SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 6 LEU A 233
LEU A 210
LEU A 246
LEU A 165
 None
 0.83A 1errA-4r10A:
undetectable		 1errA-4r10A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 11 LEU A 229
ALA A 206
GLU A 208
ILE A 234
LEU A 191
 None
 1.23A 1g50A-4r10A:
undetectable		 1g50A-4r10A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 9 MET A 495
ARG A 399
ALA A 438
LEU A 440
GLY A 501
 None
 1.29A 1jb0A-4r10A:
undetectable		 1jb0A-4r10A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 5 ILE A 333
LEU A 336
ALA A 420
CYH A 418
 None
 0.82A 1mz9C-4r10A:
undetectable		 1mz9C-4r10A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 7 LEU A 425
ILE A 424
PHE A 421
ALA A 467
 None
 0.97A 1oniB-4r10A:
undetectable
1oniC-4r10A:
undetectable		 1oniB-4r10A:
13.62
1oniC-4r10A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r10 PROTEIN HUMPBACK-2
CADHERIN-RELATED
HMR-1
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 12 LEU B1189
GLU A 558
ASP B1199
ALA B1196
ALA A 403
 None
 1.09A 2br4F-4r10B:
undetectable		 2br4F-4r10B:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 232
LEU A 165
ALA A 166
ILE A 169
ALA A 203
 None
 0.58A 2bxpA-4r10A:
undetectable		 2bxpA-4r10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 10 ALA A 201
GLN A 224
SER A 197
LEU A 191
ASN A 189
 None
 1.31A 2ceoB-4r10A:
undetectable		 2ceoB-4r10A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 7 LEU A 246
PRO A 212
HIS A 213
GLY A 228
 None
 0.93A 2ddwB-4r10A:
undetectable		 2ddwB-4r10A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 5 LEU A 232
LEU A 165
ILE A 169
ALA A 203
 None
 0.50A 2i2zA-4r10A:
undetectable		 2i2zA-4r10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 ASN A 360
ARG A 404
ASP A 552
 None
 0.93A 2qe6A-4r10A:
undetectable		 2qe6A-4r10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 ASN A 360
ARG A 404
ASP A 552
 None
 0.91A 2qe6B-4r10A:
undetectable		 2qe6B-4r10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4r10 CADHERIN-RELATED
HMR-1
PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 MET A 495
VAL A 554
GLU B1200
 None
 0.80A 2x9gA-4r10A:
undetectable		 2x9gA-4r10A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 4 LEU A 335
ASP A 375
VAL A 368
THR A 358
 None
 1.26A 3cyxB-4r10A:
undetectable		 3cyxB-4r10A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 10 ILE A 443
ALA A 447
GLN A 508
LEU A 509
ILE A 436
 None
 1.04A 3falC-4r10A:
undetectable		 3falC-4r10A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 SER A 131
VAL A 179
ALA A 183
LEU A 187
LEU A 190
 None
 1.02A 3hs6A-4r10A:
0.6		 3hs6A-4r10A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 7 LEU A 312
ARG A 316
THR A 353
ALA A 350
 None
 1.21A 3mbgA-4r10A:
undetectable
3mbgB-4r10A:
undetectable		 3mbgA-4r10A:
12.59
3mbgB-4r10A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 ILE A 443
ALA A 447
GLN A 508
LEU A 509
ILE A 436
 None
 0.97A 3oapA-4r10A:
undetectable		 3oapA-4r10A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 9 MET A 495
ARG A 399
ALA A 438
LEU A 440
GLY A 501
 None
 1.29A 3pcqA-4r10A:
undetectable		 3pcqA-4r10A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 8 ALA A 206
LEU A 210
ASP A 236
SER A 239
 None
 1.00A 3qj7A-4r10A:
undetectable
3qj7D-4r10A:
undetectable		 3qj7A-4r10A:
20.52
3qj7D-4r10A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 ILE A 255
ALA A 226
LEU A 221
ILE A 251
THR A 268
 None
 1.25A 3ql3A-4r10A:
undetectable		 3ql3A-4r10A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 TYR A 182
ARG A 140
SER A 178
 None
 1.16A 4dr2I-4r10A:
undetectable
4dr2J-4r10A:
undetectable		 4dr2I-4r10A:
12.68
4dr2J-4r10A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 10 MET A 495
ARG A 399
ALA A 438
LEU A 440
GLY A 501
 None
 1.31A 4fe1A-4r10A:
undetectable
4fe1J-4r10A:
undetectable		 4fe1A-4r10A:
22.79
4fe1J-4r10A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 TYR A 182
ARG A 140
SER A 178
 None
 0.94A 4khpI-4r10A:
undetectable
4khpJ-4r10A:
undetectable		 4khpI-4r10A:
13.21
4khpJ-4r10A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		3 / 3 ARG A 271
ASP A 227
ARG A 306
 SEP  B1212 ( 4.2A)
None
SEP  B1212 ( 4.0A)
 0.82A 4mx0A-4r10A:
undetectable		 4mx0A-4r10A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		6 / 12 LEU A 535
LEU A 563
ILE A 559
LEU A 562
ILE A 479
ILE A 499
 None
 1.25A 4odrA-4r10A:
undetectable
4odrB-4r10A:
undetectable		 4odrA-4r10A:
10.37
4odrB-4r10A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 11 LEU A 428
VAL A 468
LEU A 506
LEU A 425
LEU A 440
 None
 1.21A 4or0B-4r10A:
3.0		 4or0B-4r10A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 11 LEU A 542
VAL A 503
LEU A 562
LEU A 547
LEU A 560
 None
 1.27A 4or0B-4r10A:
3.0		 4or0B-4r10A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 5 LYS A 437
ASP A 491
VAL A 493
GLU A 392
 None
 1.50A 4qzuA-4r10A:
0.0
4qzuD-4r10A:
undetectable		 4qzuA-4r10A:
12.06
4qzuD-4r10A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4r10 PROTEIN HUMPBACK-2
CADHERIN-RELATED
HMR-1
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 5 SER A 605
ARG A 609
LEU B1182
ASP B1179
 None
 1.26A 4xdtA-4r10A:
undetectable		 4xdtA-4r10A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 11 LEU A 318
ALA A 322
GLU A 325
LEU A 331
LEU A 328
 None
None
None
EDO  A1002 (-4.3A)
EDO  A1002 (-4.8A)
 1.27A 4zn7B-4r10A:
undetectable		 4zn7B-4r10A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 GLU A 500
GLY A 501
ILE A 436
ALA A 478
ALA A 502
 None
 1.01A 5kvaA-4r10A:
undetectable		 5kvaA-4r10A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 GLU A 500
GLY A 501
ILE A 436
ALA A 478
ALA A 502
 None
 1.04A 5kvaB-4r10A:
undetectable		 5kvaB-4r10A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 6 ARG A 557
GLY A 561
GLU A 558
SER A 504
 None
 1.08A 5ny7A-4r10A:
undetectable		 5ny7A-4r10A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		4 / 7 VAL A 468
HIS A 512
ILE A 454
THR A 466
 None
 1.05A 5vkqA-4r10A:
2.0
5vkqD-4r10A:
undetectable		 5vkqA-4r10A:
16.36
5vkqD-4r10A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4r10 PROTEIN HUMPBACK-2
(Caenorhabditis
elegans) 		5 / 12 VAL A 124
LEU A 127
ILE A 143
ILE A 159
VAL A  99
 None
 0.88A 6ajiA-4r10A:
undetectable		 6ajiA-4r10A:
22.48