SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VIF_A_FOLA1_0 (DIHYDROFOLATE REDUCTASE)	4r22	HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA (Bacillus megaterium)	3 / 3	GLN B 29 ILE B 30 TYR B 33	None	0.76A	1vifA-4r22B: undetectable	1vifA-4r22B: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_2 (DIPEPTIDYL PEPTIDASE IV)	4r22	HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA (Bacillus megaterium)	3 / 3	ARG B 76 SER B 52 TYR B 51	None	0.78A	1x70A-4r22B: undetectable	1x70A-4r22B: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_MTLA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	4r22	HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA (Bacillus megaterium)	4 / 6	GLU B 57 ASP B 61 ASP B 64 ARG B 65	None	1.33A	4kcnA-4r22B: undetectable	4kcnA-4r22B: 11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	4r22	HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA (Bacillus megaterium)	4 / 6	GLU B 57 ASP B 61 ASP B 64 ARG B 65	None	1.33A	4kcnB-4r22B: undetectable	4kcnB-4r22B: 11.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1VIF_A_FOLA1_0","DIHYDROFOLATE REDUCTASE","4r22","HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA","Bacillus megaterium",3,"GLN B  29;ILE B  30;TYR B  33","None","0.76A","1vifA-4r22B:undetectable","1vifA-4r22B:21.43"],["1X70_A_715A801_2","DIPEPTIDYL PEPTIDASE IV","4r22","HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA","Bacillus megaterium",3,"ARG B  76;SER B  52;TYR B  51","None","0.78A","1x70A-4r22B:undetectable","1x70A-4r22B:9.52"],["4KCN_A_MTLA804_0","NITRIC OXIDE SYNTHASE, BRAIN","4r22","HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA","Bacillus megaterium",4,"GLU B  57;ASP B  61;ASP B  64;ARG B  65","None","1.33A","4kcnA-4r22B:undetectable","4kcnA-4r22B:11.37"],["4KCN_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","4r22","HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA","Bacillus megaterium",4,"GLU B  57;ASP B  61;ASP B  64;ARG B  65","None","1.33A","4kcnB-4r22B:undetectable","4kcnB-4r22B:11.37"]]