SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 132
GLU A 148
ASP A 146
ARG A 155
 None
 1.10A 1dtlA-4r1jA:
undetectable		 1dtlA-4r1jA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 126
ASP A  10
PHE A  11
 None
 0.57A 1uwjB-4r1jA:
undetectable		 1uwjB-4r1jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 103
ASP A  34
ILE A  33
VAL A  64
 None
 0.89A 3fi0E-4r1jA:
undetectable		 3fi0E-4r1jA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 CYH A  45
ILE A  76
HIS A  22
LEU A  28
 None
 1.00A 3qpkA-4r1jA:
undetectable		 3qpkA-4r1jA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 165
TYR A  61
LEU A 140
 None
 0.75A 3sueB-4r1jA:
undetectable		 3sueB-4r1jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 141
LYS A 166
PRO A  97
GLU A 163
 None
 1.47A 4a7tF-4r1jA:
undetectable		 4a7tF-4r1jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4r1j GU4 NUCLEIC-BINDING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A   5
PRO A   6
SER A   7
 None
 0.41A 4k50I-4r1jA:
undetectable		 4k50I-4r1jA:
19.36