SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 113
ALA A 147
ALA A 180
LEU A 183
ILE A  80
 None
 1.01A 1fk6A-4r16A:
undetectable		 1fk6A-4r16A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  55
LEU A  59
GLY A  28
ASN A  40
ALA A  16
 None
 1.15A 2bm9C-4r16A:
4.5		 2bm9C-4r16A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 253
THR A 372
GLU A 285
GLU A 335
 None
 1.05A 3fpjA-4r16A:
5.7		 3fpjA-4r16A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A   5
GLY A  28
ILE A  39
GLY A  12
 None
 0.75A 3n9jB-4r16A:
undetectable		 3n9jB-4r16A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 370
PHE A 408
LYS A 387
GLY A 386
 None
 0.98A 3sj0X-4r16A:
undetectable		 3sj0X-4r16A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 370
PHE A 408
LYS A 387
GLY A 386
 None
 1.01A 4hbfA-4r16A:
undetectable		 4hbfA-4r16A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 370
PHE A 408
LYS A 387
GLY A 386
 None
 0.96A 4hc3A-4r16A:
undetectable		 4hc3A-4r16A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 305
PRO A 306
SER A 307
 None
 0.40A 4k50I-4r16A:
undetectable		 4k50I-4r16A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 168
GLY A 170
ALA A 147
THR A 125
ILE A  80
 None
 0.96A 4r21B-4r16A:
undetectable		 4r21B-4r16A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 350
GLU A 376
TYR A 347
PHE A 377
 None
 1.37A 4twdA-4r16A:
undetectable
4twdB-4r16A:
undetectable		 4twdA-4r16A:
20.66
4twdB-4r16A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 350
GLU A 376
TYR A 347
PHE A 377
 None
 1.33A 4twdC-4r16A:
1.2
4twdD-4r16A:
1.2		 4twdC-4r16A:
20.66
4twdD-4r16A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 350
GLU A 376
TYR A 347
PHE A 377
 None
 1.40A 4twdF-4r16A:
undetectable
4twdG-4r16A:
undetectable		 4twdF-4r16A:
20.66
4twdG-4r16A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 331
VAL A 334
GLU A 335
ARG A 338
 None
 1.38A 4ww7A-4r16A:
undetectable		 4ww7A-4r16A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A   7
GLY A   9
PRO A  14
ARG A  99
GLU A 117
 None
 1.08A 4x61A-4r16A:
4.1		 4x61A-4r16A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  97
ILE A 120
PRO A  92
LEU A  94
 None
 0.80A 5g48A-4r16A:
undetectable		 5g48A-4r16A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 336
PHE A 333
VAL A 341
VAL A 344
LEU A 295
 None
 1.42A 5jkwA-4r16A:
undetectable		 5jkwA-4r16A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 311
PHE A 296
SER A 340
ALA A 309
 None
 1.06A 5msdA-4r16A:
3.3		 5msdA-4r16A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 333
ALA A 292
LEU A 299
ILE A 393
VAL A 341
 None
 1.04A 5uanB-4r16A:
undetectable		 5uanB-4r16A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 373
PHE A 377
ILE A 370
LEU A 314
PRO A 349
 None
 1.40A 6fgcA-4r16A:
undetectable		 6fgcA-4r16A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 PRO A 263
LEU A 266
VAL A 213
ARG A 281
 None
 1.41A 6fgdA-4r16A:
3.0		 6fgdA-4r16A:
22.75