SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 ALA A 172
GLY A 168
GLY A 169
LEU A 474
LEU A 473
 None
 1.00A 1ej0A-4r0cA:
undetectable		 1ej0A-4r0cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		3 / 3 ARG A 450
SER A 469
TYR A 468
 None
 0.64A 1x70A-4r0cA:
undetectable		 1x70A-4r0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 10 GLU A 189
VAL A 348
ALA A 345
MET A 341
SER A 401
 None
 1.34A 2c12D-4r0cA:
1.4		 2c12D-4r0cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 11 GLU A 189
VAL A 348
ALA A 345
MET A 341
SER A 401
 None
 1.32A 2c12F-4r0cA:
1.9		 2c12F-4r0cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 ALA A 365
GLY A 369
ALA A 370
LEU A 413
VAL A 406
 None
 0.98A 2nyuA-4r0cA:
undetectable		 2nyuA-4r0cA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 6 TYR A 468
THR A 228
VAL A 119
VAL A 122
 None
 0.96A 2z97A-4r0cA:
undetectable		 2z97A-4r0cA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 PHE A 382
GLY A 428
ILE A 389
ASN A 390
PHE A 407
 None
None
None
NA  A 801 (-2.9A)
None
 1.27A 2zznA-4r0cA:
undetectable		 2zznA-4r0cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 PHE A 382
GLY A 428
ILE A 389
ASN A 390
PHE A 407
 None
None
None
NA  A 801 (-2.9A)
None
 1.31A 2zznB-4r0cA:
undetectable		 2zznB-4r0cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 102
GLY A 304
VAL A 309
ALA A 300
LEU A 263
 LMT  A 802 ( 4.1A)
LMT  A 806 ( 4.5A)
None
None
None
 0.92A 3dh0A-4r0cA:
undetectable		 3dh0A-4r0cA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 102
GLY A 304
VAL A 309
ALA A 300
LEU A 263
 LMT  A 802 ( 4.1A)
LMT  A 806 ( 4.5A)
None
None
None
 0.94A 3dh0B-4r0cA:
undetectable		 3dh0B-4r0cA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		3 / 3 ALA A 201
VAL A 200
GLN A 422
 None
 0.69A 3of4B-4r0cA:
undetectable		 3of4B-4r0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 6 LEU A 143
ALA A 123
THR A 161
LEU A 118
 None
 1.00A 3t3zB-4r0cA:
undetectable		 3t3zB-4r0cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 411
ILE A 484
LEU A 480
PHE A 382
VAL A 427
 None
 1.19A 3w68A-4r0cA:
undetectable		 3w68A-4r0cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 411
ILE A 484
LEU A 480
PHE A 382
VAL A 427
 None
 1.18A 3w68C-4r0cA:
undetectable		 3w68C-4r0cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 ILE A 402
ALA A 404
ALA A 345
PHE A 347
LEU A  32
 None
 1.00A 4kjjA-4r0cA:
undetectable		 4kjjA-4r0cA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 9 TRP A 483
SER A 187
ALA A 420
LEU A 490
GLY A 204
 None
 1.37A 4l6va-4r0cA:
undetectable
4l6vf-4r0cA:
undetectable		 4l6va-4r0cA:
23.88
4l6vf-4r0cA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 7 PRO A 405
VAL A 348
ALA A 344
PHE A  25
 None
 1.12A 4lb2A-4r0cA:
undetectable		 4lb2A-4r0cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 379
LEU A 480
ILE A 484
PHE A 208
SER A 421
 None
 1.02A 4lmnA-4r0cA:
undetectable		 4lmnA-4r0cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 8 ASP A 134
MET A 327
VAL A 329
THR A 330
 None
LMT  A 806 ( 4.4A)
None
None
 1.05A 4lnwA-4r0cA:
undetectable		 4lnwA-4r0cA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 ILE A 402
ALA A 404
ALA A 345
PHE A 347
LEU A  32
 None
 0.98A 4psyA-4r0cA:
undetectable		 4psyA-4r0cA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 11 ASN A 433
SER A 397
ASP A 429
ARG A 426
PHE A 170
 NA  A 801 (-2.6A)
None
NA  A 801 (-3.1A)
None
None
 1.43A 4xt7A-4r0cA:
undetectable		 4xt7A-4r0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 7 ALA A 201
THR A 203
VAL A 296
HIS A 293
 None
 1.21A 5ecnA-4r0cA:
undetectable		 5ecnA-4r0cA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 GLY A 307
GLY A  94
GLY A 304
THR A 330
GLU A  97
 None
None
LMT  A 806 ( 4.5A)
None
None
 1.01A 5eiwA-4r0cA:
undetectable		 5eiwA-4r0cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 4 GLY A  84
ALA A  81
MET A 341
THR A 188
 None
 1.00A 5n0sB-4r0cA:
undetectable		 5n0sB-4r0cA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 10 TRP A 483
SER A 187
ALA A 420
LEU A 490
GLY A 204
 None
 1.42A 6hqbA-4r0cA:
undetectable
6hqbJ-4r0cA:
undetectable		 6hqbA-4r0cA:
9.54
6hqbJ-4r0cA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 6 THR A 386
LEU A 385
THR A 432
LEU A 380
 None
 1.23A 6mvxA-4r0cA:
undetectable
6mvxB-4r0cA:
undetectable
6mvxC-4r0cA:
2.0		 6mvxA-4r0cA:
18.40
6mvxB-4r0cA:
18.40
6mvxC-4r0cA:
18.40