SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A  77
ILE A  69
LEU A  72
PRO A  73
THR A  59
 None
 1.05A 1jolB-4qxeA:
undetectable		 1jolB-4qxeA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 ASP A 147
PHE A 149
VAL A 144
 None
 0.59A 1kijB-4qxeA:
undetectable		 1kijB-4qxeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 LEU A 232
LEU A 216
VAL A 168
LEU A 182
PHE A 221
 None
 1.13A 1tbfA-4qxeA:
undetectable		 1tbfA-4qxeA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 LEU A 367
ASN A 399
ILE A 377
LEU A 358
PHE A 385
 None
 1.22A 1tw4A-4qxeA:
undetectable		 1tw4A-4qxeA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		6 / 10 PHE A 240
ASN A 258
ILE A 260
ILE A 277
LEU A 253
PHE A 268
 None
 1.49A 1z11D-4qxeA:
undetectable		 1z11D-4qxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 PRO A  32
GLY A  47
ASN A  67
GLY A  45
 None
 0.94A 1zlqA-4qxeA:
undetectable		 1zlqA-4qxeA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.91A 2aoiA-4qxeA:
undetectable		 2aoiA-4qxeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 ILE A  64
SER A  44
ASP A  42
LEU A  62
 None
 0.97A 2cdqA-4qxeA:
undetectable		 2cdqA-4qxeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 VAL A 120
LEU A 184
LEU A 173
PHE A 149
LEU A 155
 None
 1.24A 2oipC-4qxeA:
undetectable		 2oipC-4qxeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 173
PHE A 197
LEU A 179
ILE A 189
SER A 133
 None
 1.22A 2po7B-4qxeA:
undetectable		 2po7B-4qxeA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.89A 2pynA-4qxeA:
undetectable		 2pynA-4qxeA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 LEU A  48
GLN A  71
ILE A  64
ALA A  76
LEU A  86
 None
 1.20A 2q72A-4qxeA:
undetectable		 2q72A-4qxeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 ILE A  69
PRO A 121
LEU A 101
ILE A  96
 None
 1.00A 2q83B-4qxeA:
undetectable		 2q83B-4qxeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.89A 3cyxA-4qxeA:
undetectable		 3cyxA-4qxeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.94A 3em4A-4qxeA:
undetectable		 3em4A-4qxeA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.92A 3k4vD-4qxeA:
undetectable		 3k4vD-4qxeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.88A 3ndtD-4qxeA:
undetectable		 3ndtD-4qxeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.92A 3nduA-4qxeA:
undetectable		 3nduA-4qxeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.93A 3nduB-4qxeA:
undetectable		 3nduB-4qxeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.92A 3nduD-4qxeA:
undetectable		 3nduD-4qxeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 VAL A 404
LEU A 435
PHE A 385
LEU A 412
 None
 1.03A 3qeoB-4qxeA:
undetectable		 3qeoB-4qxeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.91A 3tkgB-4qxeA:
undetectable		 3tkgB-4qxeA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY A  90
GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.94A 3tkgC-4qxeA:
undetectable		 3tkgC-4qxeA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 LEU A 152
SER A 148
LEU A 158
LEU A 128
 None
 1.11A 4n09A-4qxeA:
undetectable		 4n09A-4qxeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 ILE A 260
HIS A 278
PHE A 240
THR A 276
 None
 0.81A 4n16A-4qxeA:
undetectable		 4n16A-4qxeA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU A 247
ASN A 271
LEU A 232
ILE A 263
 None
 1.02A 4ok1A-4qxeA:
undetectable		 4ok1A-4qxeA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU A 247
ASN A 271
LEU A 232
ILE A 277
 None
 0.94A 4okxA-4qxeA:
undetectable		 4okxA-4qxeA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 10 SER A 215
LEU A 206
LEU A 184
SER A 191
LEU A 173
 None
 1.21A 4yiaA-4qxeA:
undetectable		 4yiaA-4qxeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A  77
ILE A  69
LEU A  72
PRO A  73
THR A  59
 None
 0.99A 5eajB-4qxeA:
undetectable		 5eajB-4qxeA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 298
THR A 318
GLY A 317
VAL A 287
ILE A 303
 None
 1.11A 5tuiB-4qxeA:
undetectable		 5tuiB-4qxeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0B-4qxeA:
undetectable		 6ew0B-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.12A 6ew0B-4qxeA:
undetectable		 6ew0B-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0D-4qxeA:
undetectable		 6ew0D-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.12A 6ew0D-4qxeA:
undetectable		 6ew0D-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0F-4qxeA:
undetectable		 6ew0F-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0G-4qxeA:
undetectable		 6ew0G-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.04A 6ew0H-4qxeA:
undetectable		 6ew0H-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.12A 6ew0H-4qxeA:
undetectable		 6ew0H-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0I-4qxeA:
undetectable		 6ew0I-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.11A 6ew0I-4qxeA:
undetectable		 6ew0I-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 PHE A  77
LEU A 101
ALA A 100
ASN A  91
 None
 1.00A 6f88A-4qxeA:
undetectable		 6f88A-4qxeA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 PHE A 197
ALA A 196
SER A 217
ASN A 211
 None
 0.82A 6f88A-4qxeA:
undetectable		 6f88A-4qxeA:
12.04