SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.04A 1dfoA-4r2fA:
undetectable		 1dfoA-4r2fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.04A 1dfoB-4r2fA:
undetectable		 1dfoB-4r2fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.04A 1dfoC-4r2fA:
undetectable		 1dfoC-4r2fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.03A 1dfoD-4r2fA:
undetectable		 1dfoD-4r2fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.03A 1eqbA-4r2fA:
undetectable		 1eqbA-4r2fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.02A 1eqbB-4r2fA:
undetectable		 1eqbB-4r2fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.03A 1eqbC-4r2fA:
undetectable		 1eqbC-4r2fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.02A 1eqbD-4r2fA:
undetectable		 1eqbD-4r2fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 ALA A 311
LEU A 175
PRO A 174
THR A 294
ILE A 308
 None
None
None
LB2  A 501 ( 4.6A)
None
 1.31A 1mx8A-4r2fA:
undetectable		 1mx8A-4r2fA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 GLU A 253
ASN A 233
TRP A 193
 None
 1.23A 1r15F-4r2fA:
undetectable		 1r15F-4r2fA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 10 ALA A 199
LEU A 203
GLY A 210
PHE A 211
GLY A 291
 None
 1.45A 1ruaH-4r2fA:
undetectable
1ruaL-4r2fA:
undetectable		 1ruaH-4r2fA:
18.43
1ruaL-4r2fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 7 PHE A 101
TYR A 333
ASN A 335
VAL A 113
 None
 1.36A 1wu8A-4r2fA:
undetectable
1wu8C-4r2fA:
undetectable		 1wu8A-4r2fA:
20.65
1wu8C-4r2fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
LEU A 350
LEU A 353
ILE A 137
VAL A 153
 None
 1.12A 2pnjA-4r2fA:
undetectable		 2pnjA-4r2fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 6 PHE A 124
GLY A 117
GLY A 118
ASN A 329
 None
LB2  A 501 (-3.1A)
LB2  A 501 (-3.3A)
None
 0.97A 2qr2A-4r2fA:
undetectable
2qr2B-4r2fA:
undetectable		 2qr2A-4r2fA:
20.79
2qr2B-4r2fA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 7 LEU A 411
ILE A 227
ALA A 271
ILE A 267
 None
 0.81A 2xkwA-4r2fA:
undetectable		 2xkwA-4r2fA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 THR A 109
SER A 107
PHE A 124
 None
 0.54A 3d4sA-4r2fA:
undetectable		 3d4sA-4r2fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 7 LEU A 324
ILE A 314
MET A 226
ARG A 178
 None
 1.21A 3ik3B-4r2fA:
undetectable		 3ik3B-4r2fA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 9 PHE A 326
GLY A 118
PRO A 327
GLY A 413
ILE A 227
 LB2  A 501 (-4.0A)
LB2  A 501 (-3.3A)
None
None
None
 1.48A 3ko0H-4r2fA:
undetectable
3ko0I-4r2fA:
0.0		 3ko0H-4r2fA:
12.27
3ko0I-4r2fA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 7 ALA A 410
LEU A 408
SER A 405
VAL A 445
 None
 1.06A 3ozkB-4r2fA:
undetectable		 3ozkB-4r2fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 LEU A 140
LEU A 350
LEU A 353
ILE A 137
VAL A 153
 None
 1.24A 4f4dA-4r2fA:
undetectable		 4f4dA-4r2fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 VAL A 166
ALA A 165
TYR A 163
VAL A 164
PHE A 149
 None
 1.27A 4mm4B-4r2fA:
undetectable		 4mm4B-4r2fA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 GLY A 117
THR A 115
ASN A 328
 LB2  A 501 (-3.1A)
None
LB2  A 501 (-3.0A)
 0.71A 5odiG-4r2fA:
undetectable		 5odiG-4r2fA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 TRP A  64
MET A 362
ASN A 363
 None
 1.44A 5uc1B-4r2fA:
undetectable		 5uc1B-4r2fA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 TRP A  64
MET A 362
ASN A 363
 None
 1.45A 5uc1A-4r2fA:
undetectable		 5uc1A-4r2fA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 5 GLY A 316
ASN A 233
ASP A 320
ARG A 250
 None
 1.28A 6dwdB-4r2fA:
undetectable
6dwdD-4r2fA:
undetectable		 6dwdB-4r2fA:
23.61
6dwdD-4r2fA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 5 ARG A 250
GLY A 316
ASN A 233
ASP A 320
 None
 1.32A 6dwjB-4r2fA:
undetectable
6dwjD-4r2fA:
undetectable		 6dwjB-4r2fA:
23.61
6dwjD-4r2fA:
23.61