SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4quk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.27A 1a52A-4qukA:
undetectable		 1a52A-4qukA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.30A 1a52B-4qukA:
undetectable		 1a52B-4qukA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		4 / 6 ASP A 233
THR A 305
PRO A 306
SER A 310
 None
 0.80A 1n4fA-4qukA:
undetectable		 1n4fA-4qukA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.30A 1pcgA-4qukA:
undetectable		 1pcgA-4qukA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.30A 1pcgB-4qukA:
undetectable		 1pcgB-4qukA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 172
ILE A 102
LEU A 171
PRO A 104
LEU A 101
 None
 1.04A 1yi4A-4qukA:
undetectable		 1yi4A-4qukA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.34A 3uudB-4qukA:
undetectable		 3uudB-4qukA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		4 / 5 GLY A  71
THR A  13
VAL A  76
ASP A  74
 None
 0.88A 4eohA-4qukA:
3.0		 4eohA-4qukA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.93A 4k8cA-4qukA:
6.6		 4k8cA-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.93A 4kahA-4qukA:
3.9		 4kahA-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.92A 4kahB-4qukA:
6.1		 4kahB-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.95A 4kanA-4qukA:
4.2		 4kanA-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.92A 4kanB-4qukA:
6.1		 4kanB-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.92A 4kbeA-4qukA:
6.7		 4kbeA-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.92A 4kbeB-4qukA:
6.7		 4kbeB-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		4 / 7 PRO A 192
SER A 130
VAL A 231
MET A 194
 None
 1.15A 4klrA-4qukA:
2.4		 4klrA-4qukA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		4 / 7 PRO A 192
SER A 130
VAL A 231
MET A 194
 None
 1.13A 4kmmA-4qukA:
2.8		 4kmmA-4qukA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.92A 4lbgA-4qukA:
6.2		 4lbgA-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		3 / 3 SER A 261
TYR A 286
PRO A 277
 None
 0.93A 4lbgB-4qukA:
6.1		 4lbgB-4qukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.36A 5dxeB-4qukA:
undetectable		 5dxeB-4qukA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 12 THR A 170
LEU A 127
ALA A 105
ILE A 102
THR A  13
 None
 1.46A 5ewjC-4qukA:
3.9
5ewjD-4qukA:
2.6		 5ewjC-4qukA:
20.56
5ewjD-4qukA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.32A 5hyrA-4qukA:
undetectable		 5hyrA-4qukA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 11 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.34A 5hyrB-4qukA:
undetectable		 5hyrB-4qukA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 12 VAL A  34
LEU A  28
VAL A  38
GLY A  14
ALA A  15
 None
 1.07A 5jw1A-4qukA:
undetectable		 5jw1A-4qukA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 9 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.37A 5wgdA-4qukA:
undetectable		 5wgdA-4qukA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4quk DIHYDROFLAVONOL-4-RE
DUCTASE
(Medicago
truncatula) 		5 / 10 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.33A 5wgqB-4qukA:
undetectable		 5wgqB-4qukA:
11.76