SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 VAL A 294
GLY A 291
LEU A 289
PHE A 304
GLU A 307
 None
None
None
None
MN  A 501 (-2.7A)
 1.35A 1iolA-4r1pA:
5.1		 1iolA-4r1pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		3 / 3 ASN A 406
PHE A 451
VAL A 408
 None
 0.83A 1kijA-4r1pA:
undetectable		 1kijA-4r1pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		3 / 3 GLU A 332
HIS A 349
HIS A 448
 MN  A 501 (-2.7A)
MN  A 501 (-3.6A)
MN  A 501 (-3.4A)
 0.50A 1oe2A-4r1pA:
undetectable		 1oe2A-4r1pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A  13
VAL A  36
CYH A  65
ARG A  63
 None
 1.04A 1t46A-4r1pA:
undetectable		 1t46A-4r1pA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 285
GLY A 213
LEU A 215
PRO A 290
ILE A 212
 None
 1.18A 2y7kD-4r1pA:
undetectable		 2y7kD-4r1pA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 5 VAL A 321
THR A 274
THR A 167
ARG A 166
 None
 1.23A 3bjwC-4r1pA:
undetectable		 3bjwC-4r1pA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 10 VAL A  13
VAL A  54
LEU A  25
SER A  53
GLY A  15
 None
 1.19A 3ls4H-4r1pA:
undetectable		 3ls4H-4r1pA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 403
ALA A 314
SER A 393
LEU A 318
TRP A 205
 None
 1.45A 3ou6D-4r1pA:
undetectable		 3ou6D-4r1pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 PHE A  51
GLY A  15
MET A  81
GLU A  60
ILE A  61
 None
 1.45A 3owxA-4r1pA:
4.0
3owxB-4r1pA:
3.8		 3owxA-4r1pA:
18.77
3owxB-4r1pA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 444
ILE A 404
VAL A 191
SER A 393
 None
 1.24A 4d33A-4r1pA:
undetectable		 4d33A-4r1pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 444
ILE A 404
VAL A 191
SER A 393
 None
 1.23A 4d33B-4r1pA:
undetectable		 4d33B-4r1pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 306
GLY A 308
ASN A 185
GLU A 352
 None
 1.30A 4fglC-4r1pA:
3.9		 4fglC-4r1pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.41A 4qvmV-4r1pA:
undetectable
4qvmb-4r1pA:
undetectable		 4qvmV-4r1pA:
19.68
4qvmb-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.41A 4qvmH-4r1pA:
undetectable
4qvmN-4r1pA:
undetectable		 4qvmH-4r1pA:
19.68
4qvmN-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.43A 4qvpV-4r1pA:
undetectable
4qvpb-4r1pA:
undetectable		 4qvpV-4r1pA:
19.68
4qvpb-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.44A 4qvqV-4r1pA:
undetectable
4qvqb-4r1pA:
undetectable		 4qvqV-4r1pA:
19.68
4qvqb-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.45A 4qvqH-4r1pA:
undetectable
4qvqN-4r1pA:
undetectable		 4qvqH-4r1pA:
19.68
4qvqN-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.39A 4qvwH-4r1pA:
undetectable
4qvwN-4r1pA:
undetectable		 4qvwH-4r1pA:
19.68
4qvwN-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.42A 4qw3V-4r1pA:
undetectable
4qw3b-4r1pA:
undetectable		 4qw3V-4r1pA:
19.68
4qw3b-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.42A 4qw3H-4r1pA:
undetectable
4qw3N-4r1pA:
undetectable		 4qw3H-4r1pA:
19.68
4qw3N-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.44A 4qwuV-4r1pA:
undetectable
4qwub-4r1pA:
undetectable		 4qwuV-4r1pA:
19.68
4qwub-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.45A 4qwuH-4r1pA:
undetectable
4qwuN-4r1pA:
undetectable		 4qwuH-4r1pA:
19.68
4qwuN-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 244
ARG A 251
GLY A 248
GLU A 247
 None
 0.92A 4z2eB-4r1pA:
undetectable
4z2eC-4r1pA:
2.4		 4z2eB-4r1pA:
24.96
4z2eC-4r1pA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 6 GLN A 295
PHE A 304
PHE A 276
LEU A 264
 None
 1.17A 5b1bC-4r1pA:
undetectable
5b1bJ-4r1pA:
undetectable		 5b1bC-4r1pA:
19.32
5b1bJ-4r1pA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.37A 5bxnV-4r1pA:
undetectable
5bxnb-4r1pA:
undetectable		 5bxnV-4r1pA:
19.68
5bxnb-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.43A 5cz7H-4r1pA:
undetectable
5cz7N-4r1pA:
undetectable		 5cz7H-4r1pA:
19.68
5cz7N-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.39A 5d0xV-4r1pA:
undetectable
5d0xb-4r1pA:
undetectable		 5d0xV-4r1pA:
19.68
5d0xb-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_A_ACTA1229_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 4 VAL A 189
GLU A 281
THR A 279
GLU A 307
 None
None
None
MN  A 501 (-2.7A)
 1.44A 5g5hA-4r1pA:
0.0		 5g5hA-4r1pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 8 GLN A 126
ALA A  24
HIS A  31
HIS A  82
 None
 0.83A 5km8A-4r1pA:
undetectable
5km8B-4r1pA:
undetectable		 5km8A-4r1pA:
15.38
5km8B-4r1pA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.39A 5l66V-4r1pA:
undetectable
5l66b-4r1pA:
undetectable		 5l66V-4r1pA:
19.68
5l66b-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 448
THR A 277
THR A 278
GLY A 303
ALA A 313
 MN  A 501 (-3.4A)
None
None
None
None
 1.39A 5l66H-4r1pA:
undetectable
5l66N-4r1pA:
undetectable		 5l66H-4r1pA:
19.68
5l66N-4r1pA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 303
PHE A 276
LEU A 351
PHE A 304
THR A 278
 None
 1.30A 5nknA-4r1pA:
undetectable		 5nknA-4r1pA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		5 / 12 PHE A 203
ALA A 454
ALA A 389
ILE A 404
LEU A 460
 None
 1.03A 6aybA-4r1pA:
undetectable		 6aybA-4r1pA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 4 LEU A 426
ASP A 383
PRO A 413
ARG A 424
 None
 1.38A 6fgdA-4r1pA:
5.7		 6fgdA-4r1pA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4r1p L-ARABINOSE
ISOMERASE
(Geobacillus
kaustophilus) 		4 / 8 TYR A 234
ALA A 293
VAL A 294
ARG A 296
 None
 0.68A 6hu9a-4r1pA:
undetectable
6hu9e-4r1pA:
undetectable		 6hu9a-4r1pA:
20.00
6hu9e-4r1pA:
14.69