SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 LEU B 201
VAL B 118
VAL B  77
LEU B  23
LEU B  36
 None
 1.08A 1mx1E-4qzvB:
undetectable		 1mx1E-4qzvB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 ARG B  91
ILE B  98
ALA B  81
ALA B 116
GLU B  56
 None
 1.18A 2j0dA-4qzvB:
undetectable		 2j0dA-4qzvB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		4 / 4 THR B  76
VAL B 218
GLY B 212
THR B 213
 None
 1.10A 3cflA-4qzvB:
undetectable		 3cflA-4qzvB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 9 ILE B  62
ILE B 207
PHE B  19
PHE B  38
VAL B 209
 None
 1.39A 4afgA-4qzvB:
undetectable
4afgE-4qzvB:
undetectable		 4afgA-4qzvB:
21.72
4afgE-4qzvB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 VAL B 118
GLN B 202
PRO B  28
ALA B  27
ILE B  90
 None
 1.20A 5hv1A-4qzvB:
undetectable		 5hv1A-4qzvB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4qzv SPIKE PROTEIN S1
(Tylonycteris
bat
coronavirus
HKU4) 		4 / 7 THR B  76
ASP B  78
TYR B 103
GLY B 155
 None
 1.12A 5hwaA-4qzvB:
undetectable		 5hwaA-4qzvB:
21.35