SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 8 MET A 513
GLU A 552
GLU A 505
ASP A 508
 None
 1.22A 1dtlA-4qvhA:
undetectable		 1dtlA-4qvhA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
 None
 0.95A 1e06A-4qvhA:
undetectable		 1e06A-4qvhA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 9 ILE A 444
VAL A 473
GLY A 460
ALA A 430
LEU A 434
 None
 0.87A 1e7bA-4qvhA:
undetectable		 1e7bA-4qvhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 6 VAL A 473
GLY A 460
ALA A 430
LEU A 434
 None
 0.75A 1e7bB-4qvhA:
undetectable		 1e7bB-4qvhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 GLU A 388
LEU A  44
LEU A 437
ARG A 475
ILE A 432
 None
 1.09A 1errA-4qvhA:
undetectable		 1errA-4qvhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 4 ALA A 365
VAL A 344
ALA A 343
HIS A 428
 None
 1.22A 1q23K-4qvhA:
undetectable		 1q23K-4qvhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 10 GLY A 460
VAL A 482
GLY A 483
VAL A 473
HIS A 464
 None
None
None
None
COA  A 602 (-3.6A)
 1.22A 1v3qE-4qvhA:
undetectable		 1v3qE-4qvhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 2dcfA-4qvhA:
undetectable		 2dcfA-4qvhA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.08A 2h42C-4qvhA:
undetectable		 2h42C-4qvhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 10 VAL A 381
VAL A 378
VAL A 482
ILE A 596
VAL A 597
 None
 1.15A 2qboA-4qvhA:
undetectable		 2qboA-4qvhA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 LEU A 382
PRO A 383
LEU A 390
 None
 0.46A 2qd5B-4qvhA:
undetectable		 2qd5B-4qvhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 ALA A 265
LEU A 281
PHE A 280
VAL A 294
GLY A  17
 None
 1.09A 2ve3A-4qvhA:
undetectable		 2ve3A-4qvhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.29A 2zmaA-4qvhA:
undetectable		 2zmaA-4qvhA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-4qvhA:
undetectable		 3bjwC-4qvhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.88A 3bjwA-4qvhA:
undetectable		 3bjwA-4qvhA:
13.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 MAL  A 601 ( 4.6A)
MAL  A 601 (-4.3A)
MAL  A 601 (-3.6A)
MAL  A 601 (-3.9A)
MAL  A 601 ( 4.4A)
MAL  A 601 (-3.6A)
 0.24A 3jyrA-4qvhA:
62.0		 3jyrA-4qvhA:
61.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 1.07A 3mg0V-4qvhA:
undetectable
3mg0W-4qvhA:
undetectable		 3mg0V-4qvhA:
18.30
3mg0W-4qvhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4qvhA:
undetectable		 3n8yB-4qvhA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 601 (-2.8A)
None
 0.85A 3tbgB-4qvhA:
undetectable		 3tbgB-4qvhA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 601 (-2.8A)
None
 0.83A 3tbgD-4qvhA:
undetectable		 3tbgD-4qvhA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 10 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 3vwpA-4qvhA:
undetectable		 3vwpA-4qvhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.36A 3vwqA-4qvhA:
undetectable		 3vwqA-4qvhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 5 GLU A 309
ASP A 315
ASP A 288
ASN A 295
 None
None
None
GOL  A 607 (-3.4A)
 1.36A 3vywD-4qvhA:
undetectable		 3vywD-4qvhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 7 LYS A 527
LEU A 523
THR A 530
ALA A 526
THR A 594
 None
None
COA  A 602 ( 4.4A)
None
None
 1.45A 4ik7A-4qvhA:
undetectable		 4ik7A-4qvhA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 LYS A 527
LEU A 523
ALA A 526
 None
 0.64A 4ikiA-4qvhA:
undetectable		 4ikiA-4qvhA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 ILE A 267
ALA A 270
PHE A  48
THR A 376
GLY A  55
 None
 1.07A 4ls7A-4qvhA:
undetectable
4ls7B-4qvhA:
undetectable		 4ls7A-4qvhA:
22.15
4ls7B-4qvhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 5 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 601 (-3.1A)
 1.00A 4n48A-4qvhA:
undetectable		 4n48A-4qvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 8 PHE A 423
GLU A 528
ASP A 485
TYR A 468
 None
COA  A 602 (-2.8A)
COA  A 602 ( 2.7A)
None
 1.43A 4qb9D-4qvhA:
undetectable		 4qb9D-4qvhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 7 GLU A 552
ILE A 549
LEU A 492
ILE A 522
 None
 0.84A 4xumA-4qvhA:
undetectable		 4xumA-4qvhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.20A 5e4dB-4qvhA:
undetectable		 5e4dB-4qvhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 PRO A 443
ARG A 431
GLU A 407
 None
 1.00A 5j6hA-4qvhA:
undetectable		 5j6hA-4qvhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		4 / 7 THR A 373
LEU A 462
VAL A 482
GLU A 487
 GOL  A 605 (-4.9A)
COA  A 602 (-3.8A)
None
MG  A 603 ( 3.3A)
 0.97A 5tudA-4qvhA:
undetectable		 5tudA-4qvhA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.44A 5w4zA-4qvhA:
undetectable		 5w4zA-4qvhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.47A 5w4zB-4qvhA:
undetectable		 5w4zB-4qvhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MAL  A 601 (-3.9A)
None
None
 0.82A 6b58A-4qvhA:
undetectable		 6b58A-4qvhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.44A 6bm5A-4qvhA:
undetectable		 6bm5A-4qvhA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 12 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 0.98A 6hwdH-4qvhA:
undetectable
6hwdI-4qvhA:
undetectable		 6hwdH-4qvhA:
8.36
6hwdI-4qvhA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA
(Escherichia
coli;
Mycobacterium
tuberculosis) 		5 / 11 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 0.98A 6hwdV-4qvhA:
undetectable		 6hwdV-4qvhA:
8.36