 4mi4A-4qtsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 229
GLU A 245
GLU C 160
GLU C  13
 None
 1.14A 4mj8C-4qtsA:
undetectable		 4mj8C-4qtsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.80A 4txnA-4qtsA:
undetectable		 4txnA-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.79A 4txnB-4qtsA:
undetectable		 4txnB-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.81A 4txnC-4qtsA:
undetectable		 4txnC-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.81A 4txnD-4qtsA:
undetectable		 4txnD-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  31
SER A  30
ILE A 279
PRO A 280
ILE A 313
 None
 1.36A 4uroA-4qtsA:
undetectable		 4uroA-4qtsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  31
SER A  30
ILE A 279
PRO A 280
ILE A 313
 None
 1.36A 4uroD-4qtsA:
undetectable		 4uroD-4qtsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 8 PRO A  76
MET A 273
LEU A  74
LEU A  66
 None
 1.05A 5dzkF-4qtsA:
undetectable
5dzkT-4qtsA:
undetectable		 5dzkF-4qtsA:
20.10
5dzkT-4qtsA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE C  59
VAL C 161
GLU C 185
LEU C 234
ILE C 178
 None
 1.46A 5mzpA-4qtsC:
undetectable		 5mzpA-4qtsC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  50
VAL A  38
VAL A 330
ASP A 332
 None
 1.05A 5wk9A-4qtsA:
undetectable		 5wk9A-4qtsA:
20.56