SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 11 ALA A 286
LEU A 469
LEU A 198
GLY A 133
ALA A 200
 None
 1.14A 1b02A-4r0vA:
undetectable		 1b02A-4r0vA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 301
GLU A 141
ALA A 299
LEU A 313
 None
 1.04A 1eta1-4r0vA:
undetectable		 1eta1-4r0vA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 301
GLU A 141
ALA A 299
LEU A 313
 None
 1.02A 1etb1-4r0vA:
undetectable		 1etb1-4r0vA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.78A 1hsgB-4r0vA:
undetectable		 1hsgB-4r0vA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 4 SER A 189
PHE A 411
GLU A 144
GLY A 142
 None
 1.35A 1icvA-4r0vA:
undetectable
1icvB-4r0vA:
undetectable		 1icvA-4r0vA:
17.53
1icvB-4r0vA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.32A 1vidA-4r0vA:
undetectable		 1vidA-4r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		3 / 3 LEU A 145
LEU A 307
MET A 334
 None
 0.79A 1ya3B-4r0vA:
undetectable		 1ya3B-4r0vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 1.02A 1z11A-4r0vA:
undetectable		 1z11A-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 1.07A 1z11B-4r0vA:
undetectable		 1z11B-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 0.98A 1z11C-4r0vA:
undetectable		 1z11C-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 PHE A 124
ILE A 252
THR A 254
ILE A  99
LEU A 115
 None
 1.04A 1z11D-4r0vA:
undetectable		 1z11D-4r0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.84A 2avoB-4r0vA:
undetectable		 2avoB-4r0vA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.72A 2bpxB-4r0vA:
undetectable		 2bpxB-4r0vA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.31A 2cl5B-4r0vA:
undetectable		 2cl5B-4r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.83A 2o4sA-4r0vA:
undetectable		 2o4sA-4r0vA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A 160
GLU A 144
SER A 190
HIS A 482
 ARS  A 604 ( 4.8A)
None
None
None
 0.86A 2q0iA-4r0vA:
undetectable		 2q0iA-4r0vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.86A 2r5pB-4r0vA:
undetectable		 2r5pB-4r0vA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.32A 2zvjA-4r0vA:
undetectable		 2zvjA-4r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.82A 3el1B-4r0vA:
undetectable		 3el1B-4r0vA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.80A 3jvyA-4r0vA:
undetectable		 3jvyA-4r0vA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.75A 3oxcA-4r0vA:
undetectable		 3oxcA-4r0vA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 LEU A 131
ALA A  92
ASP A 129
TYR A 444
 None
 1.15A 3rodD-4r0vA:
undetectable		 3rodD-4r0vA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 THR A 330
LEU A 318
VAL A 388
VAL A 386
 None
 0.98A 4em2A-4r0vA:
undetectable		 4em2A-4r0vA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.31A 5fhrA-4r0vA:
undetectable		 5fhrA-4r0vA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		3 / 3 PRO A 428
ARG A 429
GLU A 101
 None
 0.94A 5j6hA-4r0vA:
undetectable		 5j6hA-4r0vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		3 / 3 LYS A 228
LYS A 192
SER A 193
 CSO  A 169 (-2.9A)
None
CL  A 603 ( 3.8A)
 1.19A 5odiA-4r0vA:
2.0		 5odiA-4r0vA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 122
VAL A 220
VAL A  95
THR A 110
GLU A 256
 None
 1.33A 5v1tA-4r0vA:
undetectable		 5v1tA-4r0vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4r0v FE-HYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 258
VAL A  91
GLY A 118
VAL A 220
ILE A 222
 None
 0.86A 6dj1A-4r0vA:
undetectable		 6dj1A-4r0vA:
10.71