SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 6 LEU B 496
LEU B 499
SER B 502
THR B 454
 None
 0.99A 1ictB-4qx8B:
undetectable		 1ictB-4qx8B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		3 / 3 TRP A 221
TYR A 199
LEU A 201
 None
 1.08A 1kxhA-4qx8A:
undetectable		 1kxhA-4qx8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 12 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.36A 2g70B-4qx8A:
undetectable		 2g70B-4qx8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 12 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.38A 2g72A-4qx8A:
undetectable		 2g72A-4qx8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 7 LEU A 270
PHE A  78
PHE A 276
ILE A 268
PHE A  56
 None
 1.17A 2opxA-4qx8A:
undetectable		 2opxA-4qx8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		3 / 3 SER A 250
HIS A 239
ASP A 264
 None
 0.78A 2oxtA-4qx8A:
undetectable		 2oxtA-4qx8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 6 ASP A 214
HIS A 284
TYR A 222
ASN A 142
 NI  A 601 ( 2.5A)
NI  A 601 ( 3.4A)
None
AKG  A 602 (-3.8A)
 1.08A 2zs9A-4qx8A:
undetectable		 2zs9A-4qx8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 6 LEU B 496
LEU B 499
SER B 502
THR B 454
 None
 1.07A 3cfqA-4qx8B:
undetectable		 3cfqA-4qx8B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 12 VAL A 294
SER A 149
ILE A  86
VAL A 169
TYR A 193
 None
 1.15A 3g8iA-4qx8A:
undetectable		 3g8iA-4qx8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		7 / 10 LEU A 201
THR A 209
HIS A 212
ASP A 214
LYS A 229
ILE A 278
HIS A 284
 None
AKG  A 602 (-3.4A)
NI  A 601 ( 3.2A)
NI  A 601 ( 2.5A)
AKG  A 602 (-2.9A)
None
NI  A 601 ( 3.4A)
 0.91A 3kcxA-4qx8A:
15.4		 3kcxA-4qx8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 6 GLU A 364
TRP B 516
PRO A 174
ARG A 175
 None
 1.31A 3oxvA-4qx8A:
undetectable		 3oxvA-4qx8A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 12 ILE A  86
GLY A  85
THR A 275
THR A 162
ASP A 164
 None
 1.02A 4kadA-4qx8A:
undetectable		 4kadA-4qx8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		5 / 11 GLY A 273
ILE A 268
THR A 288
PRO A 289
THR A 290
 None
 0.78A 4l1aA-4qx8A:
undetectable		 4l1aA-4qx8A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 4 GLN A 308
THR A 218
GLU A 315
LEU A 241
 None
 1.49A 5m66A-4qx8A:
undetectable		 5m66A-4qx8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 5 VAL A 320
ARG A 325
GLY A 216
TYR A 312
 None
 1.35A 5x80A-4qx8A:
undetectable
5x80B-4qx8A:
undetectable		 5x80A-4qx8A:
18.51
5x80B-4qx8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A
(Mus
musculus) 		4 / 5 GLY A 216
TYR A 312
VAL A 320
ARG A 325
 None
 1.41A 5x80C-4qx8A:
undetectable
5x80D-4qx8A:
undetectable		 5x80C-4qx8A:
18.51
5x80D-4qx8A:
18.51