SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 9 HIS A 146
TRP A 252
ASP A 355
TRP A 150
GLY A 358
 GLC  A 501 (-4.4A)
GLC  A 501 (-4.0A)
None
None
None
 1.49A 1dwcH-4r2bA:
undetectable		 1dwcH-4r2bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 8 GLN A 182
PHE A 179
GLY A 162
GLY A 163
 None
 0.84A 1ekjE-4r2bA:
undetectable
1ekjF-4r2bA:
undetectable		 1ekjE-4r2bA:
19.06
1ekjF-4r2bA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 9 LEU A 176
LEU A 158
GLU A 171
ILE A 153
VAL A 259
 None
 1.49A 1gx8A-4r2bA:
undetectable		 1gx8A-4r2bA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  42
GLY A  43
ILE A 260
 None
 0.66A 1hxbA-4r2bA:
undetectable		 1hxbA-4r2bA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 4 GLY A  69
ASP A 251
GLY A 191
THR A 198
 None
 0.61A 1hxbB-4r2bA:
undetectable		 1hxbB-4r2bA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 249
GLY A 191
GLY A 190
LEU A 254
ASN A 246
 None
 1.19A 1qzzA-4r2bA:
undetectable		 1qzzA-4r2bA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 ASN A 303
SER A 377
ASP A 201
ARG A 292
THR A 198
 GLC  A 501 (-3.9A)
None
None
None
None
 1.34A 1s14A-4r2bA:
undetectable		 1s14A-4r2bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  42
GLY A  43
ILE A 260
 None
 0.70A 2avsA-4r2bA:
undetectable		 2avsA-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  42
GLY A  43
ILE A 260
 None
 0.64A 2avvA-4r2bA:
undetectable		 2avvA-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  42
GLY A  43
ILE A 260
 None
 0.68A 2avvD-4r2bA:
undetectable		 2avvD-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 11 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.88A 2fxeB-4r2bA:
undetectable		 2fxeB-4r2bA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.90A 2o4sB-4r2bA:
undetectable		 2o4sB-4r2bA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.89A 2r5pB-4r2bA:
undetectable		 2r5pB-4r2bA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 8 SER A 147
ASN A 149
ILE A 300
ASP A 364
 None
 1.05A 2v57A-4r2bA:
2.1		 2v57A-4r2bA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 8 SER A 147
ASN A 149
ILE A 300
ASP A 364
 None
 1.05A 2v57C-4r2bA:
2.1		 2v57C-4r2bA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  42
GLY A  43
ILE A 260
 None
 0.69A 3cyxB-4r2bA:
undetectable		 3cyxB-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A  43
VAL A 259
ILE A 260
 None
 0.90A 3cyxB-4r2bA:
undetectable		 3cyxB-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 11 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.94A 3em4A-4r2bA:
undetectable		 3em4A-4r2bA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 4 ASP A 245
SER A 248
PHE A 247
SER A 241
 None
 1.45A 3i5uA-4r2bA:
undetectable		 3i5uA-4r2bA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 4 GLY A  69
ASP A 251
GLY A 191
THR A 198
 None
 0.63A 3k4vC-4r2bA:
undetectable		 3k4vC-4r2bA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 8 GLY A 225
ILE A 392
PHE A 400
PHE A 233
 None
 0.80A 3ko0B-4r2bA:
0.4
3ko0J-4r2bA:
0.4		 3ko0B-4r2bA:
15.68
3ko0J-4r2bA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 8 GLY A 225
ILE A 392
PHE A 400
PHE A 233
 None
 0.75A 3ko0K-4r2bA:
undetectable
3ko0S-4r2bA:
0.3		 3ko0K-4r2bA:
15.68
3ko0S-4r2bA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 9 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.90A 3oxvA-4r2bA:
undetectable		 3oxvA-4r2bA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 ALA A 379
LEU A  95
GLY A 376
ALA A 368
ASN A 303
 None
GLC  A 501 (-4.8A)
None
None
GLC  A 501 (-3.9A)
 1.19A 3tm4B-4r2bA:
undetectable		 3tm4B-4r2bA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 7 ASN A 384
ALA A 383
VAL A 204
TYR A 212
 None
 1.16A 4ijiH-4r2bA:
undetectable		 4ijiH-4r2bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 PHE A 200
GLY A 402
ASN A 401
SER A 405
PHE A 233
 None
 1.16A 4kowA-4r2bA:
undetectable		 4kowA-4r2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 4 LYS A 360
ASN A 337
ASP A 305
ASP A 364
 None
None
GLC  A 501 (-2.7A)
None
 1.43A 4o1eB-4r2bA:
undetectable		 4o1eB-4r2bA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 11 SER A 377
ASP A 201
ARG A 292
MET A 269
THR A 198
 None
 1.43A 4urnC-4r2bA:
undetectable		 4urnC-4r2bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		3 / 3 GLY A  69
GLY A  70
GLN A 192
 None
GLC  A 501 (-3.3A)
None
 0.44A 5imsA-4r2bA:
undetectable		 5imsA-4r2bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 7 ASN A 144
HIS A 146
TRP A 272
ASN A 303
 None
GLC  A 501 (-4.4A)
GLC  A 501 (-3.5A)
GLC  A 501 (-3.9A)
 1.13A 5x7pA-4r2bA:
undetectable		 5x7pA-4r2bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		5 / 12 GLY A 281
ALA A 280
GLY A 275
VAL A 259
ILE A 260
 None
 0.86A 6difB-4r2bA:
undetectable		 6difB-4r2bA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Ochrobactrum
anthropi) 		4 / 7 TRP A 272
HIS A 380
THR A 198
HIS A  37
 GLC  A 501 (-3.5A)
GLC  A 501 (-3.7A)
None
None
 1.05A 6mn4E-4r2bA:
undetectable		 6mn4E-4r2bA:
19.85