SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4qvj VP1
(Norwalk
virus) 		4 / 8 PHE A 493
ALA A 502
PHE A 227
VAL A 225
 None
 0.81A 1epbB-4qvjA:
undetectable		 1epbB-4qvjA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4qvj VP1
(Norwalk
virus) 		4 / 7 PRO A 430
THR A 385
PRO A 386
GLY A 387
 None
 0.98A 2vl2B-4qvjA:
undetectable		 2vl2B-4qvjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qvj VP1
(Norwalk
virus) 		3 / 3 PRO A 352
LEU A 353
GLN A 349
 None
 0.41A 3hznG-4qvjA:
undetectable
3hznH-4qvjA:
undetectable		 3hznG-4qvjA:
22.06
3hznH-4qvjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4qvj VP1
(Norwalk
virus) 		4 / 5 ARG A 370
ARG A 287
GLY A 340
GLU A 337
 None
 1.08A 3k9fA-4qvjA:
undetectable
3k9fB-4qvjA:
undetectable
3k9fC-4qvjA:
undetectable		 3k9fA-4qvjA:
19.64
3k9fB-4qvjA:
19.64
3k9fC-4qvjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4qvj VP1
(Norwalk
virus) 		4 / 6 ARG A 370
ARG A 287
GLY A 340
GLU A 337
 None
 1.08A 3k9fA-4qvjA:
undetectable
3k9fB-4qvjA:
undetectable
3k9fD-4qvjA:
undetectable		 3k9fA-4qvjA:
19.64
3k9fB-4qvjA:
19.64
3k9fD-4qvjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4qvj VP1
(Norwalk
virus) 		4 / 7 HIS A 515
PRO A 516
VAL A 233
GLU A 235
 None
 1.00A 4hvrA-4qvjA:
undetectable		 4hvrA-4qvjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4qvj VP1
(Norwalk
virus) 		5 / 12 LEU A 497
PHE A 227
TRP A 555
ALA A 506
ASP A 553
 None
 1.39A 4j7xA-4qvjA:
undetectable		 4j7xA-4qvjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4qvj VP1
(Norwalk
virus) 		4 / 5 GLU A 530
MET A 533
LEU A 511
HIS A 496
 None
 1.31A 4xi3B-4qvjA:
undetectable		 4xi3B-4qvjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4qvj VP1
(Norwalk
virus) 		4 / 7 ARG A 520
ASP A 517
GLY A 548
GLU A 235
 None
 0.89A 4z53A-4qvjA:
undetectable
4z53B-4qvjA:
undetectable		 4z53A-4qvjA:
18.47
4z53B-4qvjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4qvj VP1
(Norwalk
virus) 		5 / 12 LEU A 489
TRP A 555
PHE A 227
PHE A 552
LEU A 497
 None
 1.44A 6a93A-4qvjA:
undetectable		 6a93A-4qvjA:
20.43