SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RQP_A_SAMA500_1 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 7	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.20A	1rqpB-4r0jA: undetectable	1rqpB-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RQP_B_SAMB500_1 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 8	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.21A	1rqpC-4r0jA: undetectable	1rqpC-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RQP_C_SAMC500_0 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 8	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.22A	1rqpA-4r0jA: undetectable	1rqpA-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7U_A_SAMA1299_0 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 8	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.21A	2v7uA-4r0jA: undetectable	2v7uA-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7U_B_SAMB1299_1 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 7	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.19A	2v7uB-4r0jA: undetectable	2v7uB-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7U_B_SAMB1300_1 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 9	PHE A 103 ASN A 57 PHE A 101 SER A 128 ARG A 134	None None None SO4 A 303 ( 4.7A) SO4 A 303 (-4.1A)	1.20A	2v7uC-4r0jA: 0.0	2v7uC-4r0jA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AF3_A_PAUA314_0 (PANTOTHENATE KINASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	4 / 6	TYR A 4 ARG A 5 PHE A 103 PHE A 9	None	1.22A	3af3A-4r0jA: undetectable	3af3A-4r0jA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IH0_A_ERYA404_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 12	ILE A 137 GLY A 48 GLU A 143 PHE A 20 ALA A 41	None	1.22A	5ih0A-4r0jA: undetectable	5ih0A-4r0jA: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	4 / 6	PHE A 145 LEU A 147 ARG A 17 GLY A 15	None	1.14A	5o4yA-4r0jA: undetectable	5o4yA-4r0jA: 3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_B_SAMB301_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	4r0j	UNCHARACTERIZED PROTEIN (Streptococcus mutans)	5 / 12	PRO A 37 GLY A 140 VAL A 62 VAL A 99 ILE A 45	None	1.06A	6emuB-4r0jA: undetectable	6emuB-4r0jA: 21.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RQP_A_SAMA500_1","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.20A","1rqpB-4r0jA:undetectable","1rqpB-4r0jA:21.32"],["1RQP_B_SAMB500_1","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.21A","1rqpC-4r0jA:undetectable","1rqpC-4r0jA:21.32"],["1RQP_C_SAMC500_0","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.22A","1rqpA-4r0jA:undetectable","1rqpA-4r0jA:21.32"],["2V7U_A_SAMA1299_0","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.21A","2v7uA-4r0jA:undetectable","2v7uA-4r0jA:21.32"],["2V7U_B_SAMB1299_1","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.19A","2v7uB-4r0jA:undetectable","2v7uB-4r0jA:21.32"],["2V7U_B_SAMB1300_1","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PHE A 103;ASN A  57;PHE A 101;SER A 128;ARG A 134","None;None;None;SO4 A 303 ( 4.7A);SO4 A 303 (-4.1A)","1.20A","2v7uC-4r0jA:0.0","2v7uC-4r0jA:21.32"],["3AF3_A_PAUA314_0","PANTOTHENATE KINASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",4,"TYR A   4;ARG A   5;PHE A 103;PHE A   9","None","1.22A","3af3A-4r0jA:undetectable","3af3A-4r0jA:18.32"],["5IH0_A_ERYA404_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"ILE A 137;GLY A  48;GLU A 143;PHE A  20;ALA A  41","None","1.22A","5ih0A-4r0jA:undetectable","5ih0A-4r0jA:22.08"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",4,"PHE A 145;LEU A 147;ARG A  17;GLY A  15","None","1.14A","5o4yA-4r0jA:undetectable","5o4yA-4r0jA:3.45"],["6EMU_B_SAMB301_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","4r0j","UNCHARACTERIZED PROTEIN","Streptococcus mutans",5,"PRO A  37;GLY A 140;VAL A  62;VAL A  99;ILE A  45","None","1.06A","6emuB-4r0jA:undetectable","6emuB-4r0jA:21.92"]]