SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1
(Mus
musculus) 		5 / 12 LEU B 320
LEU B 370
LEU B 371
LEU B 326
LEU B 363
 None
 1.17A 1sqnB-4qxaB:
undetectable		 1sqnB-4qxaB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		5 / 12 THR A  39
GLY A  19
GLY A  17
GLY A  65
ASP A 127
 MG  A 302 ( 3.2A)
GTP  A 301 (-3.2A)
GTP  A 301 (-3.3A)
GTP  A 301 (-3.3A)
GTP  A 301 (-2.9A)
 0.96A 2b25A-4qxaA:
undetectable		 2b25A-4qxaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1
(Mus
musculus) 		4 / 8 PHE B 353
LEU B 278
LEU B 340
LEU B 326
 None
 0.74A 2bfpA-4qxaB:
undetectable		 2bfpA-4qxaB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1
(Mus
musculus) 		4 / 8 PHE B 353
LEU B 278
LEU B 340
LEU B 326
 None
 0.75A 2bfpD-4qxaB:
undetectable		 2bfpD-4qxaB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		5 / 9 LEU A  85
LEU A  84
LEU A  13
ILE A  11
PHE A 105
 None
 1.21A 2f7aB-4qxaA:
undetectable		 2f7aB-4qxaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1
(Mus
musculus) 		5 / 12 ILE B 318
ILE B 323
PHE B 419
LEU B 363
LEU B 280
 None
 1.17A 3em0B-4qxaB:
undetectable		 3em0B-4qxaB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		5 / 12 THR A 126
THR A 153
THR A 159
ILE A 121
LEU A  23
 None
 1.02A 3gwxA-4qxaA:
undetectable		 3gwxA-4qxaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		4 / 7 ILE A 172
ILE A  10
LEU A  49
VAL A  51
 None
 0.85A 3ua5B-4qxaA:
undetectable		 3ua5B-4qxaA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1
(Mus
musculus) 		4 / 5 ASN B 294
PRO B 275
GLY B 276
ASP B 270
 None
 1.14A 4n48B-4qxaB:
undetectable		 4n48B-4qxaB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		4 / 6 GLN A 139
GLU A 137
TRP A 141
ALA A 140
 None
 1.38A 6f6jC-4qxaA:
undetectable
6f6jD-4qxaA:
undetectable		 6f6jC-4qxaA:
18.90
6f6jD-4qxaA:
18.90