SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 6 TYR A  34
TYR A 118
ILE A  26
ILE A  30
 None
 1.22A 2dcfA-4r29A:
undetectable		 2dcfA-4r29A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 105
ASP A 121
PHE A  84
THR A 101
ILE A  87
 None
 1.11A 3prsA-4r29A:
undetectable		 3prsA-4r29A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 ASP A  43
TYR A 118
SER A 116
ASN A 119
TYR A  34
 None
 1.31A 4dajA-4r29A:
undetectable		 4dajA-4r29A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 ASP A  43
TYR A 118
SER A 116
ASN A 119
TYR A  34
 None
 1.08A 4dajC-4r29A:
1.3		 4dajC-4r29A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 204
ARG A 107
SER A 203
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.7A)
None
 1.10A 4dr2I-4r29A:
undetectable
4dr2J-4r29A:
undetectable		 4dr2I-4r29A:
19.38
4dr2J-4r29A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 GLN A 111
VAL A 147
ILE A 135
TYR A  27
ILE A  30
 GOL  A 302 ( 4.0A)
None
None
None
None
 1.35A 4drhA-4r29A:
undetectable		 4drhA-4r29A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 146
LEU A  57
TYR A  34
LEU A 122
HIS A 123
 None
 1.25A 4j03A-4r29A:
undetectable		 4j03A-4r29A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 204
ARG A 107
SER A 203
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.7A)
None
 1.12A 4lf7I-4r29A:
undetectable
4lf7J-4r29A:
0.6		 4lf7I-4r29A:
19.38
4lf7J-4r29A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 204
ARG A 107
SER A 203
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.7A)
None
 1.12A 4lf8I-4r29A:
undetectable
4lf8J-4r29A:
0.6		 4lf8I-4r29A:
19.38
4lf8J-4r29A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		3 / 3 ILE A 165
MET A 109
ARG A 160
 None
 0.95A 4lnwA-4r29A:
undetectable		 4lnwA-4r29A:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		12 / 12 ARG A  89
ALA A  92
SER A  98
ARG A 107
GLY A 110
GLN A 111
ALA A 195
MET A 198
GLY A 199
PHE A 202
TYR A 204
TYR A 212
 GOL  A 302 ( 3.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
GOL  A 302 ( 4.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
 0.00A 4r29A-4r29A:
35.3		 4r29A-4r29A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		12 / 12 ARG A  89
ALA A  92
SER A  98
ARG A 107
GLY A 110
GLU A 191
ALA A 195
MET A 198
GLY A 199
PHE A 202
TYR A 204
TYR A 212
 GOL  A 302 ( 3.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
 0.31A 4r29B-4r29A:
31.6		 4r29B-4r29A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		11 / 12 ALA A  92
SER A  98
ARG A 107
GLY A 110
ALA A 195
MET A 198
GLY A 199
PHE A 202
TYR A 204
GLU A 208
TYR A 212
 SAM  A 301 (-3.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.5A)
None
SAM  A 301 (-3.7A)
 0.26A 4r29C-4r29A:
8.1		 4r29C-4r29A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		12 / 12 ALA A  92
SER A  98
ARG A 107
GLY A 110
GLN A 111
ILE A 194
ALA A 195
MET A 198
GLY A 199
PHE A 202
GLU A 208
TYR A 212
 SAM  A 301 (-3.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
GOL  A 302 ( 4.0A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.8A)
None
SAM  A 301 (-3.7A)
 0.25A 4r29D-4r29A:
32.6		 4r29D-4r29A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  87
GLY A  97
ILE A 201
ALA A 161
PRO A 108
 None
 0.85A 5e72A-4r29A:
undetectable		 5e72A-4r29A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 GLU A 200
GLY A 207
PRO A 206
ASP A 210
 None
 1.09A 5kgpA-4r29A:
undetectable		 5kgpA-4r29A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 GLU A 200
GLY A 207
PRO A 206
ASP A 210
 None
 1.09A 5kgpB-4r29A:
undetectable		 5kgpB-4r29A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4r29 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 6 GLY A 199
GLU A 200
PHE A 202
ILE A  87
 SAM  A 301 (-3.6A)
None
SAM  A 301 (-3.8A)
None
 0.74A 5kmfA-4r29A:
undetectable
5kmfC-4r29A:
2.0		 5kmfA-4r29A:
22.15
5kmfC-4r29A:
22.15