SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 THR A 728
THR A 726
PRO A 730
 None
 0.87A 1a7yB-4r04A:
undetectable		 1a7yB-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 LEU A 799
SER A 801
ASN A1801
 None
 0.82A 1bx4A-4r04A:
undetectable		 1bx4A-4r04A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 11 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.07A 1dhiB-4r04A:
undetectable		 1dhiB-4r04A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.02A 1draA-4r04A:
undetectable		 1draA-4r04A:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.06A 1draB-4r04A:
undetectable		 1draB-4r04A:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 VAL A1530
ASN A1558
GLY A1612
LEU A1610
 None
 0.87A 1dzmA-4r04A:
1.4		 1dzmA-4r04A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 7 LEU A 362
LEU A 386
GLY A 281
LEU A  97
 None
 0.73A 1gtiA-4r04A:
undetectable		 1gtiA-4r04A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 9 MET A1073
GLU A1063
LEU A1069
MET A1517
HIS A1484
 None
 1.44A 1gwrB-4r04A:
undetectable		 1gwrB-4r04A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 THR A 726
PRO A 730
THR A 728
 None
 0.85A 1i3wE-4r04A:
undetectable		 1i3wE-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 LEU A 673
PHE A 652
TYR A 636
VAL A 695
 None
 0.76A 1ibgH-4r04A:
undetectable		 1ibgH-4r04A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 TRP A1345
SER A1325
ASP A1343
THR A1296
 None
 1.02A 1ig3A-4r04A:
2.0
1ig3B-4r04A:
2.4		 1ig3A-4r04A:
8.73
1ig3B-4r04A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 THR A 662
TYR A 713
ILE A 739
ILE A 780
TYR A 779
 None
 1.06A 1jtxA-4r04A:
undetectable		 1jtxA-4r04A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 TYR A1205
GLU A1131
ILE A1164
GLY A1167
 None
 1.03A 1maaB-4r04A:
undetectable
1maaD-4r04A:
3.1		 1maaB-4r04A:
14.40
1maaD-4r04A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 THR A 726
PRO A 730
THR A 728
 None
 0.87A 1ovfB-4r04A:
undetectable		 1ovfB-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 THR A 728
THR A 726
PRO A 730
 None
 0.82A 1qfiB-4r04A:
undetectable		 1qfiB-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 GLU A 354
GLU A 350
TYR A 325
ILE A 358
 None
 1.13A 1qvtA-4r04A:
undetectable		 1qvtA-4r04A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1256
LEU A1129
PHE A1126
LEU A1279
ILE A1171
 None
 1.05A 1rb2B-4r04A:
undetectable		 1rb2B-4r04A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.00A 1rb3B-4r04A:
undetectable		 1rb3B-4r04A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 7 PHE A  58
LEU A  71
THR A  25
TYR A  23
 None
 1.20A 1rmtB-4r04A:
undetectable		 1rmtB-4r04A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 ASP A1784
TYR A1792
LEU A1788
ASP A1781
 None
 0.77A 1rmtC-4r04A:
undetectable		 1rmtC-4r04A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 ASP A1784
TYR A1792
LEU A1788
ASP A1781
 None
 0.76A 1rmtD-4r04A:
undetectable		 1rmtD-4r04A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 ALA A 134
GLU A 133
ILE A 239
LEU A 258
 None
 1.02A 1xvaA-4r04A:
2.5
1xvaB-4r04A:
2.6		 1xvaA-4r04A:
9.77
1xvaB-4r04A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 PRO A1137
LEU A1166
GLY A1167
PRO A1225
 None
 0.83A 1ya4A-4r04A:
undetectable		 1ya4A-4r04A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1157
LEU A1326
MET A1223
ILE A1333
ILE A1288
 None
 0.85A 2bl9A-4r04A:
undetectable		 2bl9A-4r04A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 588
ASP A 589
ASP A 545
ASN A 613
ALA A 666
 None
None
ZN  A1901 (-3.4A)
None
None
 1.04A 2bm9B-4r04A:
undetectable		 2bm9B-4r04A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.02A 2drcA-4r04A:
undetectable		 2drcA-4r04A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 ARG A 310
TRP A 311
GLU A 312
ALA A 318
 None
 1.48A 2ejfB-4r04A:
undetectable		 2ejfB-4r04A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 7 ARG A 310
TRP A 311
GLU A 312
ALA A 318
 None
 1.36A 2ejgA-4r04A:
undetectable		 2ejgA-4r04A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 ASP A 731
PRO A 690
SER A 736
VAL A 693
 None
 1.26A 2hdnI-4r04A:
undetectable
2hdnJ-4r04A:
2.2
2hdnL-4r04A:
2.1		 2hdnI-4r04A:
2.67
2hdnJ-4r04A:
10.53
2hdnL-4r04A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 SER A 736
VAL A 693
ASP A 731
PRO A 690
 None
 1.26A 2hdnJ-4r04A:
2.2
2hdnK-4r04A:
undetectable
2hdnL-4r04A:
2.1		 2hdnJ-4r04A:
10.53
2hdnK-4r04A:
2.67
2hdnL-4r04A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 ILE A1031
PRO A1032
PHE A1608
ILE A1542
 None
 0.99A 2hjhA-4r04A:
undetectable		 2hjhA-4r04A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 PHE A1591
PHE A1595
PHE A1503
VAL A1552
 None
 1.18A 2lh6A-4r04A:
undetectable		 2lh6A-4r04A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 PHE A 550
GLN A 585
ASN A 613
LEU A 697
 None
 1.28A 2nyrA-4r04A:
undetectable		 2nyrA-4r04A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 LEU A   9
LEU A  12
ILE A  26
ARG A  67
 None
 0.93A 2rlfA-4r04A:
undetectable
2rlfB-4r04A:
undetectable		 2rlfA-4r04A:
2.59
2rlfB-4r04A:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A1044
LEU A1555
GLY A1554
ILE A1604
ASP A1605
 None
 1.02A 2zbpA-4r04A:
undetectable		 2zbpA-4r04A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 11 HIS A 581
ILE A 584
ILE A 684
ILE A 721
PHE A 680
 None
 1.15A 3b2rB-4r04A:
undetectable		 3b2rB-4r04A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 LEU A 453
GLN A 256
HIS A 431
LEU A 434
 None
 1.13A 3ce6D-4r04A:
2.9		 3ce6D-4r04A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1171
LEU A1259
ILE A1208
LEU A1252
ILE A1204
 None
 1.06A 3drcB-4r04A:
undetectable		 3drcB-4r04A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 MET A1073
ALA A1070
GLU A1063
LEU A1051
LEU A1050
 None
 1.41A 3erdB-4r04A:
undetectable		 3erdB-4r04A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 ALA A1227
ILE A1309
ASN A1226
PRO A1106
 None
 0.89A 3fxrA-4r04A:
undetectable		 3fxrA-4r04A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 SER A1316
ASP A1318
ASP A1391
 None
 0.81A 3iv6A-4r04A:
undetectable		 3iv6A-4r04A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 LYS A 448
ILE A 374
PHE A 500
 None
 0.95A 3j7zS-4r04A:
undetectable
3j7za-4r04A:
undetectable		 3j7zS-4r04A:
5.14
3j7za-4r04A:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 9 VAL A1034
GLY A1044
VAL A1611
ASN A1553
GLY A1554
 None
 1.28A 3kmoA-4r04A:
undetectable		 3kmoA-4r04A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.20A 3ko0A-4r04A:
undetectable
3ko0B-4r04A:
undetectable
3ko0C-4r04A:
undetectable
3ko0D-4r04A:
undetectable		 3ko0A-4r04A:
4.44
3ko0B-4r04A:
4.44
3ko0C-4r04A:
4.44
3ko0D-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.25A 3ko0G-4r04A:
undetectable
3ko0H-4r04A:
undetectable
3ko0I-4r04A:
undetectable
3ko0J-4r04A:
undetectable		 3ko0G-4r04A:
4.44
3ko0H-4r04A:
4.44
3ko0I-4r04A:
4.44
3ko0J-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.16A 3ko0K-4r04A:
undetectable
3ko0L-4r04A:
undetectable
3ko0S-4r04A:
undetectable
3ko0T-4r04A:
undetectable		 3ko0K-4r04A:
4.44
3ko0L-4r04A:
4.44
3ko0S-4r04A:
4.44
3ko0T-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A  74
LEU A  51
SER A  54
ILE A  78
PHE A1722
 None
 1.22A 3ko0K-4r04A:
undetectable
3ko0L-4r04A:
undetectable
3ko0M-4r04A:
undetectable
3ko0N-4r04A:
undetectable		 3ko0K-4r04A:
4.44
3ko0L-4r04A:
4.44
3ko0M-4r04A:
4.44
3ko0N-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A  74
LEU A  51
SER A  54
ILE A  78
PHE A1722
 None
 1.17A 3ko0M-4r04A:
undetectable
3ko0N-4r04A:
undetectable
3ko0O-4r04A:
undetectable
3ko0P-4r04A:
undetectable		 3ko0M-4r04A:
4.44
3ko0N-4r04A:
4.44
3ko0O-4r04A:
4.44
3ko0P-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A1350
VAL A1085
ILE A1084
ILE A1346
SER A1325
 None
 1.24A 3kpbA-4r04A:
undetectable		 3kpbA-4r04A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 ASP A1350
VAL A1085
ILE A1084
ILE A1346
SER A1325
 None
 1.27A 3kpbD-4r04A:
undetectable		 3kpbD-4r04A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 PRO A1677
LEU A1566
ASP A1567
LYS A1570
 None
 0.98A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 SER A 727
SER A 678
LEU A 681
ASP A 682
 None
 0.89A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 SER A1563
LEU A1566
ASP A1567
LYS A1570
 None
 0.79A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 VAL A 106
ILE A 231
PHE A 135
ALA A 134
ILE A 239
 None
 1.05A 3me6A-4r04A:
undetectable		 3me6A-4r04A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
 1.25A 3mteA-4r04A:
2.3		 3mteA-4r04A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.01A 3mteB-4r04A:
undetectable		 3mteB-4r04A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 LYS A 565
ARG A 747
ASP A 590
 None
 1.37A 3o7wA-4r04A:
undetectable		 3o7wA-4r04A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		6 / 9 ILE A 967
ILE A 931
GLN A 994
ALA A 993
LEU A 991
ALA A 963
 None
 1.34A 3ozvB-4r04A:
undetectable		 3ozvB-4r04A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.04A 3p2kA-4r04A:
undetectable		 3p2kA-4r04A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		6 / 12 GLY A 262
VAL A 455
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.34A 3p2kC-4r04A:
undetectable		 3p2kC-4r04A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.02A 3p2kD-4r04A:
2.6		 3p2kD-4r04A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 ILE A1629
TYR A1565
LEU A1557
PHE A1585
 None
 1.05A 3rqwI-4r04A:
undetectable
3rqwJ-4r04A:
undetectable		 3rqwI-4r04A:
10.35
3rqwJ-4r04A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 PHE A1673
TYR A1705
LEU A1698
 None
 0.80A 3sueB-4r04A:
undetectable		 3sueB-4r04A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 9 ILE A1589
VAL A1552
PHE A1602
PHE A1585
LEU A1555
 None
 1.34A 3ti1A-4r04A:
undetectable		 3ti1A-4r04A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 7 ILE A 739
ILE A 677
SER A 736
THR A 728
 None
 0.86A 3ua5B-4r04A:
undetectable		 3ua5B-4r04A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1358
GLY A1100
ASP A1151
VAL A1147
PRO A1302
 None
 1.18A 3v8vA-4r04A:
undetectable		 3v8vA-4r04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 11 GLY A1100
ASP A1150
ASP A1151
VAL A1147
PRO A1302
 None
 1.00A 3v8vB-4r04A:
undetectable		 3v8vB-4r04A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 ASP A 805
THR A 808
LEU A 809
GLU A 767
 None
 1.00A 4a3pA-4r04A:
undetectable		 4a3pA-4r04A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 ILE A 239
ILE A 270
TYR A 254
GLU A 257
 None
 1.21A 4a99D-4r04A:
undetectable		 4a99D-4r04A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 VAL A1655
PHE A1673
SER A1674
LEU A1678
VAL A1653
 None
 1.13A 4eckB-4r04A:
undetectable		 4eckB-4r04A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 7 TYR A 393
LEU A 370
ASN A  43
TYR A  33
 None
 1.07A 4f8yC-4r04A:
4.7
4f8yD-4r04A:
4.9		 4f8yC-4r04A:
6.75
4f8yD-4r04A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 8 SER A1035
GLU A1620
TYR A1618
GLY A1030
 None
 1.02A 4fgzA-4r04A:
undetectable
4fgzB-4r04A:
2.5		 4fgzA-4r04A:
9.58
4fgzB-4r04A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 11 ILE A1538
TYR A1565
LEU A1555
VAL A1552
LEU A1586
 None
 1.14A 4g1bB-4r04A:
2.7		 4g1bB-4r04A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 9 ILE A1538
TYR A1565
LEU A1555
VAL A1552
LEU A1586
 None
 1.10A 4g1bC-4r04A:
3.0		 4g1bC-4r04A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1538
TYR A1565
LEU A1555
VAL A1552
LEU A1586
 None
 1.13A 4g1bD-4r04A:
2.6		 4g1bD-4r04A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 GLU A 573
THR A 651
HIS A 581
 None
 0.72A 4q15A-4r04A:
2.3		 4q15A-4r04A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 GLU A 573
THR A 651
HIS A 581
 None
 0.71A 4q15B-4r04A:
2.0		 4q15B-4r04A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 6 ASN A1558
GLU A1029
TYR A1562
GLU A1559
 None
 1.37A 4r87H-4r04A:
undetectable		 4r87H-4r04A:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 4 THR A1523
GLY A1526
ASP A1512
SER A1541
 None
 1.13A 4rfqA-4r04A:
undetectable		 4rfqA-4r04A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 PHE A1317
ALA A1320
SER A1340
ILE A1157
TYR A1315
 None
 1.30A 4rtpA-4r04A:
undetectable		 4rtpA-4r04A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 CYH A1407
LEU A1415
LEU A1405
VAL A1353
ILE A1385
 None
 1.11A 4x1yB-4r04A:
undetectable		 4x1yB-4r04A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 GLU A 573
THR A 651
HIS A 581
 None
 0.79A 4ydqB-4r04A:
2.1		 4ydqB-4r04A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 SER A 380
GLU A 514
GLU A 711
 None
 0.54A 4ymgB-4r04A:
undetectable		 4ymgB-4r04A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 ARG A1230
PHE A1126
LEU A1202
ILE A1256
SER A1206
 None
 1.33A 4z69I-4r04A:
3.7		 4z69I-4r04A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 ASN A 234
SER A 233
ARG A 229
 None
 0.93A 5b2qA-4r04A:
undetectable		 5b2qA-4r04A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4r04 TOXIN A
(Clostridioides
difficile) 		4 / 5 GLU A 531
TYR A 528
SER A 541
ASP A 545
 None
None
None
ZN  A1901 (-3.4A)
 1.44A 5fhrA-4r04A:
undetectable		 5fhrA-4r04A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A 590
THR A 554
GLN A 611
PHE A 550
GLY A 588
 None
 1.14A 5hfjH-4r04A:
undetectable		 5hfjH-4r04A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 ASP A 590
ASN A 613
GLN A 611
 None
 0.74A 5k7uA-4r04A:
undetectable		 5k7uA-4r04A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 LYS A1486
ASP A1488
ILE A1483
 None
 0.76A 5kc4E-4r04A:
3.2		 5kc4E-4r04A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ALA A1207
PHE A1126
VAL A1231
LEU A1279
VAL A1122
 None
 1.26A 5tudD-4r04A:
2.7		 5tudD-4r04A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 LEU A 365
ILE A 387
GLY A 281
GLY A 280
VAL A 367
 None
 1.05A 5twjB-4r04A:
undetectable		 5twjB-4r04A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 10 MET A1073
GLU A1063
LEU A1069
MET A1517
HIS A1484
 None
 1.38A 5wgqB-4r04A:
undetectable		 5wgqB-4r04A:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A1780
ASN A1700
LEU A1698
ASN A1727
ASP A1731
 None
 1.15A 6dwnB-4r04A:
undetectable		 6dwnB-4r04A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4r04 TOXIN A
(Clostridioides
difficile) 		3 / 3 SER A 776
SER A 772
ALA A 526
 None
 0.66A 6dwnC-4r04A:
undetectable		 6dwnC-4r04A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4r04 TOXIN A
(Clostridioides
difficile) 		5 / 9 LEU A 697
PHE A 680
SER A 679
LEU A 681
ILE A 721
 None
 1.06A 6fdyU-4r04A:
1.2		 6fdyU-4r04A:
8.54