SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_B_9CRB165_2 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	4qu2	JMJC DOMAIN-CONTAINING PROTEIN 7 (Mus musculus)	4 / 8	LEU A 168 VAL A 288 VAL A 189 TYR A 71	None	0.83A	1epbB-4qu2A: undetectable	1epbB-4qu2A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_D_BEZD1221_0 (PEROXIREDOXIN 6)	4qu2	JMJC DOMAIN-CONTAINING PROTEIN 7 (Mus musculus)	4 / 8	VAL A 29 PRO A 30 PRO A 26 VAL A 25	None	0.95A	2v32C-4qu2A: undetectable 2v32D-4qu2A: undetectable	2v32C-4qu2A: 21.98 2v32D-4qu2A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR)	4qu2	JMJC DOMAIN-CONTAINING PROTEIN 7 (Mus musculus)	6 / 10	TYR A 127 THR A 175 HIS A 178 ASP A 180 HIS A 277 TRP A 291	AKG A 502 (-4.5A) AKG A 502 (-3.2A) NI A 501 ( 3.6A) NI A 501 (-3.7A) NI A 501 ( 3.8A) AKG A 502 (-4.1A)	0.92A	3kcxA-4qu2A: 21.3	3kcxA-4qu2A: 25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR)	4qu2	JMJC DOMAIN-CONTAINING PROTEIN 7 (Mus musculus)	6 / 10	TYR A 127 THR A 175 HIS A 178 ASP A 180 LYS A 193 HIS A 277	AKG A 502 (-4.5A) AKG A 502 (-3.2A) NI A 501 ( 3.6A) NI A 501 (-3.7A) AKG A 502 (-3.8A) NI A 501 ( 3.8A)	0.73A	3kcxA-4qu2A: 21.3	3kcxA-4qu2A: 25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMD_A_YMZA3801_1 (60S RIBOSOMAL PROTEIN L28 28S RIBOSOMAL RNA 60S RIBOSOMAL PROTEIN L4)	4qu2	JMJC DOMAIN-CONTAINING PROTEIN 7 (Mus musculus)	4 / 6	ASN A 24 ALA A 20 PRO A 199 VAL A 25	None	1.02A	5umd2-4qu2A: undetectable 5umdF-4qu2A: undetectable	5umd2-4qu2A: 11.73 5umdF-4qu2A: 17.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EPB_B_9CRB165_2","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","4qu2","JMJC DOMAIN-CONTAINING PROTEIN 7","Mus musculus",4,"LEU A 168;VAL A 288;VAL A 189;TYR A  71","None","0.83A","1epbB-4qu2A:undetectable","1epbB-4qu2A:20.13"],["2V32_D_BEZD1221_0","PEROXIREDOXIN 6","4qu2","JMJC DOMAIN-CONTAINING PROTEIN 7","Mus musculus",4,"VAL A  29;PRO A  30;PRO A  26;VAL A  25","None","0.95A","2v32C-4qu2A:undetectable;2v32D-4qu2A:undetectable","2v32C-4qu2A:21.98;2v32D-4qu2A:21.98"],["3KCX_A_CQLA1_0","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","4qu2","JMJC DOMAIN-CONTAINING PROTEIN 7","Mus musculus",6,"TYR A 127;THR A 175;HIS A 178;ASP A 180;HIS A 277;TRP A 291","AKG A 502 (-4.5A);AKG A 502 (-3.2A); NI A 501 ( 3.6A); NI A 501 (-3.7A); NI A 501 ( 3.8A);AKG A 502 (-4.1A)","0.92A","3kcxA-4qu2A:21.3","3kcxA-4qu2A:25.28"],["3KCX_A_CQLA1_0","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","4qu2","JMJC DOMAIN-CONTAINING PROTEIN 7","Mus musculus",6,"TYR A 127;THR A 175;HIS A 178;ASP A 180;LYS A 193;HIS A 277","AKG A 502 (-4.5A);AKG A 502 (-3.2A); NI A 501 ( 3.6A); NI A 501 (-3.7A);AKG A 502 (-3.8A); NI A 501 ( 3.8A)","0.73A","3kcxA-4qu2A:21.3","3kcxA-4qu2A:25.28"],["5UMD_A_YMZA3801_1","60S RIBOSOMAL PROTEIN L28;28S RIBOSOMAL RNA;60S RIBOSOMAL PROTEIN L4","4qu2","JMJC DOMAIN-CONTAINING PROTEIN 7","Mus musculus",4,"ASN A  24;ALA A  20;PRO A 199;VAL A  25","None","1.02A","5umd2-4qu2A:undetectable;5umdF-4qu2A:undetectable","5umd2-4qu2A:11.73;5umdF-4qu2A:17.77"]]