SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 LEU A 285
THR A 224
ILE A 241
TYR A 242
 None
 1.02A 1qvtA-4qxdA:
undetectable		 1qvtA-4qxdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.32A 2bteA-4qxdA:
undetectable		 2bteA-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.34A 2bteD-4qxdA:
undetectable		 2bteD-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.26A 2v0gA-4qxdA:
undetectable		 2v0gA-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ASP A  45
ASP A  70
ASP A 109
 PO4  A 301 ( 4.9A)
None
MG  A 304 ( 3.2A)
 0.77A 3douA-4qxdA:
undetectable		 3douA-4qxdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 PRO A 163
LEU A 164
GLN A 207
 None
 0.42A 3hznG-4qxdA:
undetectable
3hznH-4qxdA:
undetectable		 3hznG-4qxdA:
20.27
3hznH-4qxdA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 TYR A  60
VAL A 128
GLY A 127
LEU A 225
ILE A 152
 None
 1.17A 3ijdB-4qxdA:
undetectable		 3ijdB-4qxdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 TYR A 212
ILE A 211
TYR A 275
ILE A 279
ILE A 182
 None
 1.15A 3vrjA-4qxdA:
undetectable
3vrjC-4qxdA:
undetectable		 3vrjA-4qxdA:
18.45
3vrjC-4qxdA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 ILE A 101
ILE A 136
ALA A   9
GLU A   7
 None
 0.84A 4jltA-4qxdA:
undetectable		 4jltA-4qxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 ASP A 223
ASP A 109
ASP A 106
ILE A  23
 MG  A 304 (-2.6A)
MG  A 304 ( 3.2A)
MG  A 302 (-2.4A)
None
 0.85A 4xjeA-4qxdA:
undetectable		 4xjeA-4qxdA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 ASP A 223
ASP A 109
ASP A 106
ILE A  23
 MG  A 304 (-2.6A)
MG  A 304 ( 3.2A)
MG  A 302 (-2.4A)
None
 0.90A 5cfsA-4qxdA:
undetectable		 5cfsA-4qxdA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 5 VAL A 229
LEU A 225
HIS A 258
THR A 129
 None
 1.32A 6dyoA-4qxdA:
undetectable		 6dyoA-4qxdA:
14.63