SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 9 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.92A 1hxwA-4r1uA:
undetectable		 1hxwA-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 11 PRO A 265
LEU A 264
ASN A 192
VAL A 181
TYR A 216
 None
 1.34A 1mrlA-4r1uA:
undetectable
1mrlB-4r1uA:
undetectable		 1mrlA-4r1uA:
19.89
1mrlB-4r1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 PRO A 265
LEU A 264
ASN A 192
VAL A 181
TYR A 216
 None
 1.33A 1mrlB-4r1uA:
undetectable
1mrlC-4r1uA:
undetectable		 1mrlB-4r1uA:
19.89
1mrlC-4r1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.85A 1muiB-4r1uA:
undetectable		 1muiB-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		3 / 3 PRO A 295
ASP A 221
ASP A 302
 None
 0.79A 1sqfA-4r1uA:
5.7		 1sqfA-4r1uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 TYR A 152
ALA A 159
GLY A 155
ALA A 163
PHE A 115
 None
 1.20A 1ve3A-4r1uA:
5.9		 1ve3A-4r1uA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 1.01A 2hs2A-4r1uA:
undetectable		 2hs2A-4r1uA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.85A 2hs2B-4r1uA:
undetectable		 2hs2B-4r1uA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.89A 2o4sA-4r1uA:
undetectable		 2o4sA-4r1uA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.87A 2z54A-4r1uA:
undetectable		 2z54A-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.90A 2z54B-4r1uA:
undetectable		 2z54B-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.92A 3cywB-4r1uA:
undetectable		 3cywB-4r1uA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.86A 3d1xB-4r1uA:
undetectable		 3d1xB-4r1uA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.86A 3d20A-4r1uA:
undetectable		 3d20A-4r1uA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.93A 3d20B-4r1uA:
undetectable		 3d20B-4r1uA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 10 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.91A 3em3A-4r1uA:
undetectable		 3em3A-4r1uA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.87A 3lzsA-4r1uA:
undetectable		 3lzsA-4r1uA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.91A 3lzsB-4r1uA:
undetectable		 3lzsB-4r1uA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.84A 3ndwA-4r1uA:
undetectable		 3ndwA-4r1uA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.89A 3pwmA-4r1uA:
undetectable		 3pwmA-4r1uA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.91A 3tkwA-4r1uA:
undetectable		 3tkwA-4r1uA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		4 / 8 SER A 118
ASN A 178
ARG A 238
GLY A 155
 None
 1.03A 4af0A-4r1uA:
undetectable		 4af0A-4r1uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.91A 4hlaA-4r1uA:
undetectable		 4hlaA-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 11 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.89A 4hlaB-4r1uA:
undetectable		 4hlaB-4r1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		4 / 7 LEU A 142
TRP A 139
VAL A 176
SER A 117
 None
 1.17A 5umwA-4r1uA:
undetectable
5umwF-4r1uA:
undetectable		 5umwA-4r1uA:
13.89
5umwF-4r1uA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 THR A 121
VAL A 122
SER A 118
ASN A 178
THR A   7
 None
 1.49A 5v1tA-4r1uA:
undetectable		 5v1tA-4r1uA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4r1u CINNAMOYL COA
REDUCTASE
(Medicago
truncatula) 		5 / 12 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
 None
 0.90A 6dgxA-4r1uA:
undetectable		 6dgxA-4r1uA:
10.29