SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 LEU A 242
LEU A 273
SER A 341
SER A 339
 None
 0.91A 1dvxA-4qvgA:
undetectable		 1dvxA-4qvgA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 10 GLY A 178
ASN A 184
ASP A 201
ASP A 228
TRP A 250
 None
 0.71A 1fpqA-4qvgA:
21.7		 1fpqA-4qvgA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 10 GLY A 178
ASP A 201
ASP A 228
ALA A 244
TRP A 250
 None
 1.11A 1fpqA-4qvgA:
21.7		 1fpqA-4qvgA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 THR A  63
LEU A  67
GLY A  78
LEU A  33
 None
 0.90A 1gtiB-4qvgA:
undetectable		 1gtiB-4qvgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 THR A  63
LEU A  67
GLY A  78
LEU A  33
 None
 0.90A 1gtiD-4qvgA:
undetectable		 1gtiD-4qvgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 THR A  63
LEU A  67
GLY A  78
LEU A  33
 None
 0.88A 1gtiE-4qvgA:
undetectable		 1gtiE-4qvgA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 GLY A 178
GLY A 179
GLY A 180
ASP A 228
TRP A 250
 None
 0.61A 1qzzA-4qvgA:
21.5		 1qzzA-4qvgA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 GLY A 178
GLY A 179
GLY A 180
ASP A 228
TRP A 250
 None
 0.55A 1xdsA-4qvgA:
7.8		 1xdsA-4qvgA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 GLY A 178
GLY A 179
GLY A 180
ASP A 228
TRP A 250
 None
 0.51A 1xdsB-4qvgA:
23.1		 1xdsB-4qvgA:
30.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		3 / 3 GLN A 156
HIS A 152
ARG A 149
 None
 0.83A 1zlqA-4qvgA:
undetectable		 1zlqA-4qvgA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 8 HIS A 238
ALA A 265
LEU A 200
HIS A 225
 None
 0.87A 2it4A-4qvgA:
undetectable		 2it4A-4qvgA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 VAL A 338
TRP A 309
ARG A 308
THR A 305
 None
 1.22A 2x2iA-4qvgA:
undetectable		 2x2iA-4qvgA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 VAL A 177
GLY A 178
GLY A 180
ALA A 244
LEU A 258
 None
 1.09A 3dh0A-4qvgA:
17.6		 3dh0A-4qvgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 GLU A 267
PRO A 268
ARG A 173
HIS A 238
 None
 1.27A 3ltwA-4qvgA:
undetectable		 3ltwA-4qvgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 11 GLY A  24
THR A  62
LEU A  59
ARG A  52
LEU A  48
 None
 1.33A 3ndvA-4qvgA:
undetectable
3ndvB-4qvgA:
undetectable		 3ndvA-4qvgA:
22.74
3ndvB-4qvgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 11 GLY A  24
THR A  62
LEU A  59
ARG A  52
LEU A  48
 None
 1.38A 3ndvC-4qvgA:
undetectable
3ndvD-4qvgA:
undetectable		 3ndvC-4qvgA:
22.74
3ndvD-4qvgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 GLY A  88
TRP A  90
GLU A  31
ARG A  94
 None
 1.29A 4bqfA-4qvgA:
undetectable		 4bqfA-4qvgA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 ASP A 176
GLY A 178
ASP A 201
ASP A 228
TRP A 250
 None
 0.50A 4pghB-4qvgA:
28.0		 4pghB-4qvgA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 11 SER A 155
GLY A 178
ASP A 201
ASP A 228
TRP A 250
 None
 1.30A 4pghC-4qvgA:
29.3		 4pghC-4qvgA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 GLY A 178
GLY A 179
ASP A 201
ASP A 228
PHE A 230
 None
 1.07A 4pghD-4qvgA:
28.4		 4pghD-4qvgA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 GLY A 178
GLY A 179
ASP A 201
PHE A 230
TRP A 250
 None
 0.63A 4pghD-4qvgA:
28.4		 4pghD-4qvgA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 ALA A 209
THR A 212
ALA A 214
THR A 224
 None
 1.02A 4qw0K-4qvgA:
undetectable		 4qw0K-4qvgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 7 ALA A 209
THR A 212
ALA A 214
THR A 224
 None
 1.02A 4qw0Y-4qvgA:
undetectable		 4qw0Y-4qvgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 ARG A  76
GLY A  78
THR A  71
ARG A  86
 None
 1.07A 5btaA-4qvgA:
2.8
5btaB-4qvgA:
undetectable
5btaC-4qvgA:
2.8		 5btaA-4qvgA:
21.39
5btaB-4qvgA:
24.19
5btaC-4qvgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 ARG A  86
ARG A  76
GLY A  78
THR A  71
 None
 1.08A 5btcA-4qvgA:
2.8
5btcC-4qvgA:
2.7
5btcD-4qvgA:
undetectable		 5btcA-4qvgA:
21.39
5btcC-4qvgA:
21.39
5btcD-4qvgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 6 ARG A  76
GLY A  78
THR A  71
ARG A  86
 None
 1.05A 5btcA-4qvgA:
2.9
5btcB-4qvgA:
undetectable
5btcC-4qvgA:
2.8		 5btcA-4qvgA:
21.39
5btcB-4qvgA:
24.19
5btcC-4qvgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		4 / 4 ASP A 176
GLY A 180
ASP A 201
ASP A 228
 None
 1.05A 5e72A-4qvgA:
15.0		 5e72A-4qvgA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 12 TYR A 134
ALA A 139
ALA A 138
GLY A 128
THR A 129
 None
 1.05A 5igjA-4qvgA:
undetectable		 5igjA-4qvgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4qvg SIBL
(Streptosporangiu
m
sibiricum) 		5 / 11 SER A 155
GLY A 178
GLY A 180
ASP A 201
ASP A 228
 None
 1.07A 6i5zD-4qvgA:
28.4		 6i5zD-4qvgA:
23.13