SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 9 LEU A 118
ALA A 126
GLY A 312
ALA A 313
THR A 317
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
 1.07A 1nr6A-4r1zA:
44.1		 1nr6A-4r1zA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ARG A 273
SER A 199
PHE A 197
LEU A 256
LEU A 280
 None
 1.47A 1p33C-4r1zA:
undetectable		 1p33C-4r1zA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		3 / 3 ARG A 402
VAL A 222
THR A 114
 None
 0.73A 3cyxA-4r1zA:
undetectable		 3cyxA-4r1zA:
11.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		3 / 3 ALA A 313
THR A 317
CYH A 453
 HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-2.3A)
 0.68A 3e4eA-4r1zA:
42.4		 3e4eA-4r1zA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		3 / 3 ALA A 313
THR A 317
CYH A 453
 HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-2.3A)
 0.61A 3e4eB-4r1zA:
42.2		 3e4eB-4r1zA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		3 / 3 ASN A  90
HIS A  94
VAL A 392
 None
 0.82A 3elzB-4r1zA:
undetectable		 3elzB-4r1zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 7 THR A 320
GLU A 316
VAL A 315
THR A 319
VAL A 188
 None
 1.40A 3em0B-4r1zA:
undetectable		 3em0B-4r1zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 LEU A 298
SER A 285
LEU A 279
ASP A 277
ASP A 269
 None
 1.25A 3ko0A-4r1zA:
undetectable
3ko0B-4r1zA:
undetectable
3ko0C-4r1zA:
undetectable
3ko0D-4r1zA:
undetectable		 3ko0A-4r1zA:
14.25
3ko0B-4r1zA:
14.25
3ko0C-4r1zA:
14.25
3ko0D-4r1zA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 LEU A 279
ASP A 277
LEU A 298
SER A 285
ASP A 269
 None
 1.26A 3ko0K-4r1zA:
undetectable
3ko0L-4r1zA:
undetectable
3ko0M-4r1zA:
undetectable
3ko0N-4r1zA:
undetectable		 3ko0K-4r1zA:
14.25
3ko0L-4r1zA:
14.25
3ko0M-4r1zA:
14.25
3ko0N-4r1zA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 10 LEU A 364
SER A 325
ILE A 339
PHE A 428
PHE A 423
 None
 1.46A 3m0wE-4r1zA:
0.0
3m0wF-4r1zA:
0.1
3m0wG-4r1zA:
0.0
3m0wH-4r1zA:
undetectable		 3m0wE-4r1zA:
14.50
3m0wF-4r1zA:
14.50
3m0wG-4r1zA:
14.50
3m0wH-4r1zA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 12 ALA A 126
PHE A 127
ASP A 309
ALA A 313
THR A 317
VAL A 494
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.1A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 1.48A 3rukA-4r1zA:
50.7		 3rukA-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 ALA A 126
PHE A 127
TYR A 214
ILE A 218
ASP A 309
ALA A 313
THR A 317
VAL A 377
CYH A 453
 HEM  A 600 (-3.6A)
None
AER  A 601 (-4.7A)
AER  A 601 ( 4.3A)
AER  A 601 ( 4.1A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-4.6A)
HEM  A 600 (-2.3A)
 0.65A 3rukA-4r1zA:
50.7		 3rukA-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 ALA A 126
TYR A 214
ILE A 218
ASP A 309
ALA A 313
THR A 317
VAL A 377
CYH A 453
VAL A 493
 HEM  A 600 (-3.6A)
AER  A 601 (-4.7A)
AER  A 601 ( 4.3A)
AER  A 601 ( 4.1A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-4.6A)
HEM  A 600 (-2.3A)
None
 0.64A 3rukA-4r1zA:
50.7		 3rukA-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 ALA A 126
ILE A 218
ASP A 309
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 4.1A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.64A 3rukB-4r1zA:
51.1		 3rukB-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 12 ALA A 126
PHE A 127
ASP A 309
ALA A 313
THR A 317
VAL A 494
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.1A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 0.64A 3rukB-4r1zA:
51.1		 3rukB-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 9 ALA A 126
PHE A 127
ILE A 218
ARG A 252
ASP A 124
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
None
None
 1.31A 3rukC-4r1zA:
50.6		 3rukC-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 9 ALA A 126
PHE A 127
TYR A 214
ILE A 218
ARG A 252
ASP A 309
GLU A 316
THR A 317
 HEM  A 600 (-3.6A)
None
AER  A 601 (-4.7A)
AER  A 601 ( 4.3A)
None
AER  A 601 ( 4.1A)
None
HEM  A 600 ( 3.3A)
 0.73A 3rukC-4r1zA:
50.6		 3rukC-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 11 ALA A 126
PHE A 127
ASP A 309
ALA A 313
THR A 317
VAL A 494
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.1A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 1.43A 3rukD-4r1zA:
51.0		 3rukD-4r1zA:
46.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		10 / 11 ALA A 126
PHE A 127
TYR A 214
ILE A 218
ARG A 252
ASP A 309
GLY A 312
ALA A 313
THR A 317
VAL A 377
 HEM  A 600 (-3.6A)
None
AER  A 601 (-4.7A)
AER  A 601 ( 4.3A)
None
AER  A 601 ( 4.1A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-4.6A)
 0.57A 3rukD-4r1zA:
51.0		 3rukD-4r1zA:
46.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 8 ALA A 126
PHE A 127
ALA A 313
THR A 317
 HEM  A 600 (-3.6A)
None
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
 0.72A 3t3sD-4r1zA:
42.4		 3t3sD-4r1zA:
29.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.52A 4nkvA-4r1zA:
51.1		 4nkvA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 0.52A 4nkvA-4r1zA:
51.1		 4nkvA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 5 TYR A 214
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 (-4.7A)
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.72A 4nkvA-4r1zA:
51.1		 4nkvA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.53A 4nkvB-4r1zA:
51.1		 4nkvB-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 0.53A 4nkvB-4r1zA:
51.1		 4nkvB-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 5 TYR A 214
ARG A 252
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 (-4.7A)
None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.80A 4nkvB-4r1zA:
51.1		 4nkvB-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.57A 4nkvC-4r1zA:
51.4		 4nkvC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 0.55A 4nkvC-4r1zA:
51.4		 4nkvC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.56A 4nkvD-4r1zA:
51.7		 4nkvD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 0.53A 4nkvD-4r1zA:
51.7		 4nkvD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 5 TYR A 214
GLY A 308
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 (-4.7A)
None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.73A 4nkvD-4r1zA:
51.7		 4nkvD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ALA A 126
GLY A 312
ALA A 313
ILE A 382
VAL A 493
 HEM  A 600 (-3.6A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 4.1A)
None
 1.01A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ALA A 126
ILE A 218
GLY A 312
ALA A 313
ILE A 382
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 4.1A)
 1.06A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
ILE A 382
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
None
 0.40A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.58A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
THR A 317
ILE A 382
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
 0.58A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 6 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.85A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 5 ILE A 218
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 ( 4.3A)
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.74A 4nkxB-4r1zA:
50.9		 4nkxB-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ALA A 126
GLY A 312
ALA A 313
ILE A 382
VAL A 493
 HEM  A 600 (-3.6A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 4.1A)
None
 1.01A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
ILE A 382
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
None
 0.46A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.63A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		7 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
THR A 317
ILE A 382
VAL A 494
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
None
 0.65A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 5 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.87A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ALA A 126
GLY A 312
ALA A 313
ILE A 382
VAL A 493
 HEM  A 600 (-3.6A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 4.1A)
None
 0.99A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
ILE A 382
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
None
 0.46A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
None
 0.61A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
THR A 317
ILE A 382
 None
HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
 0.63A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 5 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.77A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 LEU A 471
LEU A 467
LEU A 180
VAL A 330
MET A 166
 None
 1.25A 4olmA-4r1zA:
2.0		 4olmA-4r1zA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 8 ALA A 126
ILE A 218
GLY A 312
THR A 317
VAL A 377
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
AER  A 601 ( 3.7A)
HEM  A 600 ( 3.3A)
HEM  A 600 (-4.6A)
 0.78A 4r20A-4r1zA:
50.0		 4r20A-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 8 ALA A 126
ILE A 218
THR A 317
SER A 378
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.6A)
 0.70A 4r20A-4r1zA:
50.0		 4r20A-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		8 / 9 ALA A 126
PHE A 127
ILE A 218
VAL A 219
GLY A 312
THR A 317
SER A 378
VAL A 493
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 4.3A)
None
AER  A 601 ( 3.7A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.6A)
None
 0.88A 4r20B-4r1zA:
49.2		 4r20B-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 6 ALA A 126
ILE A 218
SER A 378
ILE A 382
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
HEM  A 600 ( 4.6A)
HEM  A 600 ( 4.1A)
 0.79A 4r21A-4r1zA:
49.0		 4r21A-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		7 / 9 ALA A 126
ILE A 218
VAL A 219
ALA A 313
THR A 317
SER A 378
ILE A 382
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
None
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.6A)
HEM  A 600 ( 4.1A)
 1.00A 4r21B-4r1zA:
49.1		 4r21B-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		7 / 9 ALA A 126
ILE A 218
VAL A 219
ALA A 313
THR A 317
SER A 378
VAL A 493
 HEM  A 600 (-3.6A)
AER  A 601 ( 4.3A)
None
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.6A)
None
 1.09A 4r21B-4r1zA:
49.1		 4r21B-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 9 ALA A 126
VAL A 219
GLY A 312
ALA A 313
THR A 317
ILE A 382
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
HEM  A 600 ( 4.1A)
 1.16A 4r21B-4r1zA:
49.1		 4r21B-4r1zA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		6 / 9 ALA A 126
VAL A 219
GLY A 312
ALA A 313
THR A 317
VAL A 493
 HEM  A 600 (-3.6A)
None
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
None
 1.21A 4r21B-4r1zA:
49.1		 4r21B-4r1zA:
46.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 4 LEU A 279
ILE A 125
HIS A 137
VAL A 141
 None
HEM  A 600 ( 4.5A)
None
None
 1.08A 4xyzA-4r1zA:
undetectable		 4xyzA-4r1zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 5 TYR A 328
LEU A 495
PRO A 497
LEU A 372
 None
 1.25A 5eshA-4r1zA:
33.1		 5eshA-4r1zA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 7 VAL A 493
LEU A 118
THR A 115
THR A 114
 None
 0.93A 5m78A-4r1zA:
undetectable		 5m78A-4r1zA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		3 / 3 ASN A 406
VAL A 392
HIS A  94
 None
 0.77A 6a5yD-4r1zA:
undetectable		 6a5yD-4r1zA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 ILE A 125
VAL A  89
LEU A 410
GLY A 455
ARG A 451
 HEM  A 600 ( 4.5A)
None
None
HEM  A 600 (-3.6A)
HEM  A 600 (-3.9A)
 1.13A 6a7pA-4r1zA:
undetectable		 6a7pA-4r1zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		4 / 4 ILE A 125
LEU A 275
HIS A 142
ALA A 144
 HEM  A 600 ( 4.5A)
None
None
None
 1.04A 6ck2C-4r1zA:
undetectable
6ck2D-4r1zA:
undetectable		 6ck2C-4r1zA:
8.33
6ck2D-4r1zA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 9 LEU A 212
SER A 210
PHE A 208
GLU A 207
ASN A 190
 None
 1.44A 6ftpA-4r1zA:
undetectable
6ftpB-4r1zA:
undetectable		 6ftpA-4r1zA:
11.31
6ftpB-4r1zA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4r1z CYP17A1 PROTEIN
(Danio
rerio) 		5 / 12 GLY A 181
LEU A 184
GLY A 312
GLN A 496
PRO A 497
 None
None
AER  A 601 ( 3.7A)
None
None
 1.05A 6gngB-4r1zA:
undetectable		 6gngB-4r1zA:
21.88