SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 144
MET A  52
LEU A  56
GLU A 123
MET A 130
 None
 1.38A 1a29A-4r0sA:
undetectable		 1a29A-4r0sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 129
THR A  34
VAL A  43
GLY A 135
ARG A 147
 None
None
None
PO4  A 301 ( 4.5A)
None
 1.18A 2cbrA-4r0sA:
undetectable		 2cbrA-4r0sA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 12 ARG A  51
THR A  77
VAL A  75
LEU A  69
SER A  59
 None
 1.25A 2fj1A-4r0sA:
undetectable		 2fj1A-4r0sA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 141
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.20A 3pghB-4r0sA:
undetectable		 3pghB-4r0sA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 112
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.22A 3pghB-4r0sA:
undetectable		 3pghB-4r0sA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 141
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.09A 3rr3C-4r0sA:
undetectable		 3rr3C-4r0sA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 141
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.10A 3rr3D-4r0sA:
undetectable		 3rr3D-4r0sA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 144
TYR A 179
ARG A 181
ALA A 183
 None
 1.15A 3twpA-4r0sA:
undetectable		 3twpA-4r0sA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  56
VAL A 149
MET A 145
ARG A 147
ALA A 143
 None
 1.39A 5g44A-4r0sA:
undetectable		 5g44A-4r0sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  89
ILE A  47
SER A  59
 None
 0.77A 5gqbA-4r0sA:
undetectable		 5gqbA-4r0sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  83
ASP A  84
ARG A 138
 None
None
PO4  A 301 (-3.9A)
 1.02A 5jwaA-4r0sA:
undetectable
5jwaH-4r0sA:
undetectable		 5jwaA-4r0sA:
16.60
5jwaH-4r0sA:
16.60