SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 1c9sB-4qyrA:
undetectable
1c9sC-4qyrA:
undetectable
1c9sB-4qyrA:
7.32
1c9sC-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.33A 1c9sG-4qyrA:
undetectable
1c9sH-4qyrA:
undetectable
1c9sG-4qyrA:
7.32
1c9sH-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 9 VAL A2781
VAL A2800
ILE A2725
ALA A2721
LEU A2718
None
1.12A 1eqgA-4qyrA:
undetectable
1eqgA-4qyrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 VAL A2781
VAL A2971
VAL A2800
ILE A2725
LEU A2718
None
1.04A 1fe2A-4qyrA:
undetectable
1fe2A-4qyrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A2575
LEU A2569
LEU A2902
ALA A2899
LEU A2562
None
1.26A 1g5yB-4qyrA:
undetectable
1g5yB-4qyrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.36A 1gtfC-4qyrA:
undetectable
1gtfD-4qyrA:
undetectable
1gtfC-4qyrA:
7.32
1gtfD-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.33A 1gtfG-4qyrA:
undetectable
1gtfH-4qyrA:
undetectable
1gtfG-4qyrA:
7.32
1gtfH-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 1gtfH-4qyrA:
undetectable
1gtfI-4qyrA:
undetectable
1gtfH-4qyrA:
7.32
1gtfI-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 VAL A2608
LEU A2741
LEU A2740
ALA A2896
GOL  A3201 (-4.1A)
None
None
None
0.85A 1j8uA-4qyrA:
undetectable
1j8uA-4qyrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 VAL A2661
SER A2662
GLY A2737
ASN A2739
GLY A2900
None
0.88A 1jg4A-4qyrA:
undetectable
1jg4A-4qyrA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 LEU A2882
ALA A2862
VAL A2934
LEU A2926
HIS A2969
None
1.39A 1kt7A-4qyrA:
undetectable
1kt7A-4qyrA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 8 ASP A2560
GLU A2776
GLY A2777
ASP A2609
None
None
None
GOL  A3201 (-3.8A)
0.70A 1m4iA-4qyrA:
undetectable
1m4iA-4qyrA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
None
1.35A 1mj2B-4qyrA:
undetectable
1mj2B-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
None
1.34A 1mj2D-4qyrA:
undetectable
1mj2D-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
None
1.35A 1mjoB-4qyrA:
undetectable
1mjoB-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
None
1.35A 1mjoA-4qyrA:
undetectable
1mjoA-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
None
1.34A 1mjoD-4qyrA:
undetectable
1mjoD-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 9 LEU A2902
VAL A2778
GLY A2737
ALA A2895
SER A2714
None
1.26A 1pxxB-4qyrA:
undetectable
1pxxB-4qyrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 LEU A2902
VAL A2778
GLY A2737
ALA A2895
SER A2714
None
1.26A 1pxxD-4qyrA:
undetectable
1pxxD-4qyrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ALA A2552
VAL A2637
TRP A2638
None
0.94A 1tkqA-4qyrA:
undetectable
1tkqA-4qyrA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 HIS A2719
SER A2803
LEU A2898
VAL A2781
ALA A2552
None
1.10A 1tlsA-4qyrA:
undetectable
1tlsA-4qyrA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 HIS A2719
SER A2803
LEU A2898
VAL A2781
ALA A2552
None
1.10A 1tlsB-4qyrA:
undetectable
1tlsB-4qyrA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 HIS A2719
SER A2803
LEU A2898
VAL A2781
ALA A2552
None
1.06A 1tsnA-4qyrA:
undetectable
1tsnA-4qyrA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 8 ARG A2801
HIS A2719
SER A2803
VAL A2800
None
1.36A 1u1jA-4qyrA:
undetectable
1u1jA-4qyrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 GLY A3045
HIS A3071
THR A3057
ILE A2993
ARG A3060
None
1.36A 1utdM-4qyrA:
undetectable
1utdN-4qyrA:
undetectable
1utdM-4qyrA:
7.32
1utdN-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 6 PHE A3136
THR A2636
VAL A2637
LEU A2641
ALA A3133
None
1.26A 2e1qC-4qyrA:
undetectable
2e1qC-4qyrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A2570
ASP A3020
ASP A3015
None
0.68A 2ejtA-4qyrA:
undetectable
2ejtA-4qyrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ALA A2892
ILE A2605
GLY A2603
ILE A2576
LEU A2569
None
1.01A 2o4nA-4qyrA:
undetectable
2o4nA-4qyrA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 PHE A2961
LEU A2715
LEU A2972
VAL A2800
VAL A2841
None
1.30A 2po5B-4qyrA:
undetectable
2po5B-4qyrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 PHE A2961
LEU A2715
LEU A2972
VAL A2800
VAL A2841
None
1.36A 2qd4B-4qyrA:
2.5
2qd4B-4qyrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ALA A2862
MET A2830
ALA A2829
VAL A2971
CYH A2944
None
1.23A 3b0wA-4qyrA:
undetectable
3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A2825
ALA A2862
MET A2830
ALA A2829
VAL A2971
None
1.20A 3b0wA-4qyrA:
undetectable
3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 LEU A2898
MET A2908
ILE A2725
ASP A2794
None
1.21A 3hecA-4qyrA:
undetectable
3hecA-4qyrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A2905
VAL A2657
ALA A2552
GLY A2551
LEU A2641
None
0.82A 3ku1A-4qyrA:
undetectable
3ku1A-4qyrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A2905
VAL A2657
ALA A2552
GLY A2551
LEU A2641
None
0.80A 3ku1C-4qyrA:
undetectable
3ku1C-4qyrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A2905
VAL A2657
ALA A2552
GLY A2551
LEU A2641
None
0.75A 3ku1G-4qyrA:
undetectable
3ku1G-4qyrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 VAL A2778
ILE A2549
GLY A2551
ALA A2552
LEU A2562
None
0.99A 3n8yB-4qyrA:
undetectable
3n8yB-4qyrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 5 LEU A2625
ARG A2631
LEU A2670
PRO A3144
None
1.29A 3onnA-4qyrA:
undetectable
3onnA-4qyrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 VAL A2781
ALA A2735
GLY A2736
ALA A2968
LEU A2905
None
1.18A 3rc0A-4qyrA:
undetectable
3rc0A-4qyrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 VAL A2781
ALA A2735
GLY A2736
ALA A2968
LEU A2905
None
1.18A 3rc0B-4qyrA:
undetectable
3rc0B-4qyrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ALA A2779
GLN A2568
THR A2564
ILE A2889
PHE A2565
None
1.25A 4c49A-4qyrA:
undetectable
4c49A-4qyrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 THR A3057
LEU A2995
LEU A3044
GLY A3045
VAL A3048
None
1.26A 4c9nB-4qyrA:
undetectable
4c9nB-4qyrA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 GLY A2777
ALA A2899
LEU A2902
GLY A2554
ALA A2546
None
1.18A 4l6v1-4qyrA:
undetectable
4l6v6-4qyrA:
undetectable
4l6v1-4qyrA:
24.44
4l6v6-4qyrA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2710
CYH A2711
HIS A2844
HIS A2891
GLY A2962
PHE A2963
None
0.93A 4ls7A-4qyrA:
48.7
4ls7A-4qyrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2710
CYH A2711
HIS A2844
THR A2846
HIS A2891
GLY A2962
None
0.56A 4ls7A-4qyrA:
48.7
4ls7A-4qyrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2710
CYH A2711
HIS A2844
HIS A2891
GLY A2962
PHE A2963
None
0.96A 4ls7A-4qyrA:
48.7
4ls7B-4qyrA:
48.4
4ls7A-4qyrA:
21.38
4ls7B-4qyrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2710
CYH A2711
HIS A2844
THR A2846
HIS A2891
GLY A2962
None
0.55A 4ls7A-4qyrA:
48.7
4ls7B-4qyrA:
48.4
4ls7A-4qyrA:
21.38
4ls7B-4qyrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 ILE A2838
VAL A2958
VAL A2971
ARG A2955
None
1.33A 4m6tA-4qyrA:
undetectable
4m6tA-4qyrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 LEU A3108
ASP A3099
VAL A3047
ALA A2992
None
1.19A 4nkvC-4qyrA:
undetectable
4nkvC-4qyrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 9 ALA A2717
SER A2695
GLY A2656
ALA A2733
VAL A2637
None
1.24A 4r1zA-4qyrA:
undetectable
4r1zA-4qyrA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 GLY A3045
PHE A3061
LEU A3058
ALA A3007
ALA A2997
None
1.18A 4wnuD-4qyrA:
undetectable
4wnuD-4qyrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.29A 5eeuD-4qyrA:
undetectable
5eeuE-4qyrA:
undetectable
5eeuD-4qyrA:
7.32
5eeuE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5eeuH-4qyrA:
undetectable
5eeuI-4qyrA:
undetectable
5eeuH-4qyrA:
7.32
5eeuI-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 5eeuJ-4qyrA:
undetectable
5eeuK-4qyrA:
undetectable
5eeuJ-4qyrA:
7.32
5eeuK-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.29A 5eevD-4qyrA:
undetectable
5eevE-4qyrA:
undetectable
5eevD-4qyrA:
7.32
5eevE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 5eevJ-4qyrA:
undetectable
5eevK-4qyrA:
undetectable
5eevJ-4qyrA:
7.32
5eevK-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5eewD-4qyrA:
undetectable
5eewE-4qyrA:
undetectable
5eewD-4qyrA:
7.32
5eewE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.33A 5eewH-4qyrA:
undetectable
5eewI-4qyrA:
undetectable
5eewH-4qyrA:
7.32
5eewI-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 5eewJ-4qyrA:
undetectable
5eewK-4qyrA:
undetectable
5eewJ-4qyrA:
7.32
5eewK-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5eexD-4qyrA:
undetectable
5eexE-4qyrA:
undetectable
5eexD-4qyrA:
7.32
5eexE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.33A 5eexH-4qyrA:
undetectable
5eexI-4qyrA:
undetectable
5eexH-4qyrA:
7.32
5eexI-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5eexI-4qyrA:
undetectable
5eexJ-4qyrA:
undetectable
5eexI-4qyrA:
7.32
5eexJ-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 5eexJ-4qyrA:
undetectable
5eexK-4qyrA:
undetectable
5eexJ-4qyrA:
7.32
5eexK-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5eeyD-4qyrA:
undetectable
5eeyE-4qyrA:
undetectable
5eeyD-4qyrA:
7.32
5eeyE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5eeyI-4qyrA:
undetectable
5eeyJ-4qyrA:
undetectable
5eeyI-4qyrA:
7.32
5eeyJ-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.34A 5eeyJ-4qyrA:
undetectable
5eeyK-4qyrA:
undetectable
5eeyJ-4qyrA:
7.32
5eeyK-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5eezD-4qyrA:
undetectable
5eezE-4qyrA:
undetectable
5eezD-4qyrA:
7.32
5eezE-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5eezI-4qyrA:
undetectable
5eezJ-4qyrA:
undetectable
5eezI-4qyrA:
7.32
5eezJ-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5ef0D-4qyrA:
undetectable
5ef0E-4qyrA:
undetectable
5ef0D-4qyrA:
7.32
5ef0E-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5ef0I-4qyrA:
undetectable
5ef0J-4qyrA:
undetectable
5ef0I-4qyrA:
7.32
5ef0J-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5ef1D-4qyrA:
undetectable
5ef1E-4qyrA:
undetectable
5ef1D-4qyrA:
7.32
5ef1E-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5ef1I-4qyrA:
undetectable
5ef1J-4qyrA:
undetectable
5ef1I-4qyrA:
7.32
5ef1J-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5ef2D-4qyrA:
undetectable
5ef2E-4qyrA:
undetectable
5ef2D-4qyrA:
7.32
5ef2E-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5ef2I-4qyrA:
undetectable
5ef2J-4qyrA:
undetectable
5ef2I-4qyrA:
7.32
5ef2J-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.30A 5ef3D-4qyrA:
undetectable
5ef3E-4qyrA:
undetectable
5ef3D-4qyrA:
7.32
5ef3E-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ARG A3060
GLY A3045
HIS A3071
THR A3057
ILE A2993
None
1.32A 5ef3I-4qyrA:
undetectable
5ef3J-4qyrA:
undetectable
5ef3I-4qyrA:
7.32
5ef3J-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A2774
ASN A2739
ASP A2627
None
0.93A 5gwxA-4qyrA:
undetectable
5gwxA-4qyrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ALA A2895
ALA A2633
ALA A2779
THR A2636
LEU A2905
None
1.01A 5lf7H-4qyrA:
undetectable
5lf7I-4qyrA:
undetectable
5lf7H-4qyrA:
18.20
5lf7I-4qyrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 ALA A2895
ALA A2633
ALA A2779
THR A2636
LEU A2905
None
1.00A 5lf7V-4qyrA:
undetectable
5lf7W-4qyrA:
undetectable
5lf7V-4qyrA:
18.20
5lf7W-4qyrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 GLY A2965
PHE A2961
SER A2712
ARG A2810
None
0.86A 5n5dB-4qyrA:
undetectable
5n5dB-4qyrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 PHE A2659
GLY A2660
GLY A2737
GLU A2776
LEU A2742
None
1.20A 5ul4A-4qyrA:
undetectable
5ul4A-4qyrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 8 GLY A3064
ARG A3011
TRP A3070
ASP A3059
None
1.02A 5vlmB-4qyrA:
undetectable
5vlmB-4qyrA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2968
ALA A2966
GLY A2736
ALA A2735
SER A2662
VAL A2707
None
None
None
None
None
ACY  A3202 (-3.5A)
1.32A 5w4zA-4qyrA:
undetectable
5w4zA-4qyrA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 12 ALA A2968
ALA A2966
GLY A2736
ALA A2735
SER A2662
VAL A2707
None
None
None
None
None
ACY  A3202 (-3.5A)
1.37A 5w4zB-4qyrA:
undetectable
5w4zB-4qyrA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 SER A2959
GLY A2900
ALA A2899
SER A2713
GLU A2855
None
1.45A 5wbvA-4qyrA:
undetectable
5wbvA-4qyrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 SER A2959
GLY A2900
ALA A2899
SER A2713
GLU A2855
None
1.46A 5wbvB-4qyrA:
undetectable
5wbvB-4qyrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 MET A2732
ASP A2794
ARG A3037
None
0.85A 5z6jA-4qyrA:
undetectable
5z6jA-4qyrA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 MET A2732
ASP A2794
ARG A3037
None
0.97A 5z6kA-4qyrA:
undetectable
5z6kA-4qyrA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 PHE A3046
ILE A2993
GLY A3008
ALA A3007
LEU A3003
None
1.17A 5zwrA-4qyrA:
undetectable
5zwrA-4qyrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TRP A2952
ILE A2833
ASP A2834
None
0.89A 6i0y7-4qyrA:
undetectable
6i0y7-4qyrA:
3.09