SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4quv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 6 TRP A  25
LEU A  28
LEU A  32
PRO A  33
 None
 1.26A 1hz4A-4quvA:
undetectable		 1hz4A-4quvA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 6 ASN A 305
TYR A 241
GLY A 236
TRP A 209
 None
 1.47A 1mxdA-4quvA:
undetectable		 1mxdA-4quvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 296
VAL A 295
PRO A 294
 None
 1.00A 1rg1A-4quvA:
undetectable		 1rg1A-4quvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 6 LEU A 404
ASP A 400
TRP A 411
ARG A 356
 None
 1.00A 2rlfB-4quvA:
undetectable
2rlfC-4quvA:
undetectable		 2rlfB-4quvA:
6.73
2rlfC-4quvA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 7 TYR A  38
TRP A  63
TYR A  46
ARG A  61
 None
 1.29A 3wipA-4quvA:
undetectable
3wipB-4quvA:
undetectable		 3wipA-4quvA:
18.06
3wipB-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 8 ARG A  61
TYR A  38
TRP A  63
TYR A  46
 None
 1.30A 3wipA-4quvA:
undetectable
3wipE-4quvA:
undetectable		 3wipA-4quvA:
18.06
3wipE-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 7 TYR A  38
TRP A  63
TYR A  46
ARG A  61
 None
 1.27A 3wipF-4quvA:
undetectable
3wipG-4quvA:
undetectable		 3wipF-4quvA:
18.06
3wipG-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 8 TYR A  38
TRP A  63
TYR A  46
ARG A  61
 None
 1.28A 3wipG-4quvA:
undetectable
3wipH-4quvA:
undetectable		 3wipG-4quvA:
18.06
3wipH-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 265
VAL A 155
TRP A 269
 None
 1.21A 3zq8A-4quvA:
undetectable
3zq8B-4quvA:
undetectable		 3zq8A-4quvA:
3.41
3zq8B-4quvA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		5 / 12 LEU A 275
ASP A 363
PHE A 388
LEU A 392
HIS A 384
 None
 1.15A 5nn8A-4quvA:
undetectable		 5nn8A-4quvA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		5 / 12 TRP A 370
ASP A 363
PHE A 388
LEU A 392
HIS A 384
 None
 1.30A 5nn8A-4quvA:
undetectable		 5nn8A-4quvA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4quv DELTA(14)-STEROL
REDUCTASE
(Methylomicrobium
alcaliphilum) 		4 / 5 LEU A 214
LEU A 210
MET A 231
TYR A 221
 None
 1.30A 5uc3A-4quvA:
undetectable		 5uc3A-4quvA:
12.59