SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 8 GLY A 165
ASN A 185
GLY A 166
VAL A 357
 None
 0.85A 1dbbH-4r0yA:
undetectable
1dbbL-4r0yA:
undetectable		 1dbbH-4r0yA:
19.42
1dbbL-4r0yA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.89A 1e06A-4r0yA:
undetectable		 1e06A-4r0yA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 4 ALA A 346
VAL A 343
ALA A 342
HIS A 809
 None
 1.18A 1q23A-4r0yA:
undetectable		 1q23A-4r0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 4 ALA A 346
VAL A 343
ALA A 342
HIS A 809
 None
 1.26A 1q23F-4r0yA:
undetectable		 1q23F-4r0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.09A 1wopA-4r0yA:
undetectable		 1wopA-4r0yA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 8 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.01A 2bfpD-4r0yA:
undetectable		 2bfpD-4r0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 11 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.15A 2f16H-4r0yA:
undetectable
2f16I-4r0yA:
undetectable		 2f16H-4r0yA:
21.98
2f16I-4r0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 11 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.16A 2f16V-4r0yA:
undetectable
2f16W-4r0yA:
undetectable		 2f16V-4r0yA:
21.98
2f16W-4r0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-4r0yA:
1.4		 2ve3A-4r0yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
 1.01A 3a51C-4r0yA:
undetectable		 3a51C-4r0yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.33A 3gv1A-4r0yA:
undetectable
3gv1C-4r0yA:
undetectable		 3gv1A-4r0yA:
15.37
3gv1C-4r0yA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.04A 3hs6A-4r0yA:
undetectable		 3hs6A-4r0yA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 7 GLU A 153
TYR A 155
MET A 330
TRP A 340
 None
 0.75A 3jyrA-4r0yA:
47.8		 3jyrA-4r0yA:
75.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 11 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.17A 3mg0H-4r0yA:
undetectable
3mg0I-4r0yA:
undetectable		 3mg0H-4r0yA:
21.98
3mg0I-4r0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.95A 3n8yB-4r0yA:
undetectable		 3n8yB-4r0yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.24A 3sj4X-4r0yA:
undetectable		 3sj4X-4r0yA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		6 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
PRO A 107
 None
 1.31A 3ufnA-4r0yA:
undetectable		 3ufnA-4r0yA:
12.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.79A 3vfjA-4r0yA:
54.0		 3vfjA-4r0yA:
75.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		3 / 3 LYS A 142
LEU A 139
ALA A 141
 None
 0.66A 4ikiA-4r0yA:
undetectable		 4ikiA-4r0yA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.93A 4n48A-4r0yA:
undetectable		 4n48A-4r0yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.88A 5f1aB-4r0yA:
undetectable		 5f1aB-4r0yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.19A 5l66H-4r0yA:
undetectable
5l66I-4r0yA:
undetectable		 5l66H-4r0yA:
21.41
5l66I-4r0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.20A 5l66V-4r0yA:
undetectable
5l66W-4r0yA:
undetectable		 5l66V-4r0yA:
21.41
5l66W-4r0yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1
(Escherichia
coli;
Rattus
norvegicus) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 None
 0.76A 6b58A-4r0yA:
5.0		 6b58A-4r0yA:
22.29