SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 9 LEU A 112
ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
 AER  A 602 ( 4.8A)
AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
 1.31A 1nr6A-4r20A:
43.7		 1nr6A-4r20A:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 VAL A 439
PHE A 417
CYH A 358
HIS A 400
ILE A  86
 None
 1.22A 1skxA-4r20A:
undetectable		 1skxA-4r20A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 11 HIS A 400
ILE A 363
PRO A 365
VAL A 366
PHE A 430
 None
None
None
AER  A 602 ( 4.9A)
None
 1.15A 1wu8B-4r20A:
0.0
1wu8C-4r20A:
0.0		 1wu8B-4r20A:
19.26
1wu8C-4r20A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		4 / 4 GLY A 382
SER A 380
VAL A  92
LEU A  70
 None
 1.28A 1yajB-4r20A:
undetectable		 1yajB-4r20A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		4 / 6 LEU A 370
GLY A 434
ILE A 399
HIS A 400
 HEM  A 601 ( 4.1A)
HEM  A 601 (-4.0A)
None
None
 0.90A 1yajF-4r20A:
undetectable		 1yajF-4r20A:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		3 / 3 ALA A 302
THR A 306
CYH A 440
 HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 (-2.2A)
 0.61A 3e4eA-4r20A:
42.0		 3e4eA-4r20A:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		3 / 3 ALA A 302
THR A 306
CYH A 440
 HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 (-2.2A)
 0.55A 3e4eB-4r20A:
42.1		 3e4eB-4r20A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		4 / 4 LEU A  70
PRO A  69
LEU A  88
ARG A  96
 None
 1.17A 3hcoB-4r20A:
undetectable		 3hcoB-4r20A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		4 / 8 VAL A 304
GLY A 301
ARG A 246
ILE A 212
 None
AER  A 602 ( 3.8A)
None
AER  A 602 (-3.2A)
 0.70A 3n9jB-4r20A:
undetectable		 3n9jB-4r20A:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
ILE A 216
THR A 306
VAL A 366
CYH A 440
 AER  A 602 (-3.7A)
None
None
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
HEM  A 601 (-2.2A)
 1.30A 3rukA-4r20A:
49.4		 3rukA-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 ALA A 120
PHE A 121
TYR A 208
ASN A 209
ILE A 212
ALA A 302
THR A 306
VAL A 366
CYH A 440
 AER  A 602 (-3.7A)
None
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
HEM  A 601 (-2.2A)
 0.73A 3rukA-4r20A:
49.4		 3rukA-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		8 / 12 TYR A 208
ASN A 209
ILE A 212
ALA A 302
THR A 306
VAL A 366
CYH A 440
VAL A 480
 None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
HEM  A 601 (-2.2A)
AER  A 602 ( 4.9A)
 0.83A 3rukA-4r20A:
49.4		 3rukA-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 TYR A 208
ASN A 209
ILE A 212
LEU A 112
ALA A 302
THR A 306
CYH A 440
 None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 4.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 (-2.2A)
 1.41A 3rukA-4r20A:
49.4		 3rukA-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
ASN A 209
GLY A 301
ALA A 302
THR A 306
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
 0.74A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.58A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ASN A 209
ILE A 212
ALA A 302
THR A 306
VAL A 480
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 0.66A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ASN A 209
ILE A 212
GLY A 301
ALA A 302
THR A 306
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
 0.63A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ILE A 212
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.75A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ILE A 212
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.51A 3rukB-4r20A:
49.6		 3rukB-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 9 ALA A 120
PHE A 121
ASN A 209
ILE A 212
ARG A 246
THR A 306
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 ( 3.3A)
 0.84A 3rukC-4r20A:
49.2		 3rukC-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 9 ALA A 120
PHE A 121
ILE A 212
ARG A 246
GLU A 305
THR A 306
 AER  A 602 (-3.7A)
None
AER  A 602 (-3.2A)
None
None
HEM  A 601 ( 3.3A)
 0.94A 3rukC-4r20A:
49.2		 3rukC-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 9 ALA A 120
PHE A 121
ILE A 216
GLU A 305
THR A 306
 AER  A 602 (-3.7A)
None
None
None
HEM  A 601 ( 3.3A)
 1.05A 3rukC-4r20A:
49.2		 3rukC-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 9 TYR A 208
ASN A 209
ILE A 212
ARG A 246
THR A 306
 None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 ( 3.3A)
 0.67A 3rukC-4r20A:
49.2		 3rukC-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 11 ALA A 120
PHE A 121
ILE A 216
THR A 306
VAL A 366
 AER  A 602 (-3.7A)
None
None
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 1.21A 3rukD-4r20A:
49.4		 3rukD-4r20A:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		10 / 11 ALA A 120
PHE A 121
TYR A 208
ASN A 209
ILE A 212
ARG A 246
GLY A 301
ALA A 302
THR A 306
VAL A 366
 AER  A 602 (-3.7A)
None
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 0.80A 3rukD-4r20A:
49.4		 3rukD-4r20A:
43.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ALA A 355
ASP A 354
VAL A 454
LEU A 311
LEU A 450
 None
 1.21A 3s79A-4r20A:
38.0		 3s79A-4r20A:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		4 / 8 ALA A 120
PHE A 121
ALA A 302
THR A 306
 AER  A 602 (-3.7A)
None
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
 0.55A 3t3sD-4r20A:
41.8		 3t3sD-4r20A:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ALA A 446
GLU A 449
LEU A 189
LEU A 269
HIS A 136
 HEM  A 601 (-3.4A)
None
None
None
None
 1.11A 4j24D-4r20A:
undetectable		 4j24D-4r20A:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 ALA A 120
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.65A 4nkvA-4r20A:
49.9		 4nkvA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 ASN A 209
ILE A 212
ARG A 246
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.67A 4nkvA-4r20A:
49.9		 4nkvA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 LEU A 112
ASN A 209
ILE A 212
ARG A 246
THR A 306
VAL A 480
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.88A 4nkvA-4r20A:
49.9		 4nkvA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		8 / 12 LEU A 112
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
THR A 306
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 ( 3.3A)
None
 0.81A 4nkvA-4r20A:
49.9		 4nkvA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		8 / 12 ALA A 120
PHE A 121
ASN A 209
ILE A 212
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.66A 4nkvB-4r20A:
49.6		 4nkvB-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ASN A 209
ILE A 212
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.72A 4nkvB-4r20A:
49.6		 4nkvB-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
ASN A 209
ILE A 212
THR A 306
VAL A 480
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.94A 4nkvB-4r20A:
49.6		 4nkvB-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 LEU A 112
PHE A 121
ASN A 209
ILE A 212
GLY A 301
THR A 306
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 ( 3.3A)
None
 0.85A 4nkvB-4r20A:
49.6		 4nkvB-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 ALA A 120
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.67A 4nkvC-4r20A:
49.8		 4nkvC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		8 / 12 LEU A 112
ASN A 209
ILE A 212
ARG A 246
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.91A 4nkvC-4r20A:
49.8		 4nkvC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 LEU A 112
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.78A 4nkvC-4r20A:
49.8		 4nkvC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 ALA A 120
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
ALA A 302
THR A 306
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
None
 0.67A 4nkvD-4r20A:
50.2		 4nkvD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 ASN A 209
ILE A 212
ARG A 246
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.76A 4nkvD-4r20A:
50.2		 4nkvD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 12 LEU A 112
ALA A 120
PHE A 121
ASN A 209
ILE A 212
ARG A 246
GLY A 301
THR A 306
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-3.7A)
None
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 ( 3.3A)
None
 0.81A 4nkvD-4r20A:
50.2		 4nkvD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 LEU A 112
ASN A 209
ILE A 212
ARG A 246
THR A 306
VAL A 480
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
None
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.96A 4nkvD-4r20A:
50.2		 4nkvD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
ASN A 209
GLY A 301
ALA A 302
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
AER  A 602 (-4.5A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 1.07A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		8 / 12 ALA A 120
ASN A 209
ILE A 212
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 (-3.7A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.65A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.96A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.52A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ASN A 209
ILE A 212
ALA A 302
THR A 306
VAL A 480
VAL A 481
 AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
None
 0.79A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
ILE A 212
GLY A 301
THR A 306
ILE A 371
VAL A 481
 AER  A 602 ( 4.8A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.80A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
PHE A 121
GLY A 301
THR A 306
ILE A 371
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 ( 3.8A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.70A 4nkxA-4r20A:
49.2		 4nkxA-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
ASN A 209
GLY A 301
ALA A 302
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
AER  A 602 (-4.5A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 1.05A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.90A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.48A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 LEU A 112
ASN A 209
ILE A 212
ALA A 302
VAL A 480
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
AER  A 602 ( 4.9A)
 0.81A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
ASN A 209
ILE A 212
GLY A 301
ALA A 302
ILE A 371
 AER  A 602 ( 4.8A)
AER  A 602 (-4.5A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
 0.86A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 LEU A 112
ILE A 212
ALA A 302
THR A 306
VAL A 480
 AER  A 602 ( 4.8A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 0.98A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
ILE A 212
GLY A 301
ALA A 302
THR A 306
ILE A 371
 AER  A 602 ( 4.8A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
 0.84A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 LEU A 112
PHE A 121
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.67A 4nkxC-4r20A:
49.3		 4nkxC-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.89A 4nkxD-4r20A:
49.2		 4nkxD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.52A 4nkxD-4r20A:
49.2		 4nkxD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 LEU A 112
ILE A 212
ALA A 302
THR A 306
VAL A 480
 AER  A 602 ( 4.8A)
AER  A 602 (-3.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 0.94A 4nkxD-4r20A:
49.2		 4nkxD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 12 LEU A 112
ILE A 212
GLY A 301
ALA A 302
THR A 306
ILE A 371
 AER  A 602 ( 4.8A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
 0.84A 4nkxD-4r20A:
49.2		 4nkxD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 12 LEU A 112
PHE A 121
GLY A 301
ALA A 302
THR A 306
ILE A 371
VAL A 481
 AER  A 602 ( 4.8A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
HEM  A 601 ( 4.9A)
None
 0.67A 4nkxD-4r20A:
49.2		 4nkxD-4r20A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		7 / 9 ALA A 120
TYR A 208
ILE A 212
GLY A 301
ALA A 302
THR A 306
VAL A 480
 AER  A 602 (-3.7A)
None
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 ( 4.9A)
 0.74A 4r1zA-4r20A:
24.7		 4r1zA-4r20A:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 7 ALA A 120
GLY A 301
ALA A 302
GLU A 305
THR A 306
SER A 367
 AER  A 602 (-3.7A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
None
HEM  A 601 ( 3.3A)
AER  A 602 (-3.5A)
 0.50A 4r1zB-4r20A:
50.3		 4r1zB-4r20A:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		6 / 6 ALA A 120
ILE A 212
GLY A 301
SER A 367
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
AER  A 602 (-3.2A)
AER  A 602 ( 3.8A)
AER  A 602 (-3.5A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.78A 4r21A-4r20A:
58.8		 4r21A-4r20A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 9 ALA A 120
GLY A 301
ALA A 302
ILE A 371
VAL A 481
 AER  A 602 (-3.7A)
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.9A)
None
 0.99A 4r21B-4r20A:
59.5		 4r21B-4r20A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		9 / 9 ALA A 120
ILE A 212
VAL A 213
GLY A 301
ALA A 302
THR A 306
SER A 367
ILE A 371
VAL A 480
 AER  A 602 (-3.7A)
AER  A 602 (-3.2A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
AER  A 602 (-3.5A)
HEM  A 601 ( 4.9A)
AER  A 602 ( 4.9A)
 0.76A 4r21B-4r20A:
59.5		 4r21B-4r20A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		3 / 3 ARG A 246
GLU A 305
TYR A 208
 None
 0.88A 4r29D-4r20A:
undetectable		 4r29D-4r20A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 ALA A 355
ASP A 354
VAL A 454
LEU A 311
LEU A 450
 None
 1.20A 5jkvA-4r20A:
38.0		 5jkvA-4r20A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2
(Danio
rerio) 		5 / 12 LEU A 250
ILE A 245
THR A 215
THR A 204
LEU A 202
 None
 1.21A 6djzB-4r20A:
undetectable		 6djzB-4r20A:
19.49